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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: GRB10

Summary for GRB10

Gene informationGene symbol

GRB10

Ensembl ID

ENSG00000106070

Entrez ID

2887

Gene namegrowth factor receptor bound protein 10
SynonymsNA
Gene typeprotein_coding
UniProtAcc

Q13322


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Dataset with differentially expressed gene: GRB10

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE139386

H3122 cell lineCell lineLung cancerEML4-ALK fusion-positive non-small cell lung cancer (NSCLC)Targeted therapyceritinibNAMalignant cells0.3919910.00e+00

GSE168668

LNCaP cell lineCell lineProstate cancerProstate cancerTargeted therapyenzalutamideNAMalignant cells0.2894180.00e+00

GSE131984_JQ1Pac

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapyJQ1 + paclitaxelNAMalignant cells-0.3381941.97e-12

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Expression of GRB10 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to GRB10

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GRB10

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
GRB10hsa-miR-447899.0672NM_001001549
GRB10hsa-miR-392998.3228NM_001001549
GRB10hsa-miR-4742-3p97.695NM_001001555
GRB10hsa-miR-4685-5p96.0237NM_001001549
GRB10hsa-miR-6837-5p96.0237NM_001001549
GRB10hsa-miR-222-3p94.5854NM_001001549
GRB10hsa-miR-221-3p94.5854NM_001001549
GRB10hsa-miR-670-5p93.5077NM_001001549
GRB10hsa-miR-345-3p93.3166NM_001001549
GRB10hsa-miR-504-3p93.0535NM_001001549
GRB10hsa-miR-33a-3p92.434NM_001001549
GRB10hsa-miR-570-3p91.3634NM_001001549
GRB10hsa-miR-431990.0264NM_001001549
GRB10hsa-miR-432888.5636NM_001001555
GRB10hsa-miR-519a-3p88.327NM_001001549
GRB10hsa-miR-519b-3p88.327NM_001001549
GRB10hsa-miR-519c-3p88.327NM_001001549
GRB10hsa-miR-125a-5p87.9002NM_001001549
GRB10hsa-miR-5195-3p87.3257NM_001001549
GRB10hsa-miR-145-5p87.3257NM_001001549
GRB10hsa-let-7a-2-3p86.6691NM_001001549
GRB10hsa-let-7g-3p86.6691NM_001001549
GRB10hsa-miR-1213586.2748NM_001001555
GRB10hsa-miR-181b-5p86.2736NM_001001549
GRB10hsa-miR-181d-5p86.2736NM_001001549
GRB10hsa-miR-181c-5p86.2736NM_001001549
GRB10hsa-miR-426286.2736NM_001001549
GRB10hsa-miR-181a-5p86.2736NM_001001549
GRB10hsa-miR-1213686.0168NM_001001549
GRB10hsa-miR-319685.2163NM_001001555
GRB10hsa-miR-125b-5p85.0431NM_001001549
GRB10hsa-miR-29884.6614NM_001001549
GRB10hsa-miR-20a-3p84.484NM_001001549
GRB10hsa-miR-3613-3p83.4235NM_001001549
GRB10hsa-miR-5589-3p82.6606NM_001001549
GRB10hsa-miR-30a-5p82.4154NM_001001549
GRB10hsa-miR-30d-5p82.4154NM_001001549
GRB10hsa-miR-30b-5p82.4154NM_001001549
GRB10hsa-miR-30e-5p82.4154NM_001001549
GRB10hsa-miR-30c-5p82.4154NM_001001549
GRB10hsa-miR-576-5p82.0332NM_001001555
GRB10hsa-let-7c-3p82.0061NM_001001555
GRB10hsa-miR-129781.9175NM_001001549
GRB10hsa-miR-469281.0933NM_001001549
GRB10hsa-miR-451481.0933NM_001001549
GRB10hsa-miR-318080.944NM_001001555
GRB10hsa-miR-6816-5p80.944NM_001001555
GRB10hsa-miR-3180-3p80.944NM_001001555
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Motifs and transcription factors (TFs) regulating GRB10

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
GRB10taipale_tf_pairs__ATF4_CEBPD_NGATGATGCAATNN_CAPATF4; CEBPD (directAnnotation).
GRB10metacluster_174.3MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
GRB10metacluster_98.1ZNF524 (directAnnotation).
GRB10taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2ELK1; GCM1 (directAnnotation).
GRB10metacluster_166.2ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
GRB10taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HTELK1; HOXA1 (directAnnotation).
GRB10swissregulon__hs__ELF2ELF2 (directAnnotation).
GRB10taipale_tf_pairs__ELF2_NATGCGGAAGTR_HTELF2 (directAnnotation).
GRB10taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAPELK1; EOMES (directAnnotation).
GRB10taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_reprELK1; TBX21 (directAnnotation).
GRB10jaspar__MA1708.1ETV7 (directAnnotation).
GRB10taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAPELK1; FOXO1 (directAnnotation).
GRB10metacluster_183.4ETS1 (inferredBy_Orthology).
GRB10taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_reprERF; FOXI1 (directAnnotation).
GRB10transfac_pro__M04950EGR1 (directAnnotation).
GRB10taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_reprETV2; HES7 (directAnnotation).
GRB10taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAPETV4; GCM1 (directAnnotation).
GRB10transfac_pro__M05427ZNF516 (directAnnotation).
GRB10metacluster_172.6CHD2; E2F1 (directAnnotation).
GRB10transfac_pro__M06071ZNF814 (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."