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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: GPT2

Summary for GPT2

Gene information	Gene symbol	GPT2
	Ensembl ID	ENSG00000166123
	Entrez ID	84706
	Gene name	glutamic--pyruvic transaminase 2
	Synonyms	ALT2
	Gene type	protein_coding
	UniProtAcc	Q8TD30

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Dataset with differentially expressed gene: GPT2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.284751	1.11e-24

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Expression of GPT2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GPT2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GPT2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GPT2	hsa-miR-5582-5p	96.3356	NM_001142466
GPT2	hsa-miR-3163	94.586	NM_001142466
GPT2	hsa-miR-124-3p	93.7113	NM_001142466
GPT2	hsa-miR-506-3p	93.7113	NM_001142466
GPT2	hsa-miR-520d-5p	93.1494	NM_001142466
GPT2	hsa-miR-524-5p	93.1494	NM_001142466
GPT2	hsa-miR-3117-3p	90.2198	NM_001142466
GPT2	hsa-miR-7850-5p	87.2679	NM_001142466
GPT2	hsa-miR-30e-5p	86.6044	NM_001142466
GPT2	hsa-miR-30b-5p	86.6044	NM_001142466
GPT2	hsa-miR-30c-5p	86.6044	NM_001142466
GPT2	hsa-miR-30d-5p	86.6044	NM_001142466
GPT2	hsa-miR-30a-5p	86.6044	NM_001142466
GPT2	hsa-miR-519e-5p	86.0818	NM_001142466
GPT2	hsa-miR-515-5p	86.0818	NM_001142466
GPT2	hsa-miR-6720-5p	85.9914	NM_001142466
GPT2	hsa-miR-6512-3p	85.9914	NM_001142466
GPT2	hsa-miR-513a-5p	85.8915	NM_001142466
GPT2	hsa-miR-9985	85.224	NM_001142466
GPT2	hsa-miR-27b-3p	85.224	NM_001142466
GPT2	hsa-miR-27a-3p	85.224	NM_001142466
GPT2	hsa-miR-561-3p	85.0059	NM_001142466
GPT2	hsa-miR-4520-2-3p	82.9665	NM_001142466
GPT2	hsa-miR-7106-5p	82.8509	NM_001142466
GPT2	hsa-miR-4759	82.3805	NM_001142466
GPT2	hsa-miR-6780a-5p	82.0614	NM_001142466
GPT2	hsa-miR-181b-2-3p	81.95	NM_001142466
GPT2	hsa-miR-181b-3p	81.95	NM_001142466
GPT2	hsa-miR-6771-3p	81.5325	NM_001142466
GPT2	hsa-miR-4477b	81.3137	NM_001142466
GPT2	hsa-miR-6513-3p	80.3348	NM_001142466

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Motifs and transcription factors (TFs) regulating GPT2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GPT2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
GPT2	"Alanine"	DB00160	small molecule
GPT2	"Glutamic acid"	DB00142	small molecule
GPT2	"Phenelzine"	DB00780	small molecule
GPT2	"Pyridoxal phosphate"	DB00114	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."