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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: GPR82

Summary for GPR82

Gene information	Gene symbol	GPR82
	Ensembl ID	ENSG00000171657
	Entrez ID	27197
	Gene name	G protein-coupled receptor 82
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q96P67

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Dataset with differentially expressed gene: GPR82

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	B cells	-0.789235	1.19e-15

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Expression of GPR82 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GPR82

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GPR82

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GPR82	hsa-miR-5011-5p	99.9986	NM_080817
GPR82	hsa-miR-190a-3p	99.9396	NM_080817
GPR82	hsa-miR-5692a	97.6352	NM_080817
GPR82	hsa-miR-12123	97.1116	NM_080817
GPR82	hsa-miR-4422	95.2479	NM_080817
GPR82	hsa-miR-3143	91.758	NM_080817
GPR82	hsa-miR-6778-3p	90.9647	NM_080817
GPR82	hsa-miR-6504-3p	89.2479	NM_080817
GPR82	hsa-miR-545-5p	88.0206	NM_080817
GPR82	hsa-miR-103a-2-5p	86.9547	NM_080817
GPR82	hsa-miR-103a-1-5p	86.9547	NM_080817
GPR82	hsa-miR-7151-3p	86.7825	NM_080817
GPR82	hsa-miR-10399-5p	86.6643	NM_080817
GPR82	hsa-miR-569	86.1855	NM_080817
GPR82	hsa-miR-888-3p	85.3755	NM_080817
GPR82	hsa-miR-548t-3p	83.1409	NM_080817
GPR82	hsa-miR-548ap-3p	83.1409	NM_080817
GPR82	hsa-miR-548aa	83.1409	NM_080817
GPR82	hsa-miR-1277-5p	82.8193	NM_080817
GPR82	hsa-miR-6509-5p	82.6803	NM_080817
GPR82	hsa-miR-6819-5p	82.6215	NM_080817
GPR82	hsa-miR-6737-5p	82.6215	NM_080817
GPR82	hsa-miR-7153-3p	81.8943	NM_080817

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Motifs and transcription factors (TFs) regulating GPR82

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GPR82	metacluster_113.4	MYB; MYB; MYBL1; MYBL2 (directAnnotation). MYB; MYB; MYBL1; MYBL2 (inferredBy_Orthology).
GPR82	transfac_pro__M05803	ZNF584 (directAnnotation).
GPR82	metacluster_141.2	E2F2; E2F3 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."