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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: GPR34

Summary for GPR34

Gene information	Gene symbol	GPR34
	Ensembl ID	ENSG00000171659
	Entrez ID	2857
	Gene name	G protein-coupled receptor 34
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q9UPC5

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Dataset with differentially expressed gene: GPR34

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Mono/Macro	-0.281055	1.35e-08
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	0.504734	3.40e-30

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Expression of GPR34 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GPR34

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GPR34

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GPR34	hsa-miR-3646	98.8888	NM_001097579
GPR34	hsa-miR-5579-3p	96.9965	NM_001097579
GPR34	hsa-miR-381-3p	96.6735	NM_001097579
GPR34	hsa-miR-300	96.6735	NM_001097579
GPR34	hsa-miR-4719	93.4215	NM_001097579
GPR34	hsa-miR-299-5p	93.0406	NM_001097579
GPR34	hsa-miR-452-3p	92.2941	NM_001097579
GPR34	hsa-miR-153-5p	89.8557	NM_001097579
GPR34	hsa-miR-3662	89.1298	NM_001097579
GPR34	hsa-miR-3976	89.0103	NM_001097579
GPR34	hsa-miR-6730-3p	87.1345	NM_001097579
GPR34	hsa-miR-4760-3p	86.6128	NM_001097579
GPR34	hsa-miR-606	86.6043	NM_001097579
GPR34	hsa-miR-1250-3p	85.3667	NM_001097579
GPR34	hsa-miR-664a-3p	85.3238	NM_001097579
GPR34	hsa-miR-4682	84.3969	NM_001097579
GPR34	hsa-miR-5693	83.9887	NM_001097579
GPR34	hsa-miR-4503	83.4883	NM_001097579
GPR34	hsa-miR-664b-3p	82.9217	NM_001097579
GPR34	hsa-miR-579-3p	82.9217	NM_001097579
GPR34	hsa-miR-5696	82.5333	NM_001097579
GPR34	hsa-miR-22-5p	81.5889	NM_001097579
GPR34	hsa-miR-183-5p	81.5627	NM_001097579
GPR34	hsa-miR-3688-5p	81.0483	NM_001097579
GPR34	hsa-miR-1290	80.0442	NM_001097579

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Motifs and transcription factors (TFs) regulating GPR34

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GPR34	metacluster_22.12	NFE2; NFE2L1 (directAnnotation).
GPR34	transfac_pro__M05387	ZNF653 (inferredBy_Orthology).
GPR34	kznf__ZNF25_Imbeault2017_RP_ChIP-seq	ZNF25 (directAnnotation).
GPR34	tfdimers__MD00158	DBP; ZNF354C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."