Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: GPR137B

Summary for GPR137B

Gene information	Gene symbol	GPR137B
	Ensembl ID	ENSG00000077585
	Entrez ID	7107
	Gene name	G protein-coupled receptor 137B
	Synonyms	TM7SF1
	Gene type	protein_coding
	UniProtAcc	NA

Top

Dataset with differentially expressed gene: GPR137B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.57484	2.09e-03
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.867185	0.00e+00

Top

Expression of GPR137B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to GPR137B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating GPR137B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GPR137B	hsa-miR-1278	95.9159	NM_003272
GPR137B	hsa-miR-3609	94.589	NM_003272
GPR137B	hsa-miR-548ah-5p	94.589	NM_003272
GPR137B	hsa-miR-106b-5p	94.1128	NM_003272
GPR137B	hsa-miR-20a-5p	94.1128	NM_003272
GPR137B	hsa-miR-106a-5p	92.8389	NM_003272
GPR137B	hsa-miR-20b-5p	92.8389	NM_003272
GPR137B	hsa-miR-519d-3p	92.8389	NM_003272
GPR137B	hsa-miR-526b-3p	92.8389	NM_003272
GPR137B	hsa-miR-17-5p	92.8389	NM_003272
GPR137B	hsa-miR-93-5p	92.8389	NM_003272
GPR137B	hsa-miR-548n	91.9618	NM_003272
GPR137B	hsa-miR-5690	91.8514	NM_003272
GPR137B	hsa-miR-6502-3p	90.9015	NM_003272
GPR137B	hsa-miR-137-3p	90.5839	NM_003272
GPR137B	hsa-miR-371b-3p	90.424	NM_003272
GPR137B	hsa-miR-138-2-3p	89.735	NM_003272
GPR137B	hsa-miR-19a-3p	89.4585	NM_003272
GPR137B	hsa-miR-19b-3p	89.4585	NM_003272
GPR137B	hsa-miR-514b-5p	88.8504	NM_003272
GPR137B	hsa-miR-513c-5p	88.8504	NM_003272
GPR137B	hsa-miR-4796-3p	88.7972	NM_003272
GPR137B	hsa-miR-7-2-3p	85.8304	NM_003272
GPR137B	hsa-miR-7-1-3p	85.8304	NM_003272
GPR137B	hsa-miR-548ar-3p	85.2061	NM_003272
GPR137B	hsa-miR-4795-3p	83.5183	NM_003272
GPR137B	hsa-miR-12136	82.9545	NM_003272
GPR137B	hsa-miR-18b-3p	81.1152	NM_003272
GPR137B	hsa-miR-548az-3p	80.916	NM_003272
GPR137B	hsa-miR-548bc	80.916	NM_003272
GPR137B	hsa-miR-548e-3p	80.916	NM_003272
GPR137B	hsa-miR-548a-3p	80.916	NM_003272
GPR137B	hsa-miR-548f-3p	80.916	NM_003272
GPR137B	hsa-miR-6845-5p	80.8698	NM_003272
GPR137B	hsa-miR-6762-5p	80.8698	NM_003272

Page: 1

Top

Motifs and transcription factors (TFs) regulating GPR137B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GPR137B	metacluster_7.13	ZFX (directAnnotation).
GPR137B	metacluster_151.2	ZNF23 (directAnnotation).
GPR137B	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
GPR137B	transfac_pro__M05479	ZNF580 (directAnnotation).
GPR137B	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
GPR137B	jaspar__MA0079.5	SP1 (directAnnotation).
GPR137B	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
GPR137B	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
GPR137B	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
GPR137B	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
GPR137B	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
GPR137B	transfac_pro__M07387	ZBTB7A (directAnnotation).
GPR137B	transfac_pro__M07436	WT1 (directAnnotation).
GPR137B	transfac_pro__M00716	ZBTB14 (directAnnotation).
GPR137B	swissregulon__hs__CHD1	CHD1 (directAnnotation).
GPR137B	transfac_pro__M03876	ZBTB33 (directAnnotation).
GPR137B	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
GPR137B	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
GPR137B	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
GPR137B	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."