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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: GPNMB

Summary for GPNMB

Gene information	Gene symbol	GPNMB
	Ensembl ID	ENSG00000136235
	Entrez ID	10457
	Gene name	glycoprotein nmb
	Synonyms	HGFIN\|NMB
	Gene type	protein_coding
	UniProtAcc	Q14956

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Dataset with differentially expressed gene: GPNMB

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.251638	5.40e-26
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Mono/Macro	0.679177	2.53e-10
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.939885	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mono/Macro	0.435405	1.28e-03
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	-0.809307	2.37e-03
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.681194	1.06e-04
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-1.60968	0.00e+00

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Expression of GPNMB in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GPNMB

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GPNMB

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GPNMB	hsa-miR-3646	90.7644	NM_002510
GPNMB	hsa-miR-520f-5p	90.386	NM_001005340
GPNMB	hsa-miR-4306	87.9167	NM_002510
GPNMB	hsa-miR-607	86.4918	NM_001005340
GPNMB	hsa-miR-3148	86.1023	NM_002510
GPNMB	hsa-miR-494-3p	85.5343	NM_002510
GPNMB	hsa-miR-4803	84.5819	NM_002510
GPNMB	hsa-miR-185-5p	83.9027	NM_002510
GPNMB	hsa-miR-4644	83.9027	NM_002510
GPNMB	hsa-miR-4659b-5p	80.8225	NM_002510

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Motifs and transcription factors (TFs) regulating GPNMB

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GPNMB	hocomoco__ZN652_HUMAN.H11MO.0.D	ZNF652 (directAnnotation).
GPNMB	taipale_tf_pairs__TEAD4_SPIB_RGAATGCGGAAGTN_CAP_1	SPIB; TEAD4 (directAnnotation).
GPNMB	tfdimers__MD00438	E2F1; NKX3-2 (directAnnotation).
GPNMB	cisbp__M04023	CREB1 (directAnnotation).
GPNMB	hdpi__NFATC3	NFATC3 (directAnnotation).
GPNMB	transfac_pro__M04699	MAFK (directAnnotation).
GPNMB	metacluster_190.8	ILF2; NFAT5; NFAT5; NFAT5; NFAT5; NFATC1; NFATC2; NFATC3; NFATC4; NFATC4 (directAnnotation).
GPNMB	transfac_pro__M06845	ZBTB38 (directAnnotation).
GPNMB	metacluster_22.13	MAFK (inferredBy_Orthology).
GPNMB	kznf__ZNF547_Imbeault2017_OM_MEME	ZNF547 (directAnnotation).
GPNMB	kznf__ZNF792_Imbeault2017_RP_ChIP-seq	ZNF792 (directAnnotation).
GPNMB	tfdimers__MD00095	ELF1; NEUROD1 (directAnnotation).
GPNMB	jaspar__MA1939.1	SREBF2 (directAnnotation).
GPNMB	cisbp__M01815	CEBPE (inferredBy_Orthology).
GPNMB	hdpi__TFAM	TFAM (directAnnotation).
GPNMB	metacluster_172.22	E4F1 (inferredBy_Orthology).
GPNMB	hdpi__MYEF2	MYEF2 (directAnnotation).
GPNMB	transfac_pro__M04913	ZBTB7A (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
GPNMB	"Glembatumumab vedotin"	DB05996	biotech

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."