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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: GPM6A

Summary for GPM6A

Gene information	Gene symbol	GPM6A
	Ensembl ID	ENSG00000150625
	Entrez ID	2823
	Gene name	glycoprotein M6A
	Synonyms	GPM6
	Gene type	protein_coding
	UniProtAcc	P51674

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Dataset with differentially expressed gene: GPM6A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Plasma cells	0.350454	3.22e-02

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Expression of GPM6A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GPM6A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GPM6A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GPM6A	hsa-miR-1323	99.6806	NM_001261447
GPM6A	hsa-miR-8084	99.6795	NM_001261447
GPM6A	hsa-miR-548o-3p	99.6156	NM_001261447
GPM6A	hsa-let-7c-3p	99.5512	NM_001261447
GPM6A	hsa-miR-200b-3p	99.3538	NM_001261447
GPM6A	hsa-miR-429	99.3538	NM_001261447
GPM6A	hsa-miR-200c-3p	99.3538	NM_001261447
GPM6A	hsa-miR-607	98.8386	NM_001261447
GPM6A	hsa-miR-3646	98.7693	NM_001261447
GPM6A	hsa-miR-1252-3p	98.7522	NM_001261447
GPM6A	hsa-miR-12136	98.5665	NM_001261447
GPM6A	hsa-miR-548av-5p	97.969	NM_001261447
GPM6A	hsa-miR-8054	97.969	NM_001261447
GPM6A	hsa-miR-548k	97.969	NM_001261447
GPM6A	hsa-miR-432-3p	97.8697	NM_001261447
GPM6A	hsa-miR-3074-3p	97.8287	NM_001261447
GPM6A	hsa-miR-548m	96.8354	NM_001261447
GPM6A	hsa-miR-4803	96.5276	NM_001261447
GPM6A	hsa-miR-217-5p	96.4305	NM_001261447
GPM6A	hsa-miR-4719	96.4274	NM_001261447
GPM6A	hsa-miR-6807-3p	96.3674	NM_001261447
GPM6A	hsa-miR-6851-3p	95.7313	NM_001261447
GPM6A	hsa-miR-133b	95.6339	NM_001261447
GPM6A	hsa-miR-133a-3p	95.6339	NM_001261447
GPM6A	hsa-miR-6757-3p	95.5952	NM_001261447
GPM6A	hsa-miR-5680	95.425	NM_001261447
GPM6A	hsa-miR-4801	94.9093	NM_001261447
GPM6A	hsa-miR-586	94.702	NM_001261447
GPM6A	hsa-miR-495-3p	94.6359	NM_001261447
GPM6A	hsa-miR-551b-5p	94.6021	NM_001261447
GPM6A	hsa-miR-548l	94.5326	NM_001261447
GPM6A	hsa-miR-5688	94.4676	NM_001261447
GPM6A	hsa-miR-21-3p	94.3686	NM_001261447
GPM6A	hsa-miR-122b-3p	94.3686	NM_001261447
GPM6A	hsa-miR-509-3-5p	94.079	NM_001261447
GPM6A	hsa-miR-509-5p	94.079	NM_001261447
GPM6A	hsa-miR-1178-3p	93.9855	NM_001261447
GPM6A	hsa-miR-520d-5p	93.8613	NM_001261447
GPM6A	hsa-miR-524-5p	93.8613	NM_001261447
GPM6A	hsa-miR-570-3p	93.7327	NM_001261447
GPM6A	hsa-miR-1179	93.6916	NM_001261447
GPM6A	hsa-miR-4418	93.5028	NM_001261447
GPM6A	hsa-miR-4731-3p	92.4965	NM_001261447
GPM6A	hsa-miR-2115-3p	92.0546	NM_001261447
GPM6A	hsa-miR-500a-3p	91.8003	NM_001261447
GPM6A	hsa-miR-1277-5p	91.2342	NM_001261447
GPM6A	hsa-miR-4328	90.89	NM_001261447
GPM6A	hsa-miR-218-5p	90.2735	NM_001261447
GPM6A	hsa-miR-148b-3p	90.2498	NM_001261447
GPM6A	hsa-miR-152-3p	90.2498	NM_001261447

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Motifs and transcription factors (TFs) regulating GPM6A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GPM6A	tfdimers__MD00018	ELF1; ELF2; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV4; ETV6; ETV7; FLI1; GABPA; GABPB1; SPI1; SPIB; TAF6; TBP (directAnnotation).
GPM6A	transfac_pro__M05939	ZNF471 (directAnnotation).
GPM6A	transfac_public__M00039	CREB1 (directAnnotation).
GPM6A	hocomoco__SOX9_HUMAN.H11MO.1.B	SOX9 (directAnnotation).
GPM6A	metacluster_179.5	MEF2A; MEF2A; MEF2A; MEF2A (directAnnotation).
GPM6A	transfac_pro__M05447	INSM2 (inferredBy_Orthology).
GPM6A	tfdimers__MD00177	STAT1; TCF7L1 (directAnnotation).
GPM6A	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
GPM6A	tfdimers__MD00550	PITX3; TEAD1 (directAnnotation).
GPM6A	metacluster_4.4	NANOG; NANOG; SOX2; SOX2; SOX2; SOX3; SOX4; SOX4 (directAnnotation). NANOGP8; SOX2 (inferredBy_Orthology).
GPM6A	transfac_pro__M06081	ZNF99 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."