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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: GPAT3

Summary for GPAT3

Gene information	Gene symbol	GPAT3
	Ensembl ID	ENSG00000138678
	Entrez ID	84803
	Gene name	glycerol-3-phosphate acyltransferase 3
	Synonyms	AGPAT10\|AGPAT9\|HMFN0839\|LPAAT-theta\|MAG1\|MGC11324
	Gene type	protein_coding
	UniProtAcc	Q53EU6

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Dataset with differentially expressed gene: GPAT3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.464759	0.00e+00

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Expression of GPAT3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GPAT3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GPAT3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GPAT3	hsa-miR-4489	89.3695	NM_032717
GPAT3	hsa-miR-4799-3p	88.6441	NM_032717
GPAT3	hsa-miR-4720-5p	88.6441	NM_032717
GPAT3	hsa-miR-5588-5p	88.6441	NM_032717
GPAT3	hsa-miR-6511a-3p	85.5996	NM_032717
GPAT3	hsa-miR-6511b-3p	85.5996	NM_032717
GPAT3	hsa-miR-409-5p	83.3444	NM_032717
GPAT3	hsa-miR-6074	83.2488	NM_032717
GPAT3	hsa-miR-3117-5p	81.8199	NM_032717
GPAT3	hsa-miR-3529-3p	81.0794	NM_032717
GPAT3	hsa-miR-5001-3p	80.144	NM_001256421

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Motifs and transcription factors (TFs) regulating GPAT3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GPAT3	metacluster_160.20	JUND; PRDM15 (directAnnotation).
GPAT3	cisbp__M00341	PAX6 (directAnnotation).
GPAT3	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
GPAT3	transfac_pro__M01199	TRIM28 (directAnnotation).
GPAT3	transfac_pro__M03806	ZBTB7C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."