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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: GOSR2

Summary for GOSR2

Gene information	Gene symbol	GOSR2
	Ensembl ID	ENSG00000108433
	Entrez ID	9570
	Gene name	golgi SNAP receptor complex member 2
	Synonyms	Bos1\|GS27
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: GOSR2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	-0.5044	3.36e-34
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	-0.477187	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.336829	2.08e-18
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.380876	1.53e-14
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.318849	7.91e-12
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.296377	1.14e-07

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Expression of GOSR2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GOSR2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GOSR2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GOSR2	hsa-miR-12122	96.536	NM_001321134
GOSR2	hsa-miR-3671	96.0466	NM_001321133
GOSR2	hsa-miR-4799-5p	95.1071	NM_054022
GOSR2	hsa-miR-3919	92.8051	NM_001012511
GOSR2	hsa-miR-5006-3p	92.3908	NM_001321133
GOSR2	hsa-miR-4755-5p	92.3908	NM_001321133
GOSR2	hsa-miR-616-5p	91.4218	NM_054022
GOSR2	hsa-miR-371b-5p	91.4218	NM_054022
GOSR2	hsa-miR-373-5p	91.4218	NM_054022
GOSR2	hsa-miR-2115-5p	90.9306	NM_001321134
GOSR2	hsa-miR-7154-5p	90.4923	NM_001321133
GOSR2	hsa-miR-2467-3p	90.213	NM_001012511
GOSR2	hsa-miR-10527-5p	89.6967	NM_001321133
GOSR2	hsa-miR-197-3p	88.5604	NM_001321134
GOSR2	hsa-miR-6735-5p	88.0433	NM_001012511
GOSR2	hsa-miR-7843-5p	88.0433	NM_001012511
GOSR2	hsa-miR-4632-5p	88.0433	NM_001012511
GOSR2	hsa-miR-6879-5p	88.0433	NM_001012511
GOSR2	hsa-miR-4436b-3p	88.0433	NM_001012511
GOSR2	hsa-miR-4735-3p	87.7341	NM_001321133
GOSR2	hsa-miR-603	87.2738	NM_001321134
GOSR2	hsa-miR-380-3p	86.4902	NM_054022
GOSR2	hsa-miR-4302	86.357	NM_001012511
GOSR2	hsa-miR-4691-3p	85.5019	NM_001012511
GOSR2	hsa-miR-513c-3p	85.0461	NM_001012511
GOSR2	hsa-miR-513a-3p	85.0461	NM_001012511
GOSR2	hsa-miR-18b-5p	85.0091	NM_001321133
GOSR2	hsa-miR-18a-5p	85.0091	NM_001321133
GOSR2	hsa-miR-4317	84.8279	NM_001012511
GOSR2	hsa-miR-8485	84.811	NM_001321134
GOSR2	hsa-miR-3202	84.6736	NM_001321134
GOSR2	hsa-miR-5006-5p	84.5815	NM_001321133
GOSR2	hsa-miR-6768-3p	83.6015	NM_001321134
GOSR2	hsa-miR-494-3p	83.5556	NM_054022
GOSR2	hsa-miR-3606-3p	81.6272	NM_001012511
GOSR2	hsa-miR-6778-3p	80.3523	NM_054022
GOSR2	hsa-miR-570-3p	80.0343	NM_001321134

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Motifs and transcription factors (TFs) regulating GOSR2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GOSR2	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
GOSR2	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
GOSR2	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
GOSR2	swissregulon__hs__ELF2	ELF2 (directAnnotation).
GOSR2	jaspar__MA1483.2	ELF2 (directAnnotation).
GOSR2	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
GOSR2	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
GOSR2	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
GOSR2	jaspar__MA1708.1	ETV7 (directAnnotation).
GOSR2	swissregulon__hs__ETV6	ETV6 (directAnnotation).
GOSR2	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
GOSR2	taipale_tf_pairs__FLI1_FOXI1_RCCGGATGTTKWY_CAP	FLI1; FOXI1 (directAnnotation).
GOSR2	taipale_tf_pairs__ETV2_SPDEF_NSCGGACGGAWATCCGSNT_CAP	ETV2; SPDEF (directAnnotation).
GOSR2	taipale_tf_pairs__ERF_DLX3_RSCGGAANNNNYAATTA_CAP_repr	DLX3; ERF (directAnnotation).
GOSR2	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
GOSR2	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
GOSR2	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
GOSR2	metacluster_161.31	PRRX2 (directAnnotation).
GOSR2	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
GOSR2	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
GOSR2	transfac_pro__M04748	GABPA (directAnnotation).
GOSR2	transfac_pro__M01660	GABPA (directAnnotation).
GOSR2	transfac_pro__M05956	BCL11B (directAnnotation).
GOSR2	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
GOSR2	transfac_pro__M06388	ZNF677 (directAnnotation).
GOSR2	tfdimers__MD00302	IRF7; IRF8 (directAnnotation).
GOSR2	taipale_cyt_meth__CDX2_NRTCGTAAANNN_eDBD_meth	CDX2 (directAnnotation).
GOSR2	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
GOSR2	hdpi__ETV4	ETV4 (directAnnotation).
GOSR2	hdpi__TP73	TP73 (directAnnotation).
GOSR2	cisbp__M02645	ETS1 (directAnnotation).
GOSR2	cisbp__M08198	ELF1 (directAnnotation).
GOSR2	hdpi__ELF2	ELF2 (directAnnotation).
GOSR2	swissregulon__hs__ELK1	ELK1 (directAnnotation).
GOSR2	metacluster_183.4	ETS1 (inferredBy_Orthology).
GOSR2	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
GOSR2	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
GOSR2	jaspar__MA1932.1	HOXB13 (directAnnotation).
GOSR2	jaspar__MA1933.1	SREBF2 (directAnnotation).
GOSR2	taipale_tf_pairs__ETV5_HOXB13_NNCGGANGNNNTWAA_CAP	ETV5; HOXB13 (directAnnotation).
GOSR2	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
GOSR2	transfac_pro__M00492	STAT1 (directAnnotation).
GOSR2	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
GOSR2	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
GOSR2	taipale_tf_pairs__ETV5_HOXA13_NNCGGAWGTNRTWAA_CAP	ETV5; HOXA13 (directAnnotation).
GOSR2	cisbp__M00808	MYPOP (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."