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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: GOLT1B

Summary for GOLT1B

Gene information	Gene symbol	GOLT1B
	Ensembl ID	ENSG00000111711
	Entrez ID	51026
	Gene name	golgi transport 1B
	Synonyms	CGI-141\|GOT1\|YMR292W
	Gene type	protein_coding
	UniProtAcc	Q9Y3E0

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Dataset with differentially expressed gene: GOLT1B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.26816	2.18e-14
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.299328	6.06e-36
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.256381	1.52e-06
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.349474	1.59e-37

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Expression of GOLT1B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GOLT1B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GOLT1B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GOLT1B	hsa-miR-3614-3p	96.5408	NM_016072
GOLT1B	hsa-miR-5692a	95.8799	NM_016072
GOLT1B	hsa-miR-4652-3p	95.5468	NM_016072
GOLT1B	hsa-miR-5000-5p	94.922	NM_016072
GOLT1B	hsa-miR-7853-5p	93.8136	NM_016072
GOLT1B	hsa-miR-105-5p	93.8136	NM_016072
GOLT1B	hsa-miR-6516-3p	93.5329	NM_016072
GOLT1B	hsa-miR-5093	92.9254	NM_016072
GOLT1B	hsa-miR-3133	91.8057	NM_016072
GOLT1B	hsa-miR-10395-3p	91.8022	NM_016072
GOLT1B	hsa-miR-4743-3p	91.0848	NM_016072
GOLT1B	hsa-miR-186-5p	91.0064	NM_016072
GOLT1B	hsa-miR-3978	89.9298	NM_016072
GOLT1B	hsa-miR-4427	89.6181	NM_016072
GOLT1B	hsa-miR-4699-3p	89.0908	NM_016072
GOLT1B	hsa-miR-3618	88.4446	NM_016072
GOLT1B	hsa-miR-2113	88.09	NM_016072
GOLT1B	hsa-miR-129-1-3p	86.2422	NM_016072
GOLT1B	hsa-miR-129-2-3p	86.2422	NM_016072
GOLT1B	hsa-miR-4500	85.7957	NM_016072
GOLT1B	hsa-miR-7159-5p	84.1636	NM_016072
GOLT1B	hsa-miR-548c-3p	84.0842	NM_016072
GOLT1B	hsa-miR-6759-3p	83.6777	NM_016072
GOLT1B	hsa-miR-6832-3p	83.0855	NM_016072
GOLT1B	hsa-miR-552-5p	83.0783	NM_016072
GOLT1B	hsa-miR-4775	82.9234	NM_016072
GOLT1B	hsa-let-7a-5p	82.7058	NM_016072
GOLT1B	hsa-miR-98-5p	82.7058	NM_016072
GOLT1B	hsa-let-7f-5p	82.7058	NM_016072
GOLT1B	hsa-let-7g-5p	82.7058	NM_016072
GOLT1B	hsa-let-7b-5p	82.7058	NM_016072
GOLT1B	hsa-let-7c-5p	82.7058	NM_016072
GOLT1B	hsa-let-7i-5p	82.7058	NM_016072
GOLT1B	hsa-let-7e-5p	82.7058	NM_016072
GOLT1B	hsa-miR-1265	82.4359	NM_016072
GOLT1B	hsa-miR-582-5p	82.1365	NM_016072
GOLT1B	hsa-miR-676-5p	81.8862	NM_016072
GOLT1B	hsa-miR-3140-3p	81.4656	NM_016072
GOLT1B	hsa-miR-548av-5p	80.9891	NM_016072
GOLT1B	hsa-miR-8054	80.9891	NM_016072
GOLT1B	hsa-miR-548k	80.9891	NM_016072
GOLT1B	hsa-miR-3121-5p	80.0086	NM_016072

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Motifs and transcription factors (TFs) regulating GOLT1B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GOLT1B	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
GOLT1B	metacluster_7.8	ZBTB7A; ZNF28 (directAnnotation).
GOLT1B	metacluster_135.11	NR2C2 (directAnnotation).
GOLT1B	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
GOLT1B	metacluster_175.1	ZNF283 (directAnnotation).
GOLT1B	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
GOLT1B	transfac_pro__M03806	ZBTB7C (directAnnotation).
GOLT1B	transfac_pro__M01298	MECP2 (directAnnotation).
GOLT1B	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
GOLT1B	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."