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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: GOLPH3L

Summary for GOLPH3L

Gene information	Gene symbol	GOLPH3L
	Ensembl ID	ENSG00000143457
	Entrez ID	55204
	Gene name	golgi phosphoprotein 3 like
	Synonyms	GPP34R
	Gene type	protein_coding
	UniProtAcc	Q9H4A5

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Dataset with differentially expressed gene: GOLPH3L

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.597845	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.298502	0.00e+00

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Expression of GOLPH3L in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GOLPH3L

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GOLPH3L

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GOLPH3L	hsa-miR-570-3p	96.5242	NM_018178
GOLPH3L	hsa-miR-1185-2-3p	94.8137	NM_018178
GOLPH3L	hsa-miR-1185-1-3p	94.8137	NM_018178
GOLPH3L	hsa-let-7f-2-3p	94.8137	NM_018178
GOLPH3L	hsa-miR-6758-3p	93.8009	NM_018178
GOLPH3L	hsa-miR-4496	93.0949	NM_018178
GOLPH3L	hsa-miR-34a-5p	91.7169	NM_018178
GOLPH3L	hsa-miR-449a	91.7169	NM_018178
GOLPH3L	hsa-miR-6878-5p	90.9667	NM_018178
GOLPH3L	hsa-miR-4435	89.3091	NM_018178
GOLPH3L	hsa-miR-651-3p	89.2703	NM_018178
GOLPH3L	hsa-miR-2355-3p	89.1951	NM_018178
GOLPH3L	hsa-miR-4774-3p	89.0512	NM_018178
GOLPH3L	hsa-miR-34c-5p	88.7894	NM_018178
GOLPH3L	hsa-miR-449b-5p	88.7894	NM_018178
GOLPH3L	hsa-miR-4261	87.9815	NM_018178
GOLPH3L	hsa-miR-1272	87.8179	NM_018178
GOLPH3L	hsa-miR-5680	86.4334	NM_018178
GOLPH3L	hsa-miR-4493	85.7464	NM_018178
GOLPH3L	hsa-miR-3675-3p	85.2494	NM_018178
GOLPH3L	hsa-miR-3151-5p	84.6957	NM_018178
GOLPH3L	hsa-miR-548l	82.6999	NM_018178
GOLPH3L	hsa-miR-5688	80.7697	NM_018178
GOLPH3L	hsa-miR-495-3p	80.7697	NM_018178
GOLPH3L	hsa-miR-4760-3p	80.7489	NM_018178
GOLPH3L	hsa-miR-29b-2-5p	80.4805	NM_018178

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Motifs and transcription factors (TFs) regulating GOLPH3L

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GOLPH3L	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
GOLPH3L	transfac_pro__M06213	ZNF267 (directAnnotation).
GOLPH3L	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
GOLPH3L	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."