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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: GOLGA7

Summary for GOLGA7

Gene information	Gene symbol	GOLGA7
	Ensembl ID	ENSG00000147533
	Entrez ID	51125
	Gene name	golgin A7
	Synonyms	GCP16\|GOLGA3AP1\|GOLGA7A\|HSPC041
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: GOLGA7

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.294198	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD4+ T cells	0.289246	7.43e-06
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD8+ T cells	0.292424	1.37e-05
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.500531	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.291209	2.80e-45
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.512145	0.00e+00

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Expression of GOLGA7 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GOLGA7

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GOLGA7

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GOLGA7	hsa-miR-7-2-3p	98.5937	NM_001174124
GOLGA7	hsa-miR-7-1-3p	98.5937	NM_001174124
GOLGA7	hsa-miR-302f	95.639	NM_016099
GOLGA7	hsa-miR-4801	94.5997	NM_001174124
GOLGA7	hsa-miR-218-5p	94.5668	NM_001174124
GOLGA7	hsa-miR-3658	94.489	NM_001174124
GOLGA7	hsa-miR-548o-3p	94.3993	NM_001174124
GOLGA7	hsa-miR-1323	94.3993	NM_001174124
GOLGA7	hsa-miR-200c-3p	93.5443	NM_001174124
GOLGA7	hsa-miR-200b-3p	93.5443	NM_001174124
GOLGA7	hsa-miR-429	93.5443	NM_001174124
GOLGA7	hsa-miR-5688	93.1373	NM_001174124
GOLGA7	hsa-miR-5682	92.8708	NM_001174124
GOLGA7	hsa-miR-4731-3p	92.8667	NM_001174124
GOLGA7	hsa-miR-495-3p	91.7535	NM_001174124
GOLGA7	hsa-miR-519e-5p	90.9186	NM_016099
GOLGA7	hsa-miR-515-5p	90.9186	NM_016099
GOLGA7	hsa-miR-137-3p	88.1854	NM_001174124
GOLGA7	hsa-miR-668-3p	87.5688	NM_001174124
GOLGA7	hsa-miR-7110-3p	87.0359	NM_016099
GOLGA7	hsa-miR-8081	86.697	NM_016099
GOLGA7	hsa-miR-561-3p	86.3647	NM_001174124
GOLGA7	hsa-miR-7845-5p	85.7416	NM_001174124
GOLGA7	hsa-miR-6845-3p	85.2296	NM_016099
GOLGA7	hsa-miR-3166	85.1466	NM_001174124
GOLGA7	hsa-miR-4672	84.8789	NM_001174124
GOLGA7	hsa-miR-3941	84.8789	NM_001174124
GOLGA7	hsa-miR-466	83.9076	NM_001174124
GOLGA7	hsa-miR-144-3p	82.4214	NM_016099
GOLGA7	hsa-miR-6807-5p	82.3658	NM_001174124
GOLGA7	hsa-miR-6868-5p	82.0577	NM_001174124
GOLGA7	hsa-miR-760	81.8752	NM_001174124
GOLGA7	hsa-miR-585-5p	81.4793	NM_001174124
GOLGA7	hsa-miR-92a-3p	81.3864	NM_001174124
GOLGA7	hsa-miR-92b-3p	81.3864	NM_001174124
GOLGA7	hsa-miR-32-5p	81.3864	NM_001174124
GOLGA7	hsa-miR-6824-5p	81.264	NM_016099
GOLGA7	hsa-miR-363-3p	81.2627	NM_001174124
GOLGA7	hsa-miR-25-3p	81.2627	NM_001174124
GOLGA7	hsa-miR-367-3p	81.2627	NM_001174124
GOLGA7	hsa-miR-7160-5p	81.0946	NM_001174124
GOLGA7	hsa-miR-770-5p	80.7982	NM_001174124
GOLGA7	hsa-miR-4712-5p	80.7982	NM_001174124
GOLGA7	hsa-miR-4289	80.7923	NM_016099
GOLGA7	hsa-miR-4796-3p	80.3604	NM_001174124
GOLGA7	hsa-miR-937-5p	80.0791	NM_016099

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Motifs and transcription factors (TFs) regulating GOLGA7

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GOLGA7	hdpi__ETV4	ETV4 (directAnnotation).
GOLGA7	cisbp__M02645	ETS1 (directAnnotation).
GOLGA7	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
GOLGA7	hdpi__TP73	TP73 (directAnnotation).
GOLGA7	metacluster_19.7	GMEB1; GMEB2 (inferredBy_Orthology).
GOLGA7	jaspar__MA1122.1	TFDP1 (directAnnotation).
GOLGA7	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
GOLGA7	cisbp__M08198	ELF1 (directAnnotation).
GOLGA7	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
GOLGA7	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
GOLGA7	taipale_tf_pairs__ELK1_FOXI1_WGTTKMCGGAWRTN_CAP	ELK1; FOXI1 (directAnnotation).
GOLGA7	transfac_pro__M02090	E2F4 (directAnnotation).
GOLGA7	metacluster_126.2	ZBTB4; ZBTB4 (directAnnotation).
GOLGA7	kznf__EGR2_Barrera2016.1_PBM	EGR2 (directAnnotation).
GOLGA7	kznf__ZBTB26_Schmitges2016_ChIP-seq	ZBTB26 (directAnnotation).
GOLGA7	swissregulon__hs__EPAS1	EPAS1 (directAnnotation).
GOLGA7	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
GOLGA7	transfac_pro__M02898	SMAD3 (directAnnotation).
GOLGA7	transfac_pro__M02865	GMEB1 (inferredBy_Orthology).
GOLGA7	tfdimers__MD00391	KLF4 (directAnnotation).
GOLGA7	tfdimers__MD00557	MZF1 (directAnnotation).
GOLGA7	cisbp__M01864	EGR1 (inferredBy_Orthology).
GOLGA7	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
GOLGA7	metacluster_135.11	NR2C2 (directAnnotation).
GOLGA7	metacluster_7.13	ZFX (directAnnotation).
GOLGA7	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
GOLGA7	cisbp__M00968	MTF2 (directAnnotation).
GOLGA7	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
GOLGA7	metacluster_160.20	JUND; PRDM15 (directAnnotation).
GOLGA7	cisbp__M00341	PAX6 (directAnnotation).
GOLGA7	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
GOLGA7	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
GOLGA7	cisbp__M00788	ZFY (inferredBy_Orthology).
GOLGA7	hdpi__ZNF304	ZNF304 (directAnnotation).
GOLGA7	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
GOLGA7	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
GOLGA7	transfac_pro__M01199	TRIM28 (directAnnotation).
GOLGA7	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
GOLGA7	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
GOLGA7	transfac_pro__M03806	ZBTB7C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."