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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: GNPTAB

Summary for GNPTAB

Gene information	Gene symbol	GNPTAB
	Ensembl ID	ENSG00000111670
	Entrez ID	79158
	Gene name	N-acetylglucosamine-1-phosphate transferase subunits alpha and beta
	Synonyms	GNPTA\|KIAA1208\|MGC4170
	Gene type	protein_coding
	UniProtAcc	Q3T906

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Dataset with differentially expressed gene: GNPTAB

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.397085	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	0.280446	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	0.259933	1.90e-29
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.549836	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.359896	1.64e-34
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.322616	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD8+ T cells	-0.303243	3.03e-02
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.457223	0.00e+00

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Expression of GNPTAB in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GNPTAB

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GNPTAB

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GNPTAB	hsa-miR-98-5p	95.4431	NM_024312
GNPTAB	hsa-let-7g-5p	95.4431	NM_024312
GNPTAB	hsa-let-7c-5p	95.4431	NM_024312
GNPTAB	hsa-let-7b-5p	95.4431	NM_024312
GNPTAB	hsa-let-7f-5p	95.4431	NM_024312
GNPTAB	hsa-let-7i-5p	95.4431	NM_024312
GNPTAB	hsa-let-7a-5p	95.4431	NM_024312
GNPTAB	hsa-let-7e-5p	95.4431	NM_024312
GNPTAB	hsa-miR-4500	95.3902	NM_024312
GNPTAB	hsa-miR-4458	95.1867	NM_024312
GNPTAB	hsa-let-7d-5p	95.1867	NM_024312
GNPTAB	hsa-miR-194-3p	94.7286	NM_024312
GNPTAB	hsa-miR-7160-5p	94.2223	NM_024312
GNPTAB	hsa-miR-32-3p	92.6932	NM_024312
GNPTAB	hsa-let-7c-3p	92.1016	NM_024312
GNPTAB	hsa-miR-3529-3p	90.1195	NM_024312
GNPTAB	hsa-miR-10522-5p	89.8765	NM_024312
GNPTAB	hsa-miR-7162-3p	89.2164	NM_024312
GNPTAB	hsa-miR-524-5p	89.0232	NM_024312
GNPTAB	hsa-miR-520d-5p	89.0232	NM_024312
GNPTAB	hsa-miR-493-5p	87.7094	NM_024312
GNPTAB	hsa-miR-196a-1-3p	85.9943	NM_024312
GNPTAB	hsa-miR-202-3p	85.1129	NM_024312
GNPTAB	hsa-miR-222-5p	84.0796	NM_024312
GNPTAB	hsa-miR-606	82.2833	NM_024312
GNPTAB	hsa-miR-548n	81.2683	NM_024312
GNPTAB	hsa-miR-4328	80.7121	NM_024312
GNPTAB	hsa-miR-3182	80.5982	NM_024312
GNPTAB	hsa-miR-6844	80.2413	NM_024312

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Motifs and transcription factors (TFs) regulating GNPTAB

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GNPTAB	metacluster_151.2	ZNF23 (directAnnotation).
GNPTAB	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
GNPTAB	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
GNPTAB	hdpi__ETV4	ETV4 (directAnnotation).
GNPTAB	jaspar__MA0748.2	YY2 (directAnnotation).
GNPTAB	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
GNPTAB	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
GNPTAB	cisbp__M00788	ZFY (inferredBy_Orthology).
GNPTAB	transfac_pro__M02913	SP140 (inferredBy_Orthology).
GNPTAB	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
GNPTAB	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
GNPTAB	transfac_pro__M02898	SMAD3 (directAnnotation).
GNPTAB	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
GNPTAB	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
GNPTAB	transfac_pro__M04893	TAF1 (directAnnotation).
GNPTAB	transfac_pro__M00430	E2F1 (directAnnotation).
GNPTAB	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
GNPTAB	transfac_pro__M00938	E2F1 (directAnnotation).
GNPTAB	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
GNPTAB	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
GNPTAB	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
GNPTAB	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
GNPTAB	cisbp__M08198	ELF1 (directAnnotation).
GNPTAB	metacluster_141.4	GLIS2 (directAnnotation).
GNPTAB	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
GNPTAB	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
GNPTAB	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
GNPTAB	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
GNPTAB	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
GNPTAB	transfac_pro__M01253	CNOT3 (directAnnotation).
GNPTAB	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
GNPTAB	jaspar__MA1721.1	ZNF93 (directAnnotation).
GNPTAB	swissregulon__hs__CHD1	CHD1 (directAnnotation).
GNPTAB	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
GNPTAB	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
GNPTAB	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWGNNNNNTCCGGNN_CAP	GCM1; SPDEF (directAnnotation).
GNPTAB	transfac_pro__M01199	TRIM28 (directAnnotation).
GNPTAB	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
GNPTAB	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
GNPTAB	cisbp__M00968	MTF2 (directAnnotation).
GNPTAB	transfac_pro__M01973	PLAG1 (directAnnotation).
GNPTAB	transfac_pro__M12697	ZNF142 (directAnnotation).
GNPTAB	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
GNPTAB	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
GNPTAB	metacluster_24.5	ZNF675; ZNF675 (directAnnotation).
GNPTAB	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
GNPTAB	transfac_pro__M04950	EGR1 (directAnnotation).
GNPTAB	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
GNPTAB	taipale_tf_pairs__ERF_HES7_NCCGGAANNNNNNCACGYGNN_CAP_repr	ERF; HES7 (directAnnotation).
GNPTAB	metacluster_198.3	ZFP64 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."