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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: GNPNAT1

Summary for GNPNAT1

Gene informationGene symbol

GNPNAT1

Ensembl ID

ENSG00000100522

Entrez ID

64841

Gene nameglucosamine-phosphate N-acetyltransferase 1
SynonymsFLJ10607|Gpnat1
Gene typeprotein_coding
UniProtAcc

Q96EK6


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Dataset with differentially expressed gene: GNPNAT1

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE131984_Pac

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)ChemotherapypaclitaxelNAMalignant cells0.3568433.87e-14

GSE139386

H3122 cell lineCell lineLung cancerEML4-ALK fusion-positive non-small cell lung cancer (NSCLC)Targeted therapyceritinibNAMalignant cells-0.2772736.88e-41

GSE131984_JQ1

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapyJQ1NAMalignant cells-0.2781742.66e-12

GSE131984_JQ1Pac

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapyJQ1 + paclitaxelNAMalignant cells-0.4596935.45e-23

GSE131984_JQ1Pal

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapyJQ1 + palbociclibNAMalignant cells-0.3899313.23e-20

GSE131984_Pal

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapypalbociclibNAMalignant cells-0.4751085.36e-25

GSE175716

PDXTumor tissueLiver cancerAdvanced hepatocellular carcinomaTargeted therapysorafenibNAMalignant cells-0.4231020.00e+00

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Expression of GNPNAT1 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to GNPNAT1

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GNPNAT1

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
GNPNAT1hsa-miR-548c-3p98.351NM_198066
GNPNAT1hsa-miR-6512-5p96.1939NM_198066
GNPNAT1hsa-miR-3065-5p95.2673NM_198066
GNPNAT1hsa-miR-545-5p94.6716NM_198066
GNPNAT1hsa-miR-7856-5p94.4411NM_198066
GNPNAT1hsa-miR-548g-5p91.7384NM_198066
GNPNAT1hsa-miR-548f-5p91.7384NM_198066
GNPNAT1hsa-miR-548aj-5p91.7384NM_198066
GNPNAT1hsa-miR-548x-5p91.7384NM_198066
GNPNAT1hsa-miR-7106-5p90.7078NM_198066
GNPNAT1hsa-miR-426789.8467NM_198066
GNPNAT1hsa-miR-374a-5p89.819NM_198066
GNPNAT1hsa-miR-4477b89.0144NM_198066
GNPNAT1hsa-miR-129788.2614NM_198066
GNPNAT1hsa-miR-3677-5p86.5351NM_198066
GNPNAT1hsa-miR-10523-5p86.0971NM_198066
GNPNAT1hsa-miR-607485.7688NM_198066
GNPNAT1hsa-miR-302f85.4284NM_198066
GNPNAT1hsa-miR-374b-5p85.0344NM_198066
GNPNAT1hsa-miR-510-3p83.6941NM_198066
GNPNAT1hsa-miR-477583.691NM_198066
GNPNAT1hsa-miR-447883.6544NM_198066
GNPNAT1hsa-miR-6780a-5p83.3939NM_198066
GNPNAT1hsa-miR-541-5p82.7177NM_198066
GNPNAT1hsa-miR-26b-5p82.604NM_198066
GNPNAT1hsa-miR-26a-5p82.604NM_198066
GNPNAT1hsa-miR-138-1-3p82.4997NM_198066
GNPNAT1hsa-miR-452882.114NM_198066
GNPNAT1hsa-miR-590-3p81.9555NM_198066
GNPNAT1hsa-miR-335-3p81.6919NM_198066
GNPNAT1hsa-miR-30b-3p81.3497NM_198066
GNPNAT1hsa-miR-3689a-3p81.3497NM_198066
GNPNAT1hsa-miR-3689c81.3497NM_198066
GNPNAT1hsa-miR-1273h-5p81.3497NM_198066
GNPNAT1hsa-miR-3689b-3p81.3497NM_198066
GNPNAT1hsa-miR-6779-5p81.3497NM_198066
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Motifs and transcription factors (TFs) regulating GNPNAT1

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
GNPNAT1metacluster_191.2ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
GNPNAT1metacluster_55.3E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
GNPNAT1taipale_tf_pairs__ETS2_RCCGGAAGTG_HTETS2 (directAnnotation).
GNPNAT1dbtfbs__E2F8_representative_N1E2F8 (directAnnotation).
GNPNAT1transfac_pro__M04950EGR1 (directAnnotation).
GNPNAT1metacluster_15.3E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
GNPNAT1metacluster_191.3EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
GNPNAT1taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_reprE2F2 (directAnnotation).
GNPNAT1taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_reprERF; HES7 (directAnnotation).
GNPNAT1taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_reprE2F1; ELK1 (directAnnotation).
GNPNAT1transfac_pro__M00652NRF1 (directAnnotation).
GNPNAT1taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_reprE2F1; HES7 (directAnnotation).
GNPNAT1transfac_pro__M04866HDAC2 (directAnnotation).
GNPNAT1jaspar__MA1122.1TFDP1 (directAnnotation).
GNPNAT1metacluster_166.4BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
GNPNAT1swissregulon__hs__ZBTB14ZBTB14 (directAnnotation).
GNPNAT1metacluster_138.2ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
GNPNAT1metacluster_135.11NR2C2 (directAnnotation).
GNPNAT1metacluster_135.10MBD2; MBD2; MECP2; MECP2 (directAnnotation).
GNPNAT1tfdimers__MD00038TFAP2C (directAnnotation).
GNPNAT1metacluster_144.3ZNF704; ZNF704 (directAnnotation).
GNPNAT1metacluster_7.13ZFX (directAnnotation).
GNPNAT1kznf__ZNF730_Imbeault2017_RP_RCADEZNF730 (directAnnotation).
GNPNAT1cisbp__M00968MTF2 (directAnnotation).
GNPNAT1metacluster_155.23BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
GNPNAT1metacluster_160.20JUND; PRDM15 (directAnnotation).
GNPNAT1cisbp__M00341PAX6 (directAnnotation).
GNPNAT1metacluster_198.3ZFP64 (directAnnotation).
GNPNAT1metacluster_141.5NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
GNPNAT1metacluster_151.1KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
GNPNAT1jaspar__MA0185.1DEAF1 (inferredBy_Orthology).
GNPNAT1metacluster_61.1DEAF1; DEAF1 (directAnnotation).
GNPNAT1cisbp__M00788ZFY (inferredBy_Orthology).
GNPNAT1kznf__ZNF213_Schmitges2016_RCADEZNF213 (directAnnotation).
GNPNAT1metacluster_175.1ZNF283 (directAnnotation).
GNPNAT1hdpi__ZNF304ZNF304 (directAnnotation).
GNPNAT1transfac_pro__M02844BCL6B (inferredBy_Orthology).
GNPNAT1metacluster_125.2TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
GNPNAT1metacluster_133.1ZNF304; ZNF304; ZSCAN22 (directAnnotation).
GNPNAT1transfac_pro__M01199TRIM28 (directAnnotation).
GNPNAT1kznf__ZNF682_Isakova2017_SMiLE-seqZNF682 (directAnnotation).
GNPNAT1metacluster_151.2ZNF23 (directAnnotation).
GNPNAT1transfac_public__M00189TFAP2A; TFAP2B; TFAP2C (directAnnotation).
GNPNAT1transfac_pro__M01219SP1 (directAnnotation). SP3 (inferredBy_Orthology).
GNPNAT1transfac_pro__M03806ZBTB7C (directAnnotation).
GNPNAT1transfac_pro__M00915TFAP2A; TFAP2B; TFAP2C (directAnnotation).
GNPNAT1metacluster_166.2ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
GNPNAT1taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAPETV5; HOXA2 (directAnnotation).
GNPNAT1taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAPELK3; FOXO1 (directAnnotation).
GNPNAT1transfac_pro__M04826EP300 (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."