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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: GNG10

Summary for GNG10

Gene information	Gene symbol	GNG10
	Ensembl ID	ENSG00000242616
	Entrez ID	2790
	Gene name	G protein subunit gamma 10
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P50151

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Dataset with differentially expressed gene: GNG10

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	0.317226	1.09e-07

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Expression of GNG10 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GNG10

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GNG10

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GNG10	hsa-miR-526b-5p	96.1521	NM_001017998
GNG10	hsa-miR-548az-5p	94.5567	NM_001017998
GNG10	hsa-miR-548t-5p	94.5567	NM_001017998
GNG10	hsa-miR-3667-3p	93.9471	NM_001198664
GNG10	hsa-miR-494-3p	92.8265	NM_001017998
GNG10	hsa-miR-6868-3p	91.5875	NM_001198664
GNG10	hsa-miR-3924	91.2953	NM_001198664
GNG10	hsa-miR-551b-5p	91.0922	NM_001017998
GNG10	hsa-miR-3657	89.1448	NM_001198664
GNG10	hsa-miR-124-3p	88.6164	NM_001017998
GNG10	hsa-miR-506-3p	88.6164	NM_001017998
GNG10	hsa-miR-4729	87.8671	NM_001198664
GNG10	hsa-miR-3675-3p	87.6638	NM_001198664
GNG10	hsa-miR-122b-5p	86.4207	NM_001017998
GNG10	hsa-miR-6750-3p	86.3808	NM_001198664
GNG10	hsa-miR-153-5p	85.5733	NM_001198664
GNG10	hsa-miR-4679	85.2393	NM_001198664
GNG10	hsa-miR-30b-5p	85.2244	NM_001017998
GNG10	hsa-miR-30d-5p	85.2244	NM_001017998
GNG10	hsa-miR-30c-5p	85.2244	NM_001017998
GNG10	hsa-miR-30e-5p	85.2244	NM_001017998
GNG10	hsa-miR-30a-5p	85.2244	NM_001017998
GNG10	hsa-miR-520f-5p	84.3332	NM_001198664
GNG10	hsa-miR-6792-5p	83.936	NM_001198664
GNG10	hsa-miR-3611	81.9061	NM_001198664
GNG10	hsa-miR-4446-3p	81.6325	NM_001198664

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Motifs and transcription factors (TFs) regulating GNG10

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GNG10	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
GNG10	taipale_tf_pairs__TFAP2C_ELK1_NGCCTNNGGSNNCGGAAGYN_CAP_repr	ELK1; TFAP2C (directAnnotation).
GNG10	transfac_pro__M01890	STAT5A (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."