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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: GNAL

Summary for GNAL

Gene information	Gene symbol	GNAL
	Ensembl ID	ENSG00000141404
	Entrez ID	2774
	Gene name	G protein subunit alpha L
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P38405

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Dataset with differentially expressed gene: GNAL

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.02318	2.27e-03

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Expression of GNAL in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GNAL

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GNAL

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GNAL	hsa-miR-6867-5p	97.0626	NM_001142339
GNAL	hsa-miR-3529-3p	96.7862	NM_001142339
GNAL	hsa-miR-6516-5p	94.4403	NM_001142339
GNAL	hsa-miR-7107-3p	92.4387	NM_001142339
GNAL	hsa-miR-6753-3p	92.4387	NM_001142339
GNAL	hsa-miR-3691-5p	91.5712	NM_001142339
GNAL	hsa-miR-1197	91.4037	NM_001142339
GNAL	hsa-miR-6738-3p	90.8898	NM_001142339
GNAL	hsa-miR-548u	90.5329	NM_001142339
GNAL	hsa-let-7g-3p	89.7434	NM_001142339
GNAL	hsa-let-7a-2-3p	89.7434	NM_001142339
GNAL	hsa-miR-7161-5p	89.2317	NM_001142339
GNAL	hsa-miR-153-5p	89.0717	NM_001142339
GNAL	hsa-miR-939-3p	88.9925	NM_001142339
GNAL	hsa-miR-942-5p	88.5227	NM_001142339
GNAL	hsa-miR-653-5p	86.703	NM_001142339
GNAL	hsa-miR-4659a-3p	86.3566	NM_001142339
GNAL	hsa-miR-4659b-3p	86.3566	NM_001142339
GNAL	hsa-miR-3619-5p	85.4124	NM_001142339
GNAL	hsa-miR-214-3p	85.4124	NM_001142339
GNAL	hsa-miR-506-3p	85.3987	NM_001142339
GNAL	hsa-miR-124-3p	85.3987	NM_001142339
GNAL	hsa-miR-761	84.7671	NM_001142339
GNAL	hsa-miR-5582-5p	84.5177	NM_001142339
GNAL	hsa-miR-6073	84.173	NM_001142339
GNAL	hsa-miR-5001-3p	83.9065	NM_001142339
GNAL	hsa-miR-1255b-5p	83.4661	NM_001142339
GNAL	hsa-miR-1255a	83.4661	NM_001142339
GNAL	hsa-miR-1244	82.8749	NM_001142339
GNAL	hsa-miR-6760-5p	82.4857	NM_001142339
GNAL	hsa-miR-4766-5p	82.4775	NM_001142339
GNAL	hsa-miR-4279	81.113	NM_001142339
GNAL	hsa-let-7b-3p	80.4768	NM_001142339
GNAL	hsa-let-7a-3p	80.4768	NM_001142339
GNAL	hsa-let-7f-1-3p	80.4768	NM_001142339
GNAL	hsa-miR-98-3p	80.4768	NM_001142339
GNAL	hsa-miR-4524b-3p	80.1861	NM_001142339
GNAL	hsa-miR-340-5p	80.1342	NM_001142339

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Motifs and transcription factors (TFs) regulating GNAL

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GNAL	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
GNAL	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
GNAL	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
GNAL	transfac_pro__M04617	ZBTB7A (directAnnotation).
GNAL	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
GNAL	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
GNAL	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
GNAL	transfac_pro__M07387	ZBTB7A (directAnnotation).
GNAL	transfac_pro__M07436	WT1 (directAnnotation).
GNAL	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
GNAL	transfac_pro__M00716	ZBTB14 (directAnnotation).
GNAL	swissregulon__hs__CHD1	CHD1 (directAnnotation).
GNAL	transfac_pro__M04893	TAF1 (directAnnotation).
GNAL	transfac_pro__M03876	ZBTB33 (directAnnotation).
GNAL	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
GNAL	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."