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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: GNAI2

Summary for GNAI2

Gene information	Gene symbol	GNAI2
	Ensembl ID	ENSG00000114353
	Entrez ID	2771
	Gene name	G protein subunit alpha i2
	Synonyms	GIP\|GNAI2B
	Gene type	protein_coding
	UniProtAcc	P04899

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Dataset with differentially expressed gene: GNAI2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.593072	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	-0.347888	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	B cells	0.257533	7.83e-06
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	cDCs	0.252014	1.17e-02
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.251298	9.26e-11
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	post	cDCs	-0.462463	6.86e-04
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	post	CD8+ T cells	0.255068	0.00e+00
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	post	CD4+ T cells	0.265617	2.97e-40
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.585754	7.56e-05
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.36926	5.70e-12
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	NK cells	-0.269564	2.40e-12
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.748579	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	0.402385	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-1.33603	1.95e-06
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD8+ T cells	-0.301772	3.09e-02
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.981384	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.537146	3.86e-42
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.350924	0.00e+00

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Expression of GNAI2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GNAI2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GNAI2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GNAI2	hsa-miR-4498	96.8701	NM_001166425
GNAI2	hsa-miR-4492	96.5942	NM_001166425
GNAI2	hsa-miR-4763-3p	95.8921	NM_001166425
GNAI2	hsa-miR-762	95.7566	NM_001166425
GNAI2	hsa-miR-5001-5p	95.2194	NM_001166425
GNAI2	hsa-miR-1207-5p	93.4511	NM_001166425
GNAI2	hsa-miR-4731-5p	90.8068	NM_001166425
GNAI2	hsa-miR-30d-5p	90.1994	NM_001166425
GNAI2	hsa-miR-30a-5p	90.1994	NM_001166425
GNAI2	hsa-miR-30c-5p	90.1994	NM_001166425
GNAI2	hsa-miR-30e-5p	90.1994	NM_001166425
GNAI2	hsa-miR-30b-5p	90.1994	NM_001166425
GNAI2	hsa-miR-12136	89.6427	NM_001166425
GNAI2	hsa-miR-520f-5p	88.7291	NM_001166425
GNAI2	hsa-miR-6516-5p	86.7983	NM_001166425
GNAI2	hsa-miR-4328	86.0512	NM_001166425
GNAI2	hsa-miR-185-3p	85.5842	NM_001166425
GNAI2	hsa-miR-138-5p	85.0915	NM_001166425
GNAI2	hsa-miR-218-5p	84.5856	NM_001166425
GNAI2	hsa-miR-587	83.6842	NM_001166425
GNAI2	hsa-miR-6885-5p	83.154	NM_001166425
GNAI2	hsa-miR-153-5p	82.9389	NM_001166425
GNAI2	hsa-miR-548au-3p	81.8093	NM_001166425
GNAI2	hsa-miR-328-5p	81.3694	NM_001166425
GNAI2	hsa-miR-4777-5p	80.7358	NM_001166425
GNAI2	hsa-miR-7113-3p	80.5031	NM_001166425
GNAI2	hsa-miR-5009-5p	80.2599	NM_001166425

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Motifs and transcription factors (TFs) regulating GNAI2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GNAI2	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
GNAI2	jaspar__MA1483.2	ELF2 (directAnnotation).
GNAI2	hdpi__ETV4	ETV4 (directAnnotation).
GNAI2	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
GNAI2	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
GNAI2	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
GNAI2	taipale_tf_pairs__ETV2_HES7_NNCACGTGNNNNNCGGAWRY_CAP_repr	ETV2; HES7 (directAnnotation).
GNAI2	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
GNAI2	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
GNAI2	swissregulon__hs__ELF2	ELF2 (directAnnotation).
GNAI2	swissregulon__hs__ETV6	ETV6 (directAnnotation).
GNAI2	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
GNAI2	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
GNAI2	jaspar__MA0748.2	YY2 (directAnnotation).
GNAI2	metacluster_182.10	ZFX (directAnnotation).
GNAI2	metacluster_2.6	IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF3; IRF3; IRF3; IRF3; IRF3; IRF3; IRF4; IRF4; IRF4; IRF4; IRF4; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF6; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; STAT1; STAT2; STAT2; STAT2; STAT2; ZNF426; ZNF71 (directAnnotation). IRF1; IRF1; IRF3; IRF8 (inferredBy_Orthology).
GNAI2	metacluster_167.7	IRF8 (inferredBy_Orthology).
GNAI2	metacluster_2.7	IRF1; IRF1; IRF2; IRF2; IRF3; IRF4; IRF5; IRF6; IRF7; IRF7; IRF8; IRF8; IRF9; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; STAT1; STAT1; STAT2 (directAnnotation). PRDM1; PRDM1; PRDM1 (inferredBy_Orthology).
GNAI2	metacluster_161.45	HOXD4 (directAnnotation).
GNAI2	metacluster_2.9	IRF2; IRF2; IRF2; PRDM1; PRDM1 (directAnnotation). PRDM1 (inferredBy_Orthology).
GNAI2	metacluster_117.5	ZFP41 (directAnnotation). GATA5; ZFP41 (inferredBy_Orthology).
GNAI2	metacluster_172.21	SPDEF (inferredBy_Orthology).
GNAI2	tfdimers__MD00007	E2F1; IRF8 (directAnnotation).
GNAI2	metacluster_161.39	MSX1 (directAnnotation).
GNAI2	metacluster_161.13	ISX (directAnnotation).
GNAI2	metacluster_161.51	PDX1 (directAnnotation).
GNAI2	metacluster_161.6	ALX3 (directAnnotation).
GNAI2	hocomoco__DPRX_HUMAN.H11MO.0.D	DPRX (directAnnotation).
GNAI2	metacluster_160.15	ATF5; ATF5 (directAnnotation).
GNAI2	transfac_pro__M06458	ZNF441 (directAnnotation).
GNAI2	metacluster_9.34	HOXA5 (directAnnotation).
GNAI2	taipale_tf_pairs__TEAD4_HOXA2_RCATTCNNNNNNCATTA_CAP	HOXA2; TEAD4 (directAnnotation).
GNAI2	taipale_tf_pairs__TEAD4_HOXA3_RCATTCNNNNNNCATTA_CAP	HOXA3; TEAD4 (directAnnotation).
GNAI2	metacluster_161.33	DLX5 (directAnnotation).
GNAI2	jaspar__MA1561.1	SOX12 (directAnnotation).
GNAI2	metacluster_161.34	MNX1 (directAnnotation).
GNAI2	metacluster_161.71	HOXD3 (directAnnotation).
GNAI2	transfac_pro__M01658	RUNX1 (directAnnotation).
GNAI2	tfdimers__MD00602	MYB; STAT6 (directAnnotation).
GNAI2	metacluster_161.44	HOXA4 (directAnnotation).
GNAI2	transfac_pro__M02084	RUNX1 (directAnnotation).
GNAI2	hdpi__PRRX1	PRRX1 (directAnnotation).
GNAI2	metacluster_27.20	ZNF708; ZNF787; ZNF787; ZNF85 (directAnnotation).
GNAI2	transfac_pro__M00436	PDX1 (directAnnotation).
GNAI2	metacluster_161.50	HOXA2 (directAnnotation).
GNAI2	taipale_cyt_meth__TLX3_NAATTGNNNNNNNNNNCAATTN_FL_repr	TLX3 (directAnnotation).
GNAI2	metacluster_161.54	HOXA5 (directAnnotation).
GNAI2	tfdimers__MD00095	ELF1; NEUROD1 (directAnnotation).
GNAI2	metacluster_47.1	E4F1; SPDEF; SPDEF (directAnnotation).
GNAI2	swissregulon__mm__Nr4a1	NR4A1 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."