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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: GNA12

Summary for GNA12

Gene information	Gene symbol	GNA12
	Ensembl ID	ENSG00000146535
	Entrez ID	2768
	Gene name	G protein subunit alpha 12
	Synonyms	gep
	Gene type	protein_coding
	UniProtAcc	Q03113

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Dataset with differentially expressed gene: GNA12

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.451066	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.276265	1.41e-13

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Expression of GNA12 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GNA12

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GNA12

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GNA12	hsa-miR-222-5p	98.747	NM_007353
GNA12	hsa-miR-4743-3p	97.6573	NM_001282440
GNA12	hsa-miR-3129-5p	97.3469	NM_007353
GNA12	hsa-miR-199b-3p	97.3469	NM_007353
GNA12	hsa-miR-199a-3p	97.3469	NM_007353
GNA12	hsa-miR-3928-3p	94.4253	NM_007353
GNA12	hsa-miR-936	93.4182	NM_007353
GNA12	hsa-miR-8485	91.3003	NM_007353
GNA12	hsa-miR-3915	89.7341	NM_007353
GNA12	hsa-miR-215-3p	88.5048	NM_001282440
GNA12	hsa-miR-7106-3p	86.7843	NM_001282440
GNA12	hsa-miR-362-3p	86.3704	NM_007353
GNA12	hsa-miR-329-3p	86.3704	NM_007353
GNA12	hsa-miR-5007-5p	86.236	NM_001282440
GNA12	hsa-miR-30d-3p	85.4496	NM_007353
GNA12	hsa-miR-30e-3p	85.4496	NM_007353
GNA12	hsa-miR-30a-3p	85.4496	NM_007353
GNA12	hsa-miR-4652-3p	85.138	NM_001282440
GNA12	hsa-miR-6813-5p	84.5959	NM_007353
GNA12	hsa-miR-6085	84.5959	NM_007353
GNA12	hsa-miR-519e-5p	81.244	NM_001282440
GNA12	hsa-miR-515-5p	81.244	NM_001282440
GNA12	hsa-miR-6867-5p	81.1774	NM_001282440

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Motifs and transcription factors (TFs) regulating GNA12

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GNA12	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
GNA12	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
GNA12	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
GNA12	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
GNA12	jaspar__MA1721.1	ZNF93 (directAnnotation).
GNA12	metacluster_151.2	ZNF23 (directAnnotation).
GNA12	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
GNA12	transfac_pro__M01199	TRIM28 (directAnnotation).
GNA12	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
GNA12	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
GNA12	transfac_pro__M01253	CNOT3 (directAnnotation).
GNA12	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
GNA12	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
GNA12	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
GNA12	cisbp__M00968	MTF2 (directAnnotation).
GNA12	metacluster_7.13	ZFX (directAnnotation).
GNA12	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
GNA12	swissregulon__hs__CHD1	CHD1 (directAnnotation).
GNA12	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
GNA12	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
GNA12	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
GNA12	cisbp__M01863	ZNF711 (inferredBy_Orthology).
GNA12	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
GNA12	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
GNA12	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
GNA12	transfac_pro__M04817	ZBTB33 (directAnnotation).
GNA12	cisbp__M00788	ZFY (inferredBy_Orthology).
GNA12	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
GNA12	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
GNA12	transfac_pro__M01973	PLAG1 (directAnnotation).
GNA12	transfac_pro__M00514	ATF4 (directAnnotation).
GNA12	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
GNA12	transfac_pro__M02898	SMAD3 (directAnnotation).
GNA12	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
GNA12	jaspar__MA0079.5	SP1 (directAnnotation).
GNA12	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."