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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: GMPR

Summary for GMPR

Gene information	Gene symbol	GMPR
	Ensembl ID	ENSG00000137198
	Entrez ID	2766
	Gene name	guanosine monophosphate reductase
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P36959

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Dataset with differentially expressed gene: GMPR

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.28204	2.10e-02
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	0.279488	5.31e-14
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	0.621389	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.271234	8.92e-36

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Expression of GMPR in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GMPR

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GMPR

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GMPR	hsa-miR-4311	97.722	NM_006877
GMPR	hsa-miR-656-3p	88.4313	NM_006877
GMPR	hsa-miR-4528	87.8152	NM_006877
GMPR	hsa-miR-1264	87.5636	NM_006877
GMPR	hsa-miR-5681a	80.8666	NM_006877

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Motifs and transcription factors (TFs) regulating GMPR

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GMPR	metacluster_151.2	ZNF23 (directAnnotation).
GMPR	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
GMPR	transfac_pro__M06619	ZNF669 (directAnnotation).
GMPR	transfac_pro__M05696	ZSCAN20 (directAnnotation).
GMPR	dbtfbs__ZNF157_HEK293_ENCSR564YYW_merged_N1	ZNF157 (directAnnotation).
GMPR	metacluster_72.10	ZNF697 (directAnnotation).
GMPR	metacluster_160.6	SMARCA5 (directAnnotation). SMARCA5 (inferredBy_Orthology).
GMPR	transfac_pro__M05585	HIC2 (directAnnotation).
GMPR	tfdimers__MD00275	POU2F1; TFAP2A (directAnnotation).
GMPR	metacluster_27.6	ZNF410; ZNF410 (directAnnotation).
GMPR	hocomoco__FOXJ3_HUMAN.H11MO.1.B	FOXJ3 (directAnnotation).
GMPR	taipale_tf_pairs__HOXB2_SPDEF_ANCCGGATNNNNNNMATTA_CAP_repr	HOXB2; SPDEF (directAnnotation).
GMPR	taipale_tf_pairs__PITX1_FIGLA_TAATCCNNNNCASSTG_CAP_repr	FIGLA; PITX1 (directAnnotation).
GMPR	tfdimers__MD00271	MAFA; PITX3 (directAnnotation).
GMPR	transfac_pro__M06858	ZNF224 (directAnnotation).
GMPR	transfac_pro__M06543	ZNF418 (directAnnotation).
GMPR	transfac_pro__M06508	ZNF114 (directAnnotation).
GMPR	metacluster_127.3	FOXO1; FOXO3; FOXO4 (directAnnotation).
GMPR	taipale_tf_pairs__TEAD4_CEBPD_RGWATGYNNTTRCGYAAN_CAP	CEBPD; TEAD4 (directAnnotation).
GMPR	transfac_pro__M05845	ZSCAN29 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
GMPR	"Guanosine-5'-Monophosphate"	DB01972	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."