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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: GMFB

Summary for GMFB

Gene information	Gene symbol	GMFB
	Ensembl ID	ENSG00000197045
	Entrez ID	2764
	Gene name	glia maturation factor beta
	Synonyms	GMF
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: GMFB

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.574611	0.00e+00

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Expression of GMFB in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GMFB

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GMFB

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GMFB	hsa-miR-7-2-3p	98.9708	NM_004124
GMFB	hsa-miR-7-1-3p	98.9708	NM_004124
GMFB	hsa-miR-4261	97.769	NM_004124
GMFB	hsa-miR-4496	97.6089	NM_004124
GMFB	hsa-miR-4712-5p	97.1918	NM_004124
GMFB	hsa-miR-770-5p	97.1918	NM_004124
GMFB	hsa-miR-507	96.8406	NM_004124
GMFB	hsa-miR-147b-5p	96.6615	NM_004124
GMFB	hsa-miR-6719-3p	96.3344	NM_004124
GMFB	hsa-miR-557	95.9486	NM_004124
GMFB	hsa-miR-5680	95.2267	NM_004124
GMFB	hsa-miR-513b-5p	95.1018	NM_004124
GMFB	hsa-miR-6891-5p	94.7935	NM_004124
GMFB	hsa-miR-3173-3p	94.5207	NM_004124
GMFB	hsa-miR-12118	94.5207	NM_004124
GMFB	hsa-miR-9902	94.1999	NM_004124
GMFB	hsa-miR-145-5p	93.8552	NM_004124
GMFB	hsa-miR-5195-3p	93.8552	NM_004124
GMFB	hsa-miR-10394-5p	93.533	NM_004124
GMFB	hsa-miR-1205	93.533	NM_004124
GMFB	hsa-miR-5688	93.4087	NM_004124
GMFB	hsa-miR-125b-2-3p	92.8084	NM_004124
GMFB	hsa-miR-148a-3p	92.6886	NM_004124
GMFB	hsa-miR-152-3p	92.6886	NM_004124
GMFB	hsa-miR-148b-3p	92.6886	NM_004124
GMFB	hsa-miR-26a-5p	92.5562	NM_004124
GMFB	hsa-miR-26b-5p	92.5562	NM_004124
GMFB	hsa-miR-6888-5p	92.4188	NM_004124
GMFB	hsa-miR-1297	92.3694	NM_004124
GMFB	hsa-miR-5692a	92.1573	NM_004124
GMFB	hsa-miR-495-3p	92.0487	NM_004124
GMFB	hsa-miR-212-3p	91.6965	NM_004124
GMFB	hsa-miR-132-3p	91.6965	NM_004124
GMFB	hsa-miR-4465	91.4669	NM_004124
GMFB	hsa-miR-506-3p	91.0814	NM_004124
GMFB	hsa-miR-124-3p	91.0814	NM_004124
GMFB	hsa-miR-3680-3p	90.5146	NM_004124
GMFB	hsa-miR-450b-5p	90.5146	NM_004124
GMFB	hsa-miR-651-5p	89.8675	NM_004124
GMFB	hsa-miR-4780	89.6367	NM_004124
GMFB	hsa-miR-509-3-5p	89.2194	NM_004124
GMFB	hsa-miR-509-5p	89.2194	NM_004124
GMFB	hsa-miR-4804-3p	88.9039	NM_004124
GMFB	hsa-miR-651-3p	88.3083	NM_004124
GMFB	hsa-miR-4418	88.0347	NM_004124
GMFB	hsa-miR-513a-5p	87.4325	NM_004124
GMFB	hsa-miR-6499-3p	87.4237	NM_004124
GMFB	hsa-miR-548g-3p	87.2672	NM_004124
GMFB	hsa-miR-514b-5p	86.9943	NM_004124
GMFB	hsa-miR-513c-5p	86.9943	NM_004124

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Motifs and transcription factors (TFs) regulating GMFB

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GMFB	hdpi__ETV4	ETV4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."