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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: GMEB1

Summary for GMEB1

Gene information	Gene symbol	GMEB1
	Ensembl ID	ENSG00000162419
	Entrez ID	10691
	Gene name	glucocorticoid modulatory element binding protein 1
	Synonyms	P96PIF\|PIF96
	Gene type	protein_coding
	UniProtAcc	Q9Y692

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Dataset with differentially expressed gene: GMEB1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.316683	2.15e-27

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Expression of GMEB1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GMEB1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GMEB1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GMEB1	hsa-miR-4481	96.8474	NM_006582
GMEB1	hsa-miR-7-1-3p	96.7277	NM_001319674
GMEB1	hsa-miR-7-2-3p	96.7277	NM_001319674
GMEB1	hsa-miR-4745-5p	95.8087	NM_006582
GMEB1	hsa-miR-4297	95.7097	NM_001319674
GMEB1	hsa-miR-6833-5p	93.7542	NM_006582
GMEB1	hsa-miR-4491	93.5166	NM_006582
GMEB1	hsa-miR-4657	93.5166	NM_006582
GMEB1	hsa-miR-3912-5p	90.5807	NM_001319674
GMEB1	hsa-miR-5093	90.3286	NM_006582
GMEB1	hsa-miR-5581-5p	90.1462	NM_001319674
GMEB1	hsa-miR-520a-5p	87.98	NM_006582
GMEB1	hsa-miR-525-5p	87.98	NM_006582
GMEB1	hsa-miR-4648	87.744	NM_006582
GMEB1	hsa-miR-4298	87.5783	NM_006582
GMEB1	hsa-miR-1302	87.5783	NM_006582
GMEB1	hsa-miR-935	87.2548	NM_001319674
GMEB1	hsa-miR-3529-3p	85.022	NM_006582
GMEB1	hsa-miR-6734-3p	83.2644	NM_006582
GMEB1	hsa-miR-10523-5p	82.164	NM_001319674
GMEB1	hsa-miR-204-5p	81.9242	NM_001319674
GMEB1	hsa-miR-211-5p	81.9242	NM_001319674

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Motifs and transcription factors (TFs) regulating GMEB1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GMEB1	metacluster_135.11	NR2C2 (directAnnotation).
GMEB1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
GMEB1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
GMEB1	metacluster_7.13	ZFX (directAnnotation).
GMEB1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
GMEB1	cisbp__M00968	MTF2 (directAnnotation).
GMEB1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
GMEB1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
GMEB1	cisbp__M00341	PAX6 (directAnnotation).
GMEB1	metacluster_198.3	ZFP64 (directAnnotation).
GMEB1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
GMEB1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
GMEB1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
GMEB1	cisbp__M00788	ZFY (inferredBy_Orthology).
GMEB1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
GMEB1	metacluster_175.1	ZNF283 (directAnnotation).
GMEB1	hdpi__ZNF304	ZNF304 (directAnnotation).
GMEB1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
GMEB1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
GMEB1	transfac_pro__M01199	TRIM28 (directAnnotation).
GMEB1	metacluster_151.2	ZNF23 (directAnnotation).
GMEB1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
GMEB1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
GMEB1	transfac_pro__M03806	ZBTB7C (directAnnotation).
GMEB1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
GMEB1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	down	Malignant cells	GSE175716	NA

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."