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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: GLYR1

Summary for GLYR1

Gene informationGene symbol

GLYR1

Ensembl ID

ENSG00000140632

Entrez ID

84656

Gene nameglyoxylate reductase 1 homolog
SynonymsBM045|HIBDL|N-PAC|NP60
Gene typeprotein_coding
UniProtAcc

NA


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Dataset with differentially expressed gene: GLYR1

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE139386

H3122 cell lineCell lineLung cancerEML4-ALK fusion-positive non-small cell lung cancer (NSCLC)Targeted therapyceritinibNAMalignant cells-0.3245690.00e+00

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Expression of GLYR1 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to GLYR1

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GLYR1

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
GLYR1hsa-miR-6867-5p100NM_001324097
GLYR1hsa-miR-505-3p97.1947NM_032569
GLYR1hsa-miR-92a-3p93.2835NM_032569
GLYR1hsa-miR-92b-3p93.2835NM_032569
GLYR1hsa-miR-32-5p93.2835NM_032569
GLYR1hsa-miR-4766-5p93.1729NM_032569
GLYR1hsa-miR-6853-3p93.1199NM_032569
GLYR1hsa-miR-367-3p92.9909NM_032569
GLYR1hsa-miR-25-3p92.9909NM_032569
GLYR1hsa-miR-363-3p92.9909NM_032569
GLYR1hsa-miR-5196-5p92.6606NM_032569
GLYR1hsa-miR-4747-5p92.6606NM_032569
GLYR1hsa-miR-4776-3p92.1921NM_032569
GLYR1hsa-miR-330-3p87.9408NM_032569
GLYR1hsa-miR-335-5p87.7222NM_032569
GLYR1hsa-miR-806385.8621NM_032569
GLYR1hsa-miR-453385.3797NM_032569
GLYR1hsa-miR-6852-5p84.2892NM_032569
GLYR1hsa-miR-548p83.9301NM_032569
GLYR1hsa-miR-7152-3p83.5547NM_032569
GLYR1hsa-miR-1213582.9066NM_032569
GLYR1hsa-miR-132481.7002NM_032569
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Motifs and transcription factors (TFs) regulating GLYR1

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
GLYR1metacluster_191.2ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
GLYR1taipale_tf_pairs__ETS2_RCCGGAAGTG_HTETS2 (directAnnotation).
GLYR1jaspar__MA1483.2ELF2 (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."