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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: GLUD1

Summary for GLUD1

Gene information	Gene symbol	GLUD1
	Ensembl ID	ENSG00000148672
	Entrez ID	2746
	Gene name	glutamate dehydrogenase 1
	Synonyms	GDH\|GDH1\|GLUD\|hGDH1
	Gene type	protein_coding
	UniProtAcc	P00367

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Dataset with differentially expressed gene: GLUD1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD4+ T cells	0.359597	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.26958	1.62e-18
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.314323	1.40e-45

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Expression of GLUD1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GLUD1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GLUD1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GLUD1	hsa-miR-3163	99.6161	NM_001318900
GLUD1	hsa-miR-548an	98.0697	NM_001318900
GLUD1	hsa-miR-4666a-5p	97.8245	NM_001318900
GLUD1	hsa-miR-524-5p	96.8197	NM_001318900
GLUD1	hsa-miR-520d-5p	96.8197	NM_001318900
GLUD1	hsa-miR-935	95.1755	NM_001318900
GLUD1	hsa-miR-466	92.273	NM_001318900
GLUD1	hsa-miR-8081	91.5022	NM_001318900
GLUD1	hsa-miR-4495	91.2552	NM_001318900
GLUD1	hsa-miR-4796-3p	90.5575	NM_001318906
GLUD1	hsa-miR-4533	89.7466	NM_001318906
GLUD1	hsa-miR-1208	88.1101	NM_001318906
GLUD1	hsa-miR-183-3p	87.9119	NM_001318906
GLUD1	hsa-miR-6503-5p	86.8749	NM_001318906
GLUD1	hsa-miR-4527	86.8749	NM_001318906
GLUD1	hsa-miR-3692-5p	86.8165	NM_001318906
GLUD1	hsa-miR-4789-3p	86.7372	NM_001318900
GLUD1	hsa-miR-6768-3p	86.6765	NM_001318900
GLUD1	hsa-miR-9902	85.9411	NM_001318906
GLUD1	hsa-miR-12116	84.176	NM_001318906
GLUD1	hsa-miR-7850-5p	84.0795	NM_001318900
GLUD1	hsa-miR-26a-1-3p	83.3636	NM_001318906
GLUD1	hsa-miR-26a-2-3p	83.3636	NM_001318906
GLUD1	hsa-miR-4526	82.2042	NM_001318906
GLUD1	hsa-miR-3660	82.2042	NM_001318906
GLUD1	hsa-miR-3613-3p	81.7345	NM_001318906
GLUD1	hsa-miR-3158-5p	81.7049	NM_001318906
GLUD1	hsa-miR-1468-3p	81.5233	NM_001318900
GLUD1	hsa-miR-1244	80.9945	NM_001318906
GLUD1	hsa-miR-4733-3p	80.9272	NM_001318906
GLUD1	hsa-miR-4751	80.6453	NM_001318900
GLUD1	hsa-miR-6877-3p	80.5435	NM_001318906
GLUD1	hsa-miR-6819-3p	80.5435	NM_001318906
GLUD1	hsa-miR-937-5p	80.3493	NM_001318900

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Motifs and transcription factors (TFs) regulating GLUD1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GLUD1	taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAP	ATF4; TEF (directAnnotation).
GLUD1	taipale_tf_pairs__ATF4_CEBPD_NGATGATGCAATNN_CAP	ATF4; CEBPD (directAnnotation).
GLUD1	metacluster_156.2	ATF3; ATF4; ATF4; ATF4; ATF4; ATF4; ATF4; CEBPG; CEBPG; DDIT3; MYC (directAnnotation). ATF4; ATF4; ATF4; CEBPG; DDIT3 (inferredBy_Orthology).
GLUD1	taipale_tf_pairs__ATF4_CEBPB_NNATGAYGCAAYN_CAP	ATF4; CEBPB (directAnnotation).
GLUD1	taipale_tf_pairs__ETV2_SOX15_RSCGGAANNNNNNNYWTTGT_CAP_repr	ETV2; SOX15 (directAnnotation).
GLUD1	transfac_pro__M06806	PEG3 (directAnnotation).
GLUD1	metacluster_32.25	ZNF287 (directAnnotation).
GLUD1	metacluster_130.2	ZNF182; ZNF22; ZNF225; ZNF225; ZNF285; ZNF362; ZNF362; ZNF384; ZNF487; ZNF512; ZNF570; ZNF613 (directAnnotation). ZNF384 (inferredBy_Orthology).
GLUD1	transfac_pro__M06499	ZNF383 (directAnnotation).
GLUD1	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
GLUD1	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
GLUD1	transfac_pro__M00801	ATF1; ATF2; ATF3; ATF4; ATF7; CREB1; CREM (directAnnotation). ATF7-NPFF (inferredBy_Orthology).
GLUD1	transfac_pro__M08803	CREM (directAnnotation).
GLUD1	transfac_pro__M07981	ATF3 (inferredBy_Orthology).
GLUD1	cisbp__M04023	CREB1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
GLUD1	"Aluminum chloride"	DB11081	small molecule
GLUD1	"Glutamic acid"	DB00142	small molecule
GLUD1	"Guanosine-5'-Triphosphate"	DB04137	small molecule
GLUD1	"Hexachlorophene"	DB00756	small molecule
GLUD1	"NADH"	DB00157	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."