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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: GLTP

Summary for GLTP

Gene information	Gene symbol	GLTP
	Ensembl ID	ENSG00000139433
	Entrez ID	51228
	Gene name	glycolipid transfer protein
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q9NZD2

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Dataset with differentially expressed gene: GLTP

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.366175	1.94e-12
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.592496	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.329395	2.01e-17
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.289278	2.07e-28
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.266707	0.00e+00

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Expression of GLTP in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GLTP

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GLTP

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GLTP	hsa-miR-4326	98.9697	NM_016433
GLTP	hsa-miR-541-5p	92.1785	NM_016433
GLTP	hsa-miR-216a-3p	91.5594	NM_016433
GLTP	hsa-miR-1252-5p	91.2753	NM_016433
GLTP	hsa-miR-544a	90.7893	NM_016433
GLTP	hsa-miR-128-3p	89.1083	NM_016433
GLTP	hsa-miR-7152-3p	88.2253	NM_016433
GLTP	hsa-miR-6839-3p	87.4659	NM_016433
GLTP	hsa-miR-9985	86.9154	NM_016433
GLTP	hsa-miR-27b-3p	86.9154	NM_016433
GLTP	hsa-miR-27a-3p	86.9154	NM_016433
GLTP	hsa-miR-548c-3p	86.8474	NM_016433
GLTP	hsa-miR-3714	86.7503	NM_016433
GLTP	hsa-miR-3681-3p	86.4197	NM_016433
GLTP	hsa-miR-4524a-3p	85.603	NM_016433
GLTP	hsa-miR-3158-5p	85.5768	NM_016433
GLTP	hsa-miR-3529-3p	84.9654	NM_016433
GLTP	hsa-miR-9902	84.129	NM_016433
GLTP	hsa-miR-298	82.2233	NM_016433
GLTP	hsa-miR-8087	80.6242	NM_016433

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Motifs and transcription factors (TFs) regulating GLTP

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GLTP	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
GLTP	cisbp__M00968	MTF2 (directAnnotation).
GLTP	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
GLTP	metacluster_151.2	ZNF23 (directAnnotation).
GLTP	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
GLTP	hdpi__FLI1	FLI1 (directAnnotation).
GLTP	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
GLTP	metacluster_81.7	CREB1 (directAnnotation).
GLTP	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
GLTP	taipale_tf_pairs__GCM2_ELK1_NNRNGGGCGGAARTN_CAP	ELK1; GCM2 (directAnnotation).
GLTP	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
GLTP	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
GLTP	"Capric acid"	DB03600	small molecule
GLTP	"Lactose"	DB04465	small molecule
GLTP	"Lauric acid"	DB03017	small molecule
GLTP	"Sphingosine"	DB03203	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."