Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: GLO1

Summary for GLO1

Gene information	Gene symbol	GLO1
	Ensembl ID	ENSG00000124767
	Entrez ID	2739
	Gene name	glyoxalase I
	Synonyms	GLOD1
	Gene type	protein_coding
	UniProtAcc	Q04760

Top

Dataset with differentially expressed gene: GLO1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.285935	6.36e-14
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.316004	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.320073	0.00e+00
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	pre	Malignant cells	-0.341348	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.445466	1.16e-36
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.457227	1.71e-21
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.459257	5.60e-30
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.383848	2.87e-16
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.412855	1.21e-20
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.272239	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.267478	0.00e+00

Top

Expression of GLO1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to GLO1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating GLO1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GLO1	hsa-miR-12119	93.4041	NM_006708
GLO1	hsa-miR-6751-3p	91.6919	NM_006708
GLO1	hsa-miR-1199-5p	91.6919	NM_006708
GLO1	hsa-miR-7515	91.6754	NM_006708
GLO1	hsa-miR-1252-3p	91.2404	NM_006708
GLO1	hsa-miR-6865-5p	90.583	NM_006708
GLO1	hsa-miR-6815-5p	90.583	NM_006708
GLO1	hsa-miR-561-5p	89.9022	NM_006708
GLO1	hsa-miR-4799-5p	89.7808	NM_006708
GLO1	hsa-miR-6800-5p	89.0974	NM_006708
GLO1	hsa-miR-10522-5p	88.2015	NM_006708
GLO1	hsa-miR-539-5p	86.9092	NM_006708
GLO1	hsa-miR-103a-2-5p	85.612	NM_006708
GLO1	hsa-miR-103a-1-5p	85.612	NM_006708
GLO1	hsa-miR-374a-5p	85.3952	NM_006708
GLO1	hsa-miR-1269a	84.7287	NM_006708
GLO1	hsa-miR-1269b	84.7287	NM_006708
GLO1	hsa-miR-944	84.0769	NM_006708
GLO1	hsa-miR-5007-5p	83.6812	NM_006708
GLO1	hsa-miR-6864-5p	83.19	NM_006708
GLO1	hsa-miR-4740-5p	82.352	NM_006708
GLO1	hsa-miR-374b-5p	82.3359	NM_006708
GLO1	hsa-miR-4540	80.5937	NM_006708

Page: 1

Top

Motifs and transcription factors (TFs) regulating GLO1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GLO1	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
GLO1	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
GLO1	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
GLO1	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
GLO1	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
GLO1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
GLO1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
GLO1	jaspar__MA0748.2	YY2 (directAnnotation).
GLO1	taipale_tf_pairs__E2F1_NHLH1_SGCGCCNNNNNNNNNNNNCAGCTGNN_CAP_repr	E2F1; NHLH1 (directAnnotation).
GLO1	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
GLO1	metacluster_81.7	CREB1 (directAnnotation).
GLO1	kznf__ZNF441_Imbeault2017_OM_RCADE	ZNF441 (directAnnotation).
GLO1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
GLO1	"Glutathione"	DB00143	small molecule
GLO1	"Indomethacin"	DB00328	small molecule
GLO1	"Mercaptoethanol"	DB03345	small molecule
GLO1	"methyl 4-(2,3-dihydroxy-5-methylphenoxy)-2-hydroxy-6-methylbenzoate"	DB08179	small molecule
GLO1	"S-(N-hydroxy-N-iodophenylcarbamoyl)glutathione"	DB03330	small molecule
GLO1	"S-benzylglutathione"	DB03602	small molecule
GLO1	"S-Hexylglutathione"	DB04132	small molecule
GLO1	"S-P-Nitrobenzyloxycarbonylglutathione"	DB03130	small molecule

Page: 1

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."