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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: GLIS3

Summary for GLIS3

Gene information	Gene symbol	GLIS3
	Ensembl ID	ENSG00000107249
	Entrez ID	169792
	Gene name	GLIS family zinc finger 3
	Synonyms	MGC33662\|ZNF515
	Gene type	protein_coding
	UniProtAcc	Q8NEA6

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Dataset with differentially expressed gene: GLIS3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.99779	2.65e-05
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.310586	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.407662	0.00e+00

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Expression of GLIS3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GLIS3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GLIS3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GLIS3	hsa-miR-302e	99.8388	NM_001042413
GLIS3	hsa-miR-5688	99.8285	NM_001042413
GLIS3	hsa-miR-495-3p	99.8214	NM_001042413
GLIS3	hsa-miR-372-3p	99.7951	NM_001042413
GLIS3	hsa-miR-520b-3p	99.7951	NM_001042413
GLIS3	hsa-miR-373-3p	99.7951	NM_001042413
GLIS3	hsa-miR-302d-3p	99.7951	NM_001042413
GLIS3	hsa-miR-520c-3p	99.7951	NM_001042413
GLIS3	hsa-miR-302c-3p	99.7951	NM_001042413
GLIS3	hsa-miR-302b-3p	99.7951	NM_001042413
GLIS3	hsa-miR-520e-3p	99.7951	NM_001042413
GLIS3	hsa-miR-520a-3p	99.7951	NM_001042413
GLIS3	hsa-miR-520d-3p	99.7951	NM_001042413
GLIS3	hsa-miR-302a-3p	99.7951	NM_001042413
GLIS3	hsa-miR-4755-5p	99.4266	NM_001042413
GLIS3	hsa-miR-548aw	99.2341	NM_152629
GLIS3	hsa-miR-5006-3p	99.1921	NM_001042413
GLIS3	hsa-miR-153-5p	98.512	NM_152629
GLIS3	hsa-miR-1468-3p	97.7754	NM_152629
GLIS3	hsa-miR-548x-5p	96.965	NM_152629
GLIS3	hsa-miR-548g-5p	96.965	NM_152629
GLIS3	hsa-miR-548aj-5p	96.965	NM_152629
GLIS3	hsa-miR-548f-5p	96.965	NM_152629
GLIS3	hsa-miR-20a-5p	96.7226	NM_001042413
GLIS3	hsa-miR-106b-5p	96.7226	NM_001042413
GLIS3	hsa-miR-526b-3p	96.7074	NM_001042413
GLIS3	hsa-miR-106a-5p	96.7074	NM_001042413
GLIS3	hsa-let-7c-3p	96.4335	NM_001042413
GLIS3	hsa-miR-17-5p	96.2087	NM_001042413
GLIS3	hsa-miR-519d-3p	96.2087	NM_001042413
GLIS3	hsa-miR-93-5p	96.2087	NM_001042413
GLIS3	hsa-miR-20b-5p	96.2087	NM_001042413
GLIS3	hsa-miR-3938	95.2966	NM_001042413
GLIS3	hsa-miR-211-5p	94.488	NM_001042413
GLIS3	hsa-miR-204-5p	94.488	NM_001042413
GLIS3	hsa-miR-548t-5p	93.5005	NM_001042413
GLIS3	hsa-miR-548az-5p	93.5005	NM_001042413
GLIS3	hsa-miR-3163	92.7332	NM_001042413
GLIS3	hsa-miR-5692a	92.7279	NM_152629
GLIS3	hsa-miR-4328	92.1053	NM_001042413
GLIS3	hsa-miR-485-5p	92.0907	NM_152629
GLIS3	hsa-miR-6884-5p	92.0907	NM_152629
GLIS3	hsa-miR-5586-5p	91.9784	NM_001042413
GLIS3	hsa-miR-5193	91.9771	NM_152629
GLIS3	hsa-miR-633	91.6801	NM_001042413
GLIS3	hsa-miR-3679-3p	91.3047	NM_152629
GLIS3	hsa-miR-498-3p	90.5723	NM_152629
GLIS3	hsa-miR-145-5p	89.6903	NM_001042413
GLIS3	hsa-miR-5195-3p	89.6903	NM_001042413
GLIS3	hsa-miR-4455	89.4347	NM_152629

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Motifs and transcription factors (TFs) regulating GLIS3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GLIS3	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
GLIS3	transfac_pro__M04950	EGR1 (directAnnotation).
GLIS3	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
GLIS3	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
GLIS3	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
GLIS3	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
GLIS3	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
GLIS3	transfac_pro__M00652	NRF1 (directAnnotation).
GLIS3	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
GLIS3	transfac_pro__M04866	HDAC2 (directAnnotation).
GLIS3	jaspar__MA1122.1	TFDP1 (directAnnotation).
GLIS3	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
GLIS3	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
GLIS3	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
GLIS3	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
GLIS3	transfac_pro__M04617	ZBTB7A (directAnnotation).
GLIS3	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
GLIS3	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
GLIS3	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
GLIS3	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
GLIS3	transfac_pro__M07387	ZBTB7A (directAnnotation).
GLIS3	transfac_pro__M07436	WT1 (directAnnotation).
GLIS3	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
GLIS3	transfac_pro__M00716	ZBTB14 (directAnnotation).
GLIS3	swissregulon__hs__CHD1	CHD1 (directAnnotation).
GLIS3	hdpi__HIP2	UBE2K (directAnnotation).
GLIS3	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
GLIS3	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
GLIS3	transfac_pro__M04893	TAF1 (directAnnotation).
GLIS3	transfac_pro__M03876	ZBTB33 (directAnnotation).
GLIS3	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
GLIS3	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
GLIS3	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
GLIS3	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
GLIS3	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
GLIS3	metacluster_135.11	NR2C2 (directAnnotation).
GLIS3	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
GLIS3	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
GLIS3	metacluster_7.13	ZFX (directAnnotation).
GLIS3	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
GLIS3	cisbp__M00968	MTF2 (directAnnotation).
GLIS3	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
GLIS3	metacluster_160.20	JUND; PRDM15 (directAnnotation).
GLIS3	cisbp__M00341	PAX6 (directAnnotation).
GLIS3	metacluster_198.3	ZFP64 (directAnnotation).
GLIS3	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
GLIS3	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
GLIS3	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
GLIS3	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
GLIS3	cisbp__M00788	ZFY (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."