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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: GLIS2

Summary for GLIS2

Gene informationGene symbol

GLIS2

Ensembl ID

ENSG00000274636

Entrez ID

84662

Gene nameGLIS family zinc finger 2
SynonymsNPHP7
Gene typeprotein_coding
UniProtAcc

Q9BZE0


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Dataset with differentially expressed gene: GLIS2

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE131984_JQ1Pal

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapyJQ1 + palbociclibNAMalignant cells0.2639291.78e-17

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Expression of GLIS2 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to GLIS2

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GLIS2

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
GLIS2hsa-miR-766-5p97.2195NM_001318918
GLIS2hsa-miR-6852-5p96.3867NM_001318918
GLIS2hsa-miR-505-5p95.8812NM_001318918
GLIS2hsa-miR-137-3p94.9346NM_001318918
GLIS2hsa-miR-449290.8385NM_001318918
GLIS2hsa-miR-7111-3p89.7374NM_001318918
GLIS2hsa-miR-130a-5p88.688NM_001318918
GLIS2hsa-miR-21-5p88.0349NM_001318918
GLIS2hsa-miR-5579-3p87.1922NM_001318918
GLIS2hsa-miR-590-5p85.1888NM_001318918
GLIS2hsa-miR-6722-3p84.7187NM_001318918
GLIS2hsa-miR-450583.9013NM_001318918
GLIS2hsa-miR-76283.6605NM_001318918
GLIS2hsa-miR-6873-5p83.348NM_001318918
GLIS2hsa-miR-449882.2823NM_001318918
GLIS2hsa-miR-6756-5p82.01NM_001318918
GLIS2hsa-miR-6766-5p81.946NM_001318918
GLIS2hsa-miR-578781.5909NM_001318918
GLIS2hsa-miR-5001-5p81.4009NM_001318918
GLIS2hsa-miR-2276-5p81.1787NM_001318918
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Motifs and transcription factors (TFs) regulating GLIS2

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
GLIS2jaspar__MA0079.5SP1 (directAnnotation).
GLIS2metacluster_153.4SOX12; SOX14; SRY (directAnnotation). SOX5 (inferredBy_Orthology).
GLIS2transfac_pro__M02896SPI1 (inferredBy_Orthology).
GLIS2metacluster_74.6HNF1A (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."