Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: GLIPR1

Summary for GLIPR1

Gene information	Gene symbol	GLIPR1
	Ensembl ID	ENSG00000139278
	Entrez ID	11010
	Gene name	GLI pathogenesis related 1
	Synonyms	GliPR\|RTVP1
	Gene type	protein_coding
	UniProtAcc	NA

Top

Dataset with differentially expressed gene: GLIPR1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.335997	2.46e-09
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD8+ T cells	0.270376	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	NK cells	0.25337	8.88e-31
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.305028	2.19e-11
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.42006	1.43e-33
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.451298	8.20e-21
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	Mono/Macro	0.301698	8.67e-41
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.360575	1.10e-05
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-1.15323	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.614796	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	0.350354	0.00e+00
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	pre	CD4+ T cells	-0.317301	9.03e-05
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.586871	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.63871	1.22e-37
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.521754	6.72e-33
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.508599	0.00e+00

Top

Expression of GLIPR1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to GLIPR1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating GLIPR1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GLIPR1	hsa-miR-183-3p	99.3361	NM_006851
GLIPR1	hsa-miR-4659b-3p	98.0157	NM_006851
GLIPR1	hsa-miR-4659a-3p	98.0157	NM_006851
GLIPR1	hsa-miR-487a-5p	95.7039	NM_006851
GLIPR1	hsa-miR-487b-5p	95.7039	NM_006851
GLIPR1	hsa-miR-6844	94.0162	NM_006851
GLIPR1	hsa-miR-4795-3p	92.8796	NM_006851
GLIPR1	hsa-miR-4307	91.0946	NM_006851
GLIPR1	hsa-miR-6815-3p	90.3109	NM_006851
GLIPR1	hsa-miR-651-3p	89.5138	NM_006851
GLIPR1	hsa-miR-3160-5p	88.2518	NM_006851
GLIPR1	hsa-miR-6830-5p	87.9739	NM_006851
GLIPR1	hsa-miR-4284	87.1737	NM_006851
GLIPR1	hsa-miR-3182	87.1707	NM_006851
GLIPR1	hsa-miR-1256	86.9776	NM_006851
GLIPR1	hsa-miR-376b-3p	86.9747	NM_006851
GLIPR1	hsa-miR-376a-3p	86.9747	NM_006851
GLIPR1	hsa-miR-3688-3p	86.3251	NM_006851
GLIPR1	hsa-miR-4423-5p	85.7591	NM_006851
GLIPR1	hsa-miR-548i	84.1973	NM_006851
GLIPR1	hsa-miR-548ab	84.1973	NM_006851
GLIPR1	hsa-miR-6806-5p	84.1104	NM_006851
GLIPR1	hsa-miR-559	82.9908	NM_006851
GLIPR1	hsa-miR-541-5p	82.7739	NM_006851
GLIPR1	hsa-miR-6124	82.4369	NM_006851
GLIPR1	hsa-miR-7159-3p	82.3083	NM_006851
GLIPR1	hsa-miR-5187-3p	82.2522	NM_006851
GLIPR1	hsa-miR-548aa	82.2375	NM_006851
GLIPR1	hsa-miR-548t-3p	82.2375	NM_006851
GLIPR1	hsa-miR-548ap-3p	82.2375	NM_006851
GLIPR1	hsa-miR-4753-3p	81.993	NM_006851
GLIPR1	hsa-miR-548ap-5p	81.778	NM_006851
GLIPR1	hsa-miR-548b-5p	81.778	NM_006851
GLIPR1	hsa-miR-548c-5p	81.778	NM_006851
GLIPR1	hsa-miR-548as-5p	81.778	NM_006851
GLIPR1	hsa-miR-548ad-5p	81.778	NM_006851
GLIPR1	hsa-miR-548aq-5p	81.778	NM_006851
GLIPR1	hsa-miR-548d-5p	81.778	NM_006851
GLIPR1	hsa-miR-548ae-5p	81.778	NM_006851
GLIPR1	hsa-miR-548h-5p	81.778	NM_006851
GLIPR1	hsa-miR-548y	81.778	NM_006851
GLIPR1	hsa-miR-548am-5p	81.778	NM_006851
GLIPR1	hsa-miR-548ay-5p	81.778	NM_006851
GLIPR1	hsa-miR-548au-5p	81.778	NM_006851
GLIPR1	hsa-miR-548ar-5p	81.778	NM_006851
GLIPR1	hsa-miR-548w	81.778	NM_006851
GLIPR1	hsa-miR-548o-5p	81.778	NM_006851
GLIPR1	hsa-miR-548bb-5p	81.778	NM_006851
GLIPR1	hsa-miR-548j-5p	81.778	NM_006851
GLIPR1	hsa-miR-548ak	81.778	NM_006851

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating GLIPR1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GLIPR1	metacluster_22.18	BACH2 (inferredBy_Orthology).
GLIPR1	metacluster_22.37	BACH1 (directAnnotation).
GLIPR1	metacluster_22.36	BACH2 (directAnnotation).
GLIPR1	metacluster_22.34	BACH2 (directAnnotation).
GLIPR1	metacluster_22.20	MAFG (directAnnotation).
GLIPR1	metacluster_22.35	MAFK (directAnnotation).
GLIPR1	metacluster_22.16	BACH2 (directAnnotation).
GLIPR1	metacluster_22.11	NFE2 (directAnnotation).
GLIPR1	metacluster_22.33	MAFK (inferredBy_Orthology).
GLIPR1	metacluster_22.32	NFE2L2 (directAnnotation).
GLIPR1	metacluster_22.39	NFE2L2 (directAnnotation).
GLIPR1	metacluster_22.21	NFE2L2 (inferredBy_Orthology).
GLIPR1	metacluster_22.17	NFE2 (directAnnotation).
GLIPR1	taipale_tf_pairs__TEAD4_SPIB_RGAATGCGGAAGTN_CAP_1	SPIB; TEAD4 (directAnnotation).
GLIPR1	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
GLIPR1	transfac_pro__M05706	ZNF20 (directAnnotation).
GLIPR1	taipale_tf_pairs__ETV2_GSC2_RSCGGAANNNNNGGATTA_CAP_repr	ETV2; GSC2 (directAnnotation).
GLIPR1	taipale_tf_pairs__ETV2_PITX1_RSCGGAANNNNNGGMTTAN_CAP	ETV2; PITX1 (directAnnotation).
GLIPR1	taipale_tf_pairs__FOXJ2_ELF1_RMAGAAAACCGAANN_CAP_repr	ELF1; FOXJ2 (directAnnotation).
GLIPR1	taipale_tf_pairs__FOXO1_ELF1_NNGAAAACCGAANM_CAP	ELF1; FOXO1 (directAnnotation).
GLIPR1	transfac_pro__M05910	ZNF335 (directAnnotation).
GLIPR1	taipale_tf_pairs__HOXD12_ELK3_RSCGGAAGTAATAAAN_CAP	ELK3; HOXD12 (directAnnotation).
GLIPR1	transfac_pro__M05697	ZNF235 (directAnnotation).
GLIPR1	cisbp__M00767	ZSCAN10 (inferredBy_Orthology).
GLIPR1	transfac_pro__M06723	ZNF492 (directAnnotation).
GLIPR1	tfdimers__MD00217	LTF; MZF1 (directAnnotation).
GLIPR1	taipale_cyt_meth__TLX3_NAATTGNNNNNNNNNNCAATTN_FL_repr	TLX3 (directAnnotation).
GLIPR1	transfac_public__M00051	NFKB1 (directAnnotation).
GLIPR1	jaspar__MA1956.1	FOXO1 (directAnnotation).
GLIPR1	jaspar__MA1954.1	FOXO1 (directAnnotation).
GLIPR1	jaspar__MA1946.1	FOXI1 (directAnnotation).
GLIPR1	tfdimers__MD00221	FOXG1; FOXO1; GABPA (directAnnotation).
GLIPR1	jaspar__MA1955.1	FOXO1 (directAnnotation).
GLIPR1	metacluster_132.4	MEF2B; MEF2B; MEF2B; MEF2B; MEF2C; MEF2C; MEF2D; MEF2D; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF (directAnnotation). SRF; SRF; SRF; SRF (inferredBy_Orthology).
GLIPR1	metacluster_80.6	ZIC4 (directAnnotation).
GLIPR1	metacluster_80.4	ZIC3 (directAnnotation).
GLIPR1	kznf__ZNF445_Imbeault2017_OM_MEME	ZNF445 (directAnnotation).
GLIPR1	transfac_pro__M05699	ZNF816 (directAnnotation).
GLIPR1	hocomoco__GMEB2_HUMAN.H11MO.0.D	GMEB2 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
GLIPR1	"SOT-107"	DB05337	biotech

Page: 1

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."