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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: GKAP1

Summary for GKAP1

Gene information	Gene symbol	GKAP1
	Ensembl ID	ENSG00000165113
	Entrez ID	80318
	Gene name	G kinase anchoring protein 1
	Synonyms	FKSG21\|GKAP42
	Gene type	protein_coding
	UniProtAcc	Q5VSY0

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Dataset with differentially expressed gene: GKAP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.584366	0.00e+00

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Expression of GKAP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GKAP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GKAP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GKAP1	hsa-miR-548aq-3p	98.1812	NM_001135953
GKAP1	hsa-miR-548j-3p	98.1812	NM_001135953
GKAP1	hsa-miR-548am-3p	98.1812	NM_001135953
GKAP1	hsa-miR-548ae-3p	98.1812	NM_001135953
GKAP1	hsa-miR-548ah-3p	98.1812	NM_001135953
GKAP1	hsa-miR-548aj-3p	98.1812	NM_001135953
GKAP1	hsa-miR-548x-3p	98.1812	NM_001135953
GKAP1	hsa-miR-548av-3p	96.5733	NM_001135953
GKAP1	hsa-miR-6077	94.6207	NM_001135953
GKAP1	hsa-miR-4775	94.1415	NM_001135953
GKAP1	hsa-miR-4310	93.9732	NM_001135953
GKAP1	hsa-miR-7157-5p	93.9732	NM_001135953
GKAP1	hsa-miR-7-5p	91.4714	NM_001135953
GKAP1	hsa-miR-548ah-5p	90.5342	NM_001135953
GKAP1	hsa-miR-3609	90.5342	NM_001135953
GKAP1	hsa-miR-6071	89.2262	NM_001135953
GKAP1	hsa-miR-3162-5p	88.7229	NM_001135953
GKAP1	hsa-miR-3136-5p	87.8467	NM_001135953
GKAP1	hsa-miR-4439	87.8467	NM_001135953
GKAP1	hsa-miR-548bc	87.4535	NM_001135953
GKAP1	hsa-miR-548az-3p	87.4535	NM_001135953
GKAP1	hsa-miR-548e-3p	87.4535	NM_001135953
GKAP1	hsa-miR-548f-3p	87.4535	NM_001135953
GKAP1	hsa-miR-548a-3p	87.4535	NM_001135953
GKAP1	hsa-miR-548ar-3p	87.4535	NM_001135953
GKAP1	hsa-miR-590-3p	86.9187	NM_001135953
GKAP1	hsa-miR-6807-3p	83.7688	NM_001135953
GKAP1	hsa-miR-217-5p	83.7688	NM_001135953
GKAP1	hsa-miR-3692-5p	81.0442	NM_001135953

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Motifs and transcription factors (TFs) regulating GKAP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GKAP1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
GKAP1	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
GKAP1	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
GKAP1	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
GKAP1	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
GKAP1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
GKAP1	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
GKAP1	metacluster_3.14	WT1; WT1 (directAnnotation).
GKAP1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
GKAP1	cisbp__M07938	E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."