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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: GK

Summary for GK

Gene information	Gene symbol	GK
	Ensembl ID	ENSG00000198814
	Entrez ID	2710
	Gene name	glycerol kinase
	Synonyms	GK1\|GKD
	Gene type	protein_coding
	UniProtAcc	P32189

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Dataset with differentially expressed gene: GK

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	2.63217	2.36e-03
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	0.469824	6.12e-11
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	0.347452	2.64e-02
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.569256	0.00e+00

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Expression of GK in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GK

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GK

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GK	hsa-miR-3163	95.857	NM_000167
GK	hsa-miR-4528	95.1623	NM_000167
GK	hsa-miR-4659a-3p	92.2602	NM_000167
GK	hsa-miR-4659b-3p	92.2602	NM_000167
GK	hsa-miR-4501	88.5543	NM_000167
GK	hsa-miR-95-5p	88.2411	NM_000167
GK	hsa-miR-9983-3p	87.8181	NM_000167
GK	hsa-miR-3973	87.3798	NM_000167
GK	hsa-miR-4795-3p	86.7382	NM_000167
GK	hsa-miR-12136	86.6477	NM_000167
GK	hsa-miR-4276	86.2545	NM_000167
GK	hsa-miR-676-5p	85.9409	NM_000167
GK	hsa-miR-494-3p	85.198	NM_000167
GK	hsa-miR-29b-2-5p	84.789	NM_000167
GK	hsa-miR-182-5p	84.6814	NM_000167
GK	hsa-miR-323a-5p	83.6646	NM_000167
GK	hsa-miR-3668	83.4613	NM_000167
GK	hsa-miR-186-3p	82.4952	NM_000167
GK	hsa-miR-32-3p	82.2584	NM_000167
GK	hsa-miR-6818-5p	81.7694	NM_000167
GK	hsa-miR-3177-5p	80.3216	NM_000167

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Motifs and transcription factors (TFs) regulating GK

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GK	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
GK	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
GK	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
GK	transfac_pro__M07387	ZBTB7A (directAnnotation).
GK	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
GK	transfac_pro__M00716	ZBTB14 (directAnnotation).
GK	swissregulon__hs__CHD1	CHD1 (directAnnotation).
GK	hdpi__HIP2	UBE2K (directAnnotation).
GK	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
GK	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
GK	transfac_pro__M04893	TAF1 (directAnnotation).
GK	transfac_pro__M03876	ZBTB33 (directAnnotation).
GK	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
GK	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
GK	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
GK	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
GK	metacluster_135.11	NR2C2 (directAnnotation).
GK	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
GK	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
GK	metacluster_7.13	ZFX (directAnnotation).
GK	cisbp__M00968	MTF2 (directAnnotation).
GK	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
GK	cisbp__M00341	PAX6 (directAnnotation).
GK	metacluster_198.3	ZFP64 (directAnnotation).
GK	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
GK	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
GK	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
GK	cisbp__M00788	ZFY (inferredBy_Orthology).
GK	metacluster_175.1	ZNF283 (directAnnotation).
GK	hdpi__ZNF304	ZNF304 (directAnnotation).
GK	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
GK	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
GK	metacluster_151.2	ZNF23 (directAnnotation).
GK	transfac_pro__M06586	ZNF479 (directAnnotation).
GK	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
GK	transfac_pro__M06556	ZNF383 (directAnnotation).
GK	metacluster_155.21	ZNF454; ZNF454 (directAnnotation).
GK	metacluster_2.9	IRF2; IRF2; IRF2; PRDM1; PRDM1 (directAnnotation). PRDM1 (inferredBy_Orthology).
GK	metacluster_57.3	ARNT; ATF3; ATF3; ATF3; ATF3; BHLHE40; BHLHE40; BHLHE40; BHLHE41; BHLHE41; BHLHE41; MITF; MITF; MITF; MLX; MLXIPL; SREBF1; SREBF1; SREBF1; SREBF1; SREBF2; SREBF2; SREBF2; TFE3; TFEC; USF1; USF1; USF1; USF1; USF1; USF1; USF1; USF1; USF1; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; ZNF507 (directAnnotation). ARNTL; BHLHE40; BHLHE40; BHLHE41; HELT; HES1; HES2; HES3; HES5; HES6; HES7; HEY1; HEY2; HEYL; MLX; MLX; SREBF1; SREBF2; TFE3; USF1; USF1; USF2; USF2 (inferredBy_Orthology).
GK	homer__GGAAATTCCC_NFkB-p65-Rel	RELA (inferredBy_Orthology).
GK	taipale_tf_pairs__FLI1_FOXI1_RCCGGATGTTKWY_CAP	FLI1; FOXI1 (directAnnotation).
GK	kznf__ZNF77_Imbeault2017_OM_MEME	ZNF77 (directAnnotation).
GK	hocomoco__ZN713_HUMAN.H11MO.0.D	ZNF713 (directAnnotation).
GK	transfac_pro__M06012	ZNF586 (directAnnotation).
GK	tfdimers__MD00143	IKZF1; MZF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."