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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: GIT1

Summary for GIT1

Gene information	Gene symbol	GIT1
	Ensembl ID	ENSG00000108262
	Entrez ID	28964
	Gene name	GIT ArfGAP 1
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q9Y2X7

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Dataset with differentially expressed gene: GIT1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.279672	3.69e-38

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Expression of GIT1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GIT1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GIT1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GIT1	hsa-miR-6756-5p	91.2356	NM_001085454
GIT1	hsa-miR-6766-5p	91.2356	NM_001085454
GIT1	hsa-miR-4447	91.0737	NM_001085454
GIT1	hsa-miR-760	90.8495	NM_001085454
GIT1	hsa-miR-6797-5p	90.6305	NM_001085454
GIT1	hsa-miR-1249-5p	90.6305	NM_001085454
GIT1	hsa-miR-149-5p	88.2921	NM_001085454
GIT1	hsa-miR-608	87.5355	NM_001085454
GIT1	hsa-miR-4651	87.5355	NM_001085454
GIT1	hsa-miR-140-3p	87.2814	NM_001085454
GIT1	hsa-miR-4472	87.1717	NM_001085454
GIT1	hsa-miR-4758-3p	86.9612	NM_001085454
GIT1	hsa-miR-122-5p	86.4402	NM_001085454
GIT1	hsa-miR-92a-2-5p	85.9144	NM_001085454
GIT1	hsa-miR-892b	85.4989	NM_001085454
GIT1	hsa-miR-6780b-5p	84.899	NM_001085454
GIT1	hsa-miR-4725-3p	84.899	NM_001085454
GIT1	hsa-miR-1-3p	84.7436	NM_001085454
GIT1	hsa-miR-206	84.7436	NM_001085454
GIT1	hsa-miR-3665	84.6443	NM_001085454
GIT1	hsa-miR-1913	83.9781	NM_001085454
GIT1	hsa-miR-491-5p	83.2844	NM_001085454
GIT1	hsa-miR-199b-5p	82.9789	NM_001085454
GIT1	hsa-miR-199a-5p	82.9789	NM_001085454
GIT1	hsa-miR-4450	80.4449	NM_001085454
GIT1	hsa-miR-4271	80.2278	NM_001085454
GIT1	hsa-miR-6858-3p	80.0987	NM_001085454
GIT1	hsa-miR-4492	80.0712	NM_001085454

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Motifs and transcription factors (TFs) regulating GIT1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GIT1	jaspar__MA1483.2	ELF2 (directAnnotation).
GIT1	metacluster_151.2	ZNF23 (directAnnotation).
GIT1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
GIT1	transfac_pro__M06071	ZNF814 (directAnnotation).
GIT1	jaspar__MA0079.5	SP1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."