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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: GIMAP1

Summary for GIMAP1

Gene information	Gene symbol	GIMAP1
	Ensembl ID	ENSG00000213203
	Entrez ID	170575
	Gene name	GTPase, IMAP family member 1
	Synonyms	HIMAP1\|IAN2\|IMAP1\|IMAP38
	Gene type	protein_coding
	UniProtAcc	Q8WWP7

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Dataset with differentially expressed gene: GIMAP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD8+ T cells	0.33459	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	0.404749	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD8+ T cells	-0.470858	6.05e-10
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	NK cells	-0.45124	1.95e-05

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Expression of GIMAP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GIMAP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GIMAP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GIMAP1	hsa-miR-6867-5p	99.9734	NM_130759
GIMAP1	hsa-miR-1275	95.1885	NM_130759
GIMAP1	hsa-miR-6508-5p	95.187	NM_130759
GIMAP1	hsa-miR-8067	94.8045	NM_130759
GIMAP1	hsa-miR-625-5p	92.251	NM_130759
GIMAP1	hsa-miR-1537-5p	92.1277	NM_130759
GIMAP1	hsa-miR-4665-5p	89.9113	NM_130759
GIMAP1	hsa-miR-6736-3p	88.8936	NM_130759
GIMAP1	hsa-miR-4252	87.9006	NM_130759
GIMAP1	hsa-miR-4685-5p	84.4939	NM_130759
GIMAP1	hsa-miR-6837-5p	84.4939	NM_130759
GIMAP1	hsa-miR-6882-5p	83.4174	NM_130759
GIMAP1	hsa-miR-5696	82.3009	NM_130759
GIMAP1	hsa-miR-5582-3p	81.7268	NM_130759

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Motifs and transcription factors (TFs) regulating GIMAP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GIMAP1	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
GIMAP1	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
GIMAP1	metacluster_166.5	ERG; ETV2; FLI1 (directAnnotation).
GIMAP1	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
GIMAP1	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
GIMAP1	taipale_tf_pairs__TEAD4_HOXA2_RCATTCNNNNNNCATTA_CAP	HOXA2; TEAD4 (directAnnotation).
GIMAP1	jaspar__MA1725.1	ZNF189 (directAnnotation).
GIMAP1	tfdimers__MD00187	GATA1; GATA2; GATA3; GATA4; GATA5; GATA6 (directAnnotation).
GIMAP1	taipale_cyt_meth__HSF5_NRCGTTCTAGAAYGYN_eDBD_repr	HSF5 (directAnnotation).
GIMAP1	transfac_pro__M06173	ZNF85 (directAnnotation).
GIMAP1	taipale_tf_pairs__TEAD4_HOXA3_RCATTCNNNNNNCATTA_CAP	HOXA3; TEAD4 (directAnnotation).
GIMAP1	taipale_tf_pairs__FOXJ2_ELF1_RMAGAAAACCGAANN_CAP_repr	ELF1; FOXJ2 (directAnnotation).
GIMAP1	metacluster_108.2	ZNF286A (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."