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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: GID8

Summary for GID8

Gene information	Gene symbol	GID8
	Ensembl ID	ENSG00000101193
	Entrez ID	54994
	Gene name	GID complex subunit 8 homolog
	Synonyms	bA305P22.1\|C20orf11\|FLJ20602\|TWA1
	Gene type	protein_coding
	UniProtAcc	Q9NWU2

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Dataset with differentially expressed gene: GID8

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.485351	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.370913	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.35852	3.59e-08
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.318365	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.307737	0.00e+00

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Expression of GID8 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GID8

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GID8

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GID8	hsa-miR-3065-3p	98.4741	NM_017896
GID8	hsa-miR-3124-3p	96.3629	NM_017896
GID8	hsa-miR-4446-5p	96.0619	NM_017896
GID8	hsa-miR-4684-5p	95.6472	NM_017896
GID8	hsa-miR-190a-3p	94.9935	NM_017896
GID8	hsa-miR-6883-3p	94.6823	NM_017896
GID8	hsa-miR-346	91.7427	NM_017896
GID8	hsa-miR-3613-3p	90.9085	NM_017896
GID8	hsa-miR-3148	90.0638	NM_017896
GID8	hsa-miR-4311	89.5238	NM_017896
GID8	hsa-miR-4251	88.765	NM_017896
GID8	hsa-miR-29a-3p	88.3924	NM_017896
GID8	hsa-miR-29c-3p	88.3924	NM_017896
GID8	hsa-miR-29b-3p	88.3924	NM_017896
GID8	hsa-miR-509-5p	88.279	NM_017896
GID8	hsa-miR-509-3-5p	88.279	NM_017896
GID8	hsa-miR-202-5p	88.2161	NM_017896
GID8	hsa-miR-524-5p	87.6284	NM_017896
GID8	hsa-miR-520d-5p	87.6284	NM_017896
GID8	hsa-miR-640	86.4346	NM_017896
GID8	hsa-miR-1305	85.5176	NM_017896
GID8	hsa-miR-4418	84.77	NM_017896
GID8	hsa-miR-6128	83.7717	NM_017896
GID8	hsa-miR-454-5p	83.7684	NM_017896
GID8	hsa-miR-218-2-3p	83.4577	NM_017896
GID8	hsa-miR-4773	83.2814	NM_017896
GID8	hsa-miR-4700-3p	82.8005	NM_017896
GID8	hsa-miR-6760-5p	82.4777	NM_017896
GID8	hsa-miR-1277-5p	82.3458	NM_017896

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Motifs and transcription factors (TFs) regulating GID8

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GID8	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
GID8	cisbp__M08198	ELF1 (directAnnotation).
GID8	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
GID8	hdpi__FLI1	FLI1 (directAnnotation).
GID8	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."