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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: GHR

Summary for GHR

Gene information	Gene symbol	GHR
	Ensembl ID	ENSG00000112964
	Entrez ID	2690
	Gene name	growth hormone receptor
	Synonyms	GHBP
	Gene type	protein_coding
	UniProtAcc	P10912

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Dataset with differentially expressed gene: GHR

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.285809	1.40e-45

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Expression of GHR in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GHR

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GHR

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GHR	hsa-miR-3529-3p	95.1478	NM_001242402
GHR	hsa-miR-15a-5p	93.2982	NM_001242462
GHR	hsa-miR-16-5p	93.2982	NM_001242462
GHR	hsa-miR-15b-5p	93.2982	NM_001242462
GHR	hsa-miR-195-5p	93.2982	NM_001242462
GHR	hsa-miR-202-3p	92.9369	NM_001242462
GHR	hsa-miR-6838-5p	92.3559	NM_001242462
GHR	hsa-miR-561-3p	92.2439	NM_001242402
GHR	hsa-miR-424-5p	92.2073	NM_001242462
GHR	hsa-miR-497-5p	92.2073	NM_001242462
GHR	hsa-miR-142-3p	91.885	NM_001242402
GHR	hsa-miR-3163	91.7373	NM_001242462
GHR	hsa-miR-4477a	91.6372	NM_001242462
GHR	hsa-miR-4524b-5p	91.0229	NM_001242462
GHR	hsa-miR-4524a-5p	91.0229	NM_001242462
GHR	hsa-miR-153-5p	90.3412	NM_001242402
GHR	hsa-miR-624-5p	90.1882	NM_001242462
GHR	hsa-miR-196a-1-3p	88.5247	NM_001242402
GHR	hsa-miR-7162-5p	85.6137	NM_001242462
GHR	hsa-miR-516a-3p	85.6137	NM_001242462
GHR	hsa-miR-516b-3p	85.6137	NM_001242462
GHR	hsa-miR-3926	85.3841	NM_001242402
GHR	hsa-miR-335-3p	85.0118	NM_001242462
GHR	hsa-miR-4424	84.516	NM_001242462
GHR	hsa-miR-3658	84.3999	NM_001242462
GHR	hsa-miR-873-3p	84.3413	NM_001242402
GHR	hsa-miR-3912-5p	83.6511	NM_001242462
GHR	hsa-miR-1252-5p	83.6382	NM_001242402
GHR	hsa-miR-622	82.874	NM_001242462
GHR	hsa-miR-6728-3p	82.8227	NM_001242462
GHR	hsa-miR-4698	82.6918	NM_001242462
GHR	hsa-miR-6852-3p	82.3351	NM_001242462
GHR	hsa-miR-1256	81.4548	NM_001242462
GHR	hsa-miR-4678	80.9673	NM_001242462
GHR	hsa-miR-103b	80.924	NM_001242462
GHR	hsa-miR-651-5p	80.8258	NM_001242402
GHR	hsa-miR-149-5p	80.704	NM_001242462
GHR	hsa-miR-3945	80.3072	NM_001242462
GHR	hsa-miR-3613-3p	80.1933	NM_001242402

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Motifs and transcription factors (TFs) regulating GHR

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GHR	cisbp__M02645	ETS1 (directAnnotation).
GHR	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
GHR	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
GHR	taipale_cyt_meth__ZBTB2_NTTTMCGGTWAN_eDBD	ZBTB2 (directAnnotation).
GHR	metacluster_198.7	AHR; ZBTB14; ZBTB14; ZBTB14 (directAnnotation).
GHR	taipale_tf_pairs__ERF_HES7_NCCGGAANNNNNNCACGYGNN_CAP_repr	ERF; HES7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
GHR	"Lonapegsomatropin"	DB16220	biotech
GHR	"Pegvisomant"	DB00082	biotech
GHR	"Somapacitan"	DB15093	biotech
GHR	"Somatotropin"	DB00052	biotech
GHR	"Somatrem"	DB09098	biotech

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."