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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: GGA2

Summary for GGA2

Gene information	Gene symbol	GGA2
	Ensembl ID	ENSG00000103365
	Entrez ID	23062
	Gene name	golgi associated, gamma adaptin ear containing, ARF binding protein 2
	Synonyms	KIAA1080\|VEAR
	Gene type	protein_coding
	UniProtAcc	Q9UJY4

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Dataset with differentially expressed gene: GGA2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.27785	1.70e-40
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.287605	3.63e-12
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.316399	0.00e+00

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Expression of GGA2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GGA2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GGA2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GGA2	hsa-miR-8485	99.9973	NM_015044
GGA2	hsa-miR-6077	98.9197	NM_015044
GGA2	hsa-miR-124-3p	97.7088	NM_015044
GGA2	hsa-miR-506-3p	97.1498	NM_015044
GGA2	hsa-miR-5582-5p	94.991	NM_015044
GGA2	hsa-miR-1827	94.7933	NM_015044
GGA2	hsa-miR-3158-5p	93.3881	NM_015044
GGA2	hsa-miR-4506	93.1488	NM_015044
GGA2	hsa-miR-7-5p	88.6715	NM_015044
GGA2	hsa-miR-3154	88.564	NM_015044
GGA2	hsa-miR-4284	86.968	NM_015044
GGA2	hsa-miR-661	86.2753	NM_015044
GGA2	hsa-miR-100-3p	85.2061	NM_015044
GGA2	hsa-miR-5089-5p	85.1979	NM_015044
GGA2	hsa-miR-4319	84.5933	NM_015044
GGA2	hsa-miR-4282	83.2875	NM_015044
GGA2	hsa-miR-410-5p	81.7722	NM_015044
GGA2	hsa-miR-323b-5p	81.7722	NM_015044
GGA2	hsa-miR-494-5p	81.7722	NM_015044
GGA2	hsa-miR-1184	81.559	NM_015044
GGA2	hsa-miR-125b-5p	81.0345	NM_015044
GGA2	hsa-miR-125a-5p	81.0345	NM_015044

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Motifs and transcription factors (TFs) regulating GGA2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GGA2	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
GGA2	kznf__CTCF_Rhee2011.2_ChIP-exo	CTCF (directAnnotation).
GGA2	metacluster_137.2	ATF3; BACH2; BATF; BATF; BATF; BATF; BATF3; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSB; FOSB; FOSB; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; INSM2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMARCC1 (directAnnotation). ATF3; ATF3; BATF; FOS; FOSB; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUND; JUND; JUND; JUND (inferredBy_Orthology).
GGA2	transfac_pro__M06408	ZSCAN30 (directAnnotation).
GGA2	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
GGA2	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
GGA2	jaspar__MA1721.1	ZNF93 (directAnnotation).
GGA2	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
GGA2	transfac_pro__M01973	PLAG1 (directAnnotation).
GGA2	metacluster_143.13	ZBTB7A (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."