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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: GEM

Summary for GEM

Gene information	Gene symbol	GEM
	Ensembl ID	ENSG00000164949
	Entrez ID	2669
	Gene name	GTP binding protein overexpressed in skeletal muscle
	Synonyms	KIR
	Gene type	protein_coding
	UniProtAcc	P55040

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Dataset with differentially expressed gene: GEM

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.830984	1.71e-05
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	-0.470512	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.759298	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.645478	4.49e-25

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Expression of GEM in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GEM

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GEM

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GEM	hsa-miR-5692a	99.752	NM_005261
GEM	hsa-miR-641	97.2728	NM_181702
GEM	hsa-miR-3617-5p	97.2728	NM_181702
GEM	hsa-miR-507	95.8075	NM_181702
GEM	hsa-miR-450b-5p	95.0696	NM_181702
GEM	hsa-miR-522-3p	94.5298	NM_181702
GEM	hsa-miR-224-3p	94.5298	NM_181702
GEM	hsa-miR-557	93.9687	NM_181702
GEM	hsa-miR-3121-3p	93.5186	NM_005261
GEM	hsa-miR-1468-3p	93.4453	NM_181702
GEM	hsa-miR-3658	93.4051	NM_005261
GEM	hsa-miR-3671	93.3003	NM_181702
GEM	hsa-miR-654-5p	92.8992	NM_181702
GEM	hsa-miR-4307	92.4737	NM_181702
GEM	hsa-miR-607	92.178	NM_181702
GEM	hsa-miR-3662	91.6429	NM_005261
GEM	hsa-miR-548aw	91.277	NM_181702
GEM	hsa-miR-541-3p	90.9153	NM_181702
GEM	hsa-miR-3680-3p	90.7473	NM_181702
GEM	hsa-miR-10397-3p	90.4222	NM_005261
GEM	hsa-miR-6878-3p	88.9854	NM_181702
GEM	hsa-miR-4475	88.6842	NM_181702
GEM	hsa-miR-4668-5p	88.1664	NM_181702
GEM	hsa-miR-29a-5p	87.7789	NM_181702
GEM	hsa-miR-9985	87.7559	NM_005261
GEM	hsa-miR-27b-3p	87.7559	NM_005261
GEM	hsa-miR-27a-3p	87.7559	NM_005261
GEM	hsa-miR-4477a	87.6071	NM_181702
GEM	hsa-miR-448	87.0615	NM_181702
GEM	hsa-miR-4662a-3p	86.0638	NM_005261
GEM	hsa-miR-8055	85.5612	NM_005261
GEM	hsa-miR-200c-3p	84.8115	NM_005261
GEM	hsa-miR-429	84.8115	NM_005261
GEM	hsa-miR-200b-3p	84.8115	NM_005261
GEM	hsa-miR-3679-3p	83.8626	NM_181702
GEM	hsa-miR-4694-3p	82.6221	NM_005261
GEM	hsa-miR-2278	82.1698	NM_181702
GEM	hsa-miR-4452	82.146	NM_181702
GEM	hsa-miR-128-3p	81.096	NM_005261
GEM	hsa-miR-216a-3p	81.096	NM_005261
GEM	hsa-miR-1277-5p	80.8478	NM_005261

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Motifs and transcription factors (TFs) regulating GEM

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GEM	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
GEM	cisbp__M00968	MTF2 (directAnnotation).
GEM	metacluster_160.20	JUND; PRDM15 (directAnnotation).
GEM	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
GEM	transfac_pro__M05815	ZNF613 (directAnnotation).
GEM	metacluster_2.9	IRF2; IRF2; IRF2; PRDM1; PRDM1 (directAnnotation). PRDM1 (inferredBy_Orthology).
GEM	transfac_pro__M06557	ZNF418 (directAnnotation).
GEM	tfdimers__MD00465	CRX; IKZF1 (directAnnotation).
GEM	transfac_pro__M01861	ATF1 (directAnnotation).
GEM	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
GEM	dbtfbs__GMEB2_HepG2_ENCSR745VSQ_merged_N1	GMEB2 (directAnnotation).
GEM	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
GEM	hocomoco__GMEB2_HUMAN.H11MO.0.D	GMEB2 (directAnnotation).
GEM	metacluster_111.5	E4F1; E4F1 (directAnnotation).
GEM	metacluster_148.1	ATF2; ATF2; ATF3; ATF3; ATF3; ATF3; ATF4; ATF4; ATF6; ATF6; ATF6B; ATF7; BATF3; BATF3; CREB1; CREB1; CREB1; CREB3; CREB3; CREB5; CREB5; CREB5; CREM; CREM; FOS; FOS; FOSB; FOSB; FOSB; FOSL1; JDP2; JDP2; JUN; JUN; JUN; JUNB; JUND; MAF; MAF; MAFA; MAFA; MAFF; MAFF; MAFF; MAFF; MAFG; MAFG; ZBTB21 (directAnnotation). ATF1; ATF1; ATF1; ATF1; ATF6; ATF6; ATF6; ATF6; ATF6B; ATF6B; ATF6B; ATF6B; CREB1; CREB1; CREB3; CREB3; CREB3; CREB3; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L2; CREB3L2; CREB3L2; CREB3L2; CREB3L3; CREB3L3; CREB3L3; CREB3L3; CREB3L4; CREB3L4; CREB3L4; CREB3L4; CREM; CREM; CREM; CREM; JDP2; JUN; JUNB; JUND; MAFB (inferredBy_Orthology).
GEM	transfac_public__M00039	CREB1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."