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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: GCA

Summary for GCA

Gene information	Gene symbol	GCA
	Ensembl ID	ENSG00000115271
	Entrez ID	25801
	Gene name	grancalcin
	Synonyms	GCL
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: GCA

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.857686	4.11e-05
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.258864	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	0.272961	2.31e-03
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.291712	6.59e-24
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	0.255948	5.37e-20
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.535391	8.90e-14
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	Mono/Macro	0.436682	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.411014	4.11e-08
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Mono/Macro	-0.369555	1.45e-32

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Expression of GCA in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GCA

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GCA

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GCA	hsa-miR-3658	95.7476	NM_012198
GCA	hsa-miR-3163	94.6219	NM_012198
GCA	hsa-miR-217-3p	91.5902	NM_012198
GCA	hsa-miR-4698	90.1947	NM_012198
GCA	hsa-miR-875-5p	90.0817	NM_012198
GCA	hsa-miR-4511	89.8662	NM_012198
GCA	hsa-miR-4777-3p	89.2987	NM_012198
GCA	hsa-miR-6885-3p	89.0631	NM_012198
GCA	hsa-miR-6753-5p	88.1422	NM_012198
GCA	hsa-miR-5681a	88.0354	NM_012198
GCA	hsa-miR-4686	87.848	NM_012198
GCA	hsa-miR-6837-3p	87.7325	NM_012198
GCA	hsa-miR-645	87.283	NM_012198
GCA	hsa-miR-548e-5p	87.2531	NM_012198
GCA	hsa-miR-4778-3p	85.6953	NM_012198
GCA	hsa-miR-369-3p	84.7467	NM_012198
GCA	hsa-miR-4422	83.2237	NM_012198
GCA	hsa-miR-323a-3p	82.5388	NM_012198
GCA	hsa-miR-6755-3p	80.9428	NM_012198
GCA	hsa-miR-153-5p	80.6583	NM_012198

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Motifs and transcription factors (TFs) regulating GCA

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GCA	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
GCA	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
GCA	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
GCA	transfac_pro__M02090	E2F4 (directAnnotation).
GCA	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
GCA	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
GCA	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
GCA	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
GCA	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
GCA	hdpi__HIP2	UBE2K (directAnnotation).
GCA	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
GCA	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
GCA	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
GCA	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
GCA	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
GCA	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
GCA	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
GCA	transfac_pro__M04944	GABPA (directAnnotation).
GCA	cisbp__M02645	ETS1 (directAnnotation).
GCA	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
GCA	cisbp__M02748	NFATC1 (directAnnotation).
GCA	tfdimers__MD00217	LTF; MZF1 (directAnnotation).
GCA	transfac_pro__M06786	ZNF646 (directAnnotation).
GCA	taipale_tf_pairs__HOXA3_PAX5_YNATTAGTCACGCWTSRNTR_CAP_repr	HOXA3; PAX5 (directAnnotation).
GCA	metacluster_175.3	GRHL1; TFCP2; TFCP2; TFCP2; TFCP2; TFCP2; TFCP2; TFCP2L1; TFCP2L1; UBP1; UBP1; ZNF217 (directAnnotation). GRHL1; GRHL2; GRHL3; TFCP2; TFCP2L1; TFCP2L1; TFCP2L1; TFCP2L1; UBP1 (inferredBy_Orthology).
GCA	transfac_pro__M06107	ZNF43 (directAnnotation).
GCA	transfac_pro__M06292	ZNF766 (directAnnotation).
GCA	metacluster_175.2	TFCP2L1; ZNF329; ZNF329 (directAnnotation). TFCP2L1; TFCP2L1 (inferredBy_Orthology).
GCA	swissregulon__hs__SPI1	SPI1 (directAnnotation).
GCA	taipale_tf_pairs__HOXB2_PAX5_NNMATTAGTCACGCWTSRNTG_CAP	HOXB2; PAX5 (directAnnotation).
GCA	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
GCA	metacluster_143.14	ZNF320 (directAnnotation).
GCA	kznf__ZNF383_Imbeault2017_RP_RCADE	ZNF383 (directAnnotation).
GCA	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
GCA	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
GCA	transfac_pro__M01973	PLAG1 (directAnnotation).
GCA	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
GCA	metacluster_66.1	MTF1; ZNF320; ZNF320; ZNF320; ZNF782 (directAnnotation).
GCA	cisbp__M01864	EGR1 (inferredBy_Orthology).
GCA	tfdimers__MD00391	KLF4 (directAnnotation).
GCA	cisbp__M00139	ZNF281 (inferredBy_Orthology).
GCA	metacluster_3.10	KLF2; KLF4 (directAnnotation).
GCA	jaspar__MA1122.1	TFDP1 (directAnnotation).
GCA	kznf__EGR2_Barrera2016.3_PBM	EGR2 (directAnnotation).
GCA	metacluster_23.8	GLIS1; GLIS1; GLIS1; GLIS2; GLIS2; GLIS2; GLIS2 (directAnnotation). GLIS2; GLIS3; ZXDA; ZXDB; ZXDC (inferredBy_Orthology).
GCA	metacluster_182.2	GCM1; GCM1; GCM1; GCM1; GCM2; GCM2 (directAnnotation). GCM1; GCM1; GCM1; GCM1; GCM2; GCM2 (inferredBy_Orthology).
GCA	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
GCA	cisbp__M00249	WT1 (directAnnotation).
GCA	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
GCA	transfac_pro__M12667	GPBP1L1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
GCA	"Calcium citrate"	DB11093	small molecule
GCA	"Calcium phosphate dihydrate"	DB14481	small molecule
GCA	"Calcium Phosphate"	DB11348	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."