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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: GATAD2B

Summary for GATAD2B

Gene information	Gene symbol	GATAD2B
	Ensembl ID	ENSG00000261992
	Entrez ID	57459
	Gene name	GATA zinc finger domain containing 2B
	Synonyms	P66beta
	Gene type	protein_coding
	UniProtAcc	Q8WXI9

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Dataset with differentially expressed gene: GATAD2B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.539716	0.00e+00

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Expression of GATAD2B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GATAD2B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GATAD2B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GATAD2B	hsa-miR-5011-5p	99.6387	NM_020699
GATAD2B	hsa-miR-1275	99.3129	NM_020699
GATAD2B	hsa-miR-4665-5p	97.7545	NM_020699
GATAD2B	hsa-miR-190a-3p	97.6154	NM_020699
GATAD2B	hsa-miR-4447	97.3975	NM_020699
GATAD2B	hsa-miR-590-3p	97.3679	NM_020699
GATAD2B	hsa-miR-21-5p	96.1514	NM_020699
GATAD2B	hsa-miR-590-5p	95.2483	NM_020699
GATAD2B	hsa-miR-524-5p	95.1373	NM_020699
GATAD2B	hsa-miR-520d-5p	95.1373	NM_020699
GATAD2B	hsa-miR-4775	94.4217	NM_020699
GATAD2B	hsa-miR-6821-3p	93.798	NM_020699
GATAD2B	hsa-miR-5681a	93.0015	NM_020699
GATAD2B	hsa-miR-4472	92.9868	NM_020699
GATAD2B	hsa-miR-6721-5p	92.9356	NM_020699
GATAD2B	hsa-miR-203b-3p	92.8722	NM_020699
GATAD2B	hsa-miR-3175	92.5156	NM_020699
GATAD2B	hsa-miR-651-3p	91.4725	NM_020699
GATAD2B	hsa-miR-625-5p	91.3418	NM_020699
GATAD2B	hsa-miR-5579-3p	91.2926	NM_020699
GATAD2B	hsa-miR-6130	91.0915	NM_020699
GATAD2B	hsa-miR-4510	91.0915	NM_020699
GATAD2B	hsa-miR-6129	91.0915	NM_020699
GATAD2B	hsa-miR-6133	91.0915	NM_020699
GATAD2B	hsa-miR-6127	91.0915	NM_020699
GATAD2B	hsa-miR-491-5p	90.999	NM_020699
GATAD2B	hsa-miR-4756-5p	90.2433	NM_020699
GATAD2B	hsa-miR-1321	90.2433	NM_020699
GATAD2B	hsa-miR-4739	90.2433	NM_020699
GATAD2B	hsa-miR-3190-3p	90.1234	NM_020699
GATAD2B	hsa-miR-561-5p	90.0287	NM_020699
GATAD2B	hsa-miR-4496	89.8064	NM_020699
GATAD2B	hsa-miR-6740-3p	89.6184	NM_020699
GATAD2B	hsa-miR-92a-2-5p	88.9389	NM_020699
GATAD2B	hsa-miR-519e-5p	88.5727	NM_020699
GATAD2B	hsa-miR-515-5p	88.5727	NM_020699
GATAD2B	hsa-miR-1207-5p	88.3763	NM_020699
GATAD2B	hsa-miR-519d-5p	87.898	NM_020699
GATAD2B	hsa-miR-6791-5p	87.7704	NM_020699
GATAD2B	hsa-miR-486-3p	87.2485	NM_020699
GATAD2B	hsa-miR-4763-3p	86.977	NM_020699
GATAD2B	hsa-miR-4292	85.6204	NM_020699
GATAD2B	hsa-miR-637	84.8302	NM_020699
GATAD2B	hsa-miR-6077	84.2289	NM_020699
GATAD2B	hsa-miR-4424	83.7228	NM_020699
GATAD2B	hsa-miR-3150a-3p	83.5964	NM_020699
GATAD2B	hsa-miR-6763-5p	83.5964	NM_020699
GATAD2B	hsa-miR-548an	83.3667	NM_020699
GATAD2B	hsa-miR-7974	82.4235	NM_020699
GATAD2B	hsa-miR-216a-5p	82.2477	NM_020699

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Motifs and transcription factors (TFs) regulating GATAD2B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GATAD2B	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
GATAD2B	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
GATAD2B	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
GATAD2B	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."