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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: GATA6

Summary for GATA6

Gene information	Gene symbol	GATA6
	Ensembl ID	ENSG00000141448
	Entrez ID	2627
	Gene name	GATA binding protein 6
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q92908

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Dataset with differentially expressed gene: GATA6

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.983147	0.00e+00

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Expression of GATA6 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GATA6

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
GATA6	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating GATA6

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GATA6	hsa-miR-4325	97.599	NM_005257
GATA6	hsa-miR-5589-3p	97.1745	NM_005257
GATA6	hsa-miR-130b-5p	96.383	NM_005257
GATA6	hsa-miR-196a-5p	96.1949	NM_005257
GATA6	hsa-miR-196b-5p	96.1949	NM_005257
GATA6	hsa-miR-4802-3p	95.751	NM_005257
GATA6	hsa-miR-4684-3p	95.4619	NM_005257
GATA6	hsa-miR-128-3p	95.3541	NM_005257
GATA6	hsa-miR-216a-3p	95.3541	NM_005257
GATA6	hsa-miR-3681-3p	95.1613	NM_005257
GATA6	hsa-miR-1200	94.6241	NM_005257
GATA6	hsa-miR-181a-5p	94.3106	NM_005257
GATA6	hsa-miR-4262	94.3106	NM_005257
GATA6	hsa-miR-181d-5p	94.3106	NM_005257
GATA6	hsa-miR-181b-5p	94.3106	NM_005257
GATA6	hsa-miR-181c-5p	94.3106	NM_005257
GATA6	hsa-miR-4299	94.2004	NM_005257
GATA6	hsa-miR-568	94.1046	NM_005257
GATA6	hsa-miR-548an	94.0592	NM_005257
GATA6	hsa-miR-6128	94.0478	NM_005257
GATA6	hsa-miR-6512-5p	93.4888	NM_005257
GATA6	hsa-miR-4528	92.5939	NM_005257
GATA6	hsa-miR-545-5p	92.2512	NM_005257
GATA6	hsa-miR-4677-5p	92.1377	NM_005257
GATA6	hsa-miR-4691-3p	92.0124	NM_005257
GATA6	hsa-miR-6832-3p	91.9834	NM_005257
GATA6	hsa-miR-567	91.9411	NM_005257
GATA6	hsa-miR-7-5p	91.674	NM_005257
GATA6	hsa-miR-7703	90.398	NM_005257
GATA6	hsa-miR-4704-3p	90.0307	NM_005257
GATA6	hsa-miR-6077	89.5652	NM_005257
GATA6	hsa-miR-27a-3p	89.5515	NM_005257
GATA6	hsa-miR-27b-3p	89.5515	NM_005257
GATA6	hsa-miR-9985	89.5515	NM_005257
GATA6	hsa-miR-372-5p	89.0658	NM_005257
GATA6	hsa-miR-6768-3p	89.0503	NM_005257
GATA6	hsa-miR-12122	88.9023	NM_005257
GATA6	hsa-miR-3163	88.5457	NM_005257
GATA6	hsa-miR-4324	88.3187	NM_005257
GATA6	hsa-miR-6739-3p	88.0761	NM_005257
GATA6	hsa-miR-32-5p	88.0535	NM_005257
GATA6	hsa-miR-92b-3p	88.0535	NM_005257
GATA6	hsa-miR-363-3p	88.0535	NM_005257
GATA6	hsa-miR-92a-3p	88.0535	NM_005257
GATA6	hsa-miR-25-3p	88.0535	NM_005257
GATA6	hsa-miR-367-3p	88.0535	NM_005257
GATA6	hsa-miR-124-3p	87.2246	NM_005257
GATA6	hsa-miR-506-3p	87.2246	NM_005257
GATA6	hsa-miR-10a-5p	87.0037	NM_005257
GATA6	hsa-miR-10b-5p	87.0037	NM_005257

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Motifs and transcription factors (TFs) regulating GATA6

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GATA6	metacluster_160.20	JUND; PRDM15 (directAnnotation).
GATA6	cisbp__M00341	PAX6 (directAnnotation).
GATA6	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
GATA6	metacluster_151.2	ZNF23 (directAnnotation).
GATA6	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
GATA6	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."