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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: GAS2L3

Summary for GAS2L3

Gene information	Gene symbol	GAS2L3
	Ensembl ID	ENSG00000139354
	Entrez ID	283431
	Gene name	growth arrest specific 2 like 3
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q86XJ1

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Dataset with differentially expressed gene: GAS2L3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.397743	4.43e-29

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Expression of GAS2L3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GAS2L3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GAS2L3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GAS2L3	hsa-miR-552-5p	97.2017	NM_174942
GAS2L3	hsa-miR-4775	94.486	NM_174942
GAS2L3	hsa-miR-4753-3p	92.9854	NM_174942
GAS2L3	hsa-miR-148a-5p	92.7047	NM_174942
GAS2L3	hsa-miR-142-3p	92.3495	NM_001303130
GAS2L3	hsa-miR-4499	90.2061	NM_174942
GAS2L3	hsa-miR-590-3p	90.0801	NM_174942
GAS2L3	hsa-miR-383-5p	89.5581	NM_174942
GAS2L3	hsa-miR-429	89.2662	NM_001303130
GAS2L3	hsa-miR-200b-3p	89.2662	NM_001303130
GAS2L3	hsa-miR-200c-3p	89.2662	NM_001303130
GAS2L3	hsa-miR-4255	89.2037	NM_001303130
GAS2L3	hsa-miR-6809-3p	88.8532	NM_174942
GAS2L3	hsa-miR-3074-5p	87.4297	NM_174942
GAS2L3	hsa-miR-892c-5p	86.1965	NM_001303130
GAS2L3	hsa-miR-4477a	85.9729	NM_174942
GAS2L3	hsa-miR-3942-3p	85.1237	NM_001303130
GAS2L3	hsa-miR-23b-3p	84.8143	NM_174942
GAS2L3	hsa-miR-23a-3p	84.8143	NM_174942
GAS2L3	hsa-miR-23c	84.8143	NM_174942
GAS2L3	hsa-miR-5003-5p	84.2303	NM_001303130
GAS2L3	hsa-miR-130a-5p	84.2006	NM_174942
GAS2L3	hsa-miR-5692a	83.5127	NM_174942
GAS2L3	hsa-miR-655-3p	83.3485	NM_001303130
GAS2L3	hsa-miR-374c-5p	83.3485	NM_001303130
GAS2L3	hsa-miR-7843-3p	83.1888	NM_174942
GAS2L3	hsa-miR-205-3p	83.1726	NM_174942
GAS2L3	hsa-miR-3662	82.663	NM_001303130
GAS2L3	hsa-miR-4772-5p	82.4648	NM_174942
GAS2L3	hsa-miR-624-3p	81.3688	NM_174942

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Motifs and transcription factors (TFs) regulating GAS2L3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GAS2L3	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
GAS2L3	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
GAS2L3	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
GAS2L3	jaspar__MA1933.1	SREBF2 (directAnnotation).
GAS2L3	metacluster_7.13	ZFX (directAnnotation).
GAS2L3	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
GAS2L3	cisbp__M01863	ZNF711 (inferredBy_Orthology).
GAS2L3	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
GAS2L3	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
GAS2L3	taipale_cyt_meth__KLF12_NGCCGACGCCCW_FL_meth_repr	KLF12 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."