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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: GAS1

Summary for GAS1

Gene information	Gene symbol	GAS1
	Ensembl ID	ENSG00000180447
	Entrez ID	2619
	Gene name	growth arrest specific 1
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P54826

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Dataset with differentially expressed gene: GAS1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.279564	1.76e-41

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Expression of GAS1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GAS1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GAS1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GAS1	hsa-miR-3714	94.9509	NM_002048
GAS1	hsa-miR-4796-5p	93.3728	NM_002048
GAS1	hsa-miR-449c-5p	93.0758	NM_002048
GAS1	hsa-miR-34b-5p	93.0758	NM_002048
GAS1	hsa-miR-2682-5p	93.0758	NM_002048
GAS1	hsa-miR-493-5p	93.0502	NM_002048
GAS1	hsa-miR-5688	92.2185	NM_002048
GAS1	hsa-miR-6753-5p	90.987	NM_002048
GAS1	hsa-miR-495-3p	90.7823	NM_002048
GAS1	hsa-miR-3163	90.7016	NM_002048
GAS1	hsa-miR-3133	88.7543	NM_002048
GAS1	hsa-miR-5093	88.0363	NM_002048
GAS1	hsa-miR-942-3p	86.7809	NM_002048
GAS1	hsa-miR-1284	86.122	NM_002048
GAS1	hsa-miR-374c-5p	85.8656	NM_002048
GAS1	hsa-miR-655-3p	85.8656	NM_002048
GAS1	hsa-miR-3908	85.2336	NM_002048
GAS1	hsa-miR-5582-3p	84.7397	NM_002048
GAS1	hsa-miR-548x-3p	84.1558	NM_002048
GAS1	hsa-miR-548aj-3p	84.1558	NM_002048
GAS1	hsa-miR-495-5p	83.9344	NM_002048
GAS1	hsa-miR-548au-3p	83.6949	NM_002048
GAS1	hsa-miR-4764-5p	82.0855	NM_002048
GAS1	hsa-miR-6795-5p	81.9159	NM_002048
GAS1	hsa-miR-6887-5p	81.9159	NM_002048
GAS1	hsa-miR-3159	80.8299	NM_002048
GAS1	hsa-miR-548aq-3p	80.7713	NM_002048
GAS1	hsa-miR-548ah-3p	80.7713	NM_002048
GAS1	hsa-miR-548j-3p	80.7713	NM_002048
GAS1	hsa-miR-548am-3p	80.7713	NM_002048
GAS1	hsa-miR-548ae-3p	80.7713	NM_002048
GAS1	hsa-miR-5689	80.4482	NM_002048
GAS1	hsa-miR-34a-5p	80.3043	NM_002048
GAS1	hsa-miR-449a	80.3043	NM_002048

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Motifs and transcription factors (TFs) regulating GAS1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GAS1	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
GAS1	taipale_tf_pairs__ETV2_RFX5_NNNTTCCGSNNNNGCAACNN_CAP_repr	ETV2; RFX5 (directAnnotation).
GAS1	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."