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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: GAP43

Summary for GAP43

Gene information	Gene symbol	GAP43
	Ensembl ID	ENSG00000172020
	Entrez ID	2596
	Gene name	growth associated protein 43
	Synonyms	B-50\|GAP-43\|PP46
	Gene type	protein_coding
	UniProtAcc	P17677

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Dataset with differentially expressed gene: GAP43

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.748689	0.00e+00

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Expression of GAP43 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GAP43

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GAP43

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GAP43	hsa-miR-6884-3p	98.0486	NM_001130064
GAP43	hsa-miR-4452	92.913	NM_002045
GAP43	hsa-miR-3064-3p	92.4549	NM_001130064
GAP43	hsa-miR-6766-5p	90.056	NM_002045
GAP43	hsa-miR-6756-5p	90.056	NM_002045
GAP43	hsa-miR-196a-1-3p	89.3233	NM_001130064
GAP43	hsa-miR-12133	88.1013	NM_001130064
GAP43	hsa-miR-96-5p	88.1013	NM_001130064
GAP43	hsa-miR-1271-5p	88.1013	NM_001130064
GAP43	hsa-miR-152-3p	87.501	NM_001130064
GAP43	hsa-miR-148b-3p	87.501	NM_001130064
GAP43	hsa-miR-148a-3p	87.501	NM_001130064
GAP43	hsa-miR-449b-3p	87.1134	NM_001130064
GAP43	hsa-miR-4468	85.5487	NM_001130064
GAP43	hsa-miR-6856-5p	85.3721	NM_002045
GAP43	hsa-miR-3614-5p	84.7339	NM_002045
GAP43	hsa-miR-23a-3p	83.5755	NM_001130064
GAP43	hsa-miR-23c	83.5755	NM_001130064
GAP43	hsa-miR-23b-3p	83.5755	NM_001130064
GAP43	hsa-miR-6853-3p	83.2039	NM_002045
GAP43	hsa-miR-4776-3p	83.1266	NM_001130064
GAP43	hsa-miR-92a-2-5p	83.0718	NM_002045
GAP43	hsa-miR-890	82.481	NM_002045
GAP43	hsa-miR-3074-5p	82.1796	NM_001130064
GAP43	hsa-miR-759	82.1151	NM_001130064
GAP43	hsa-miR-4721	80.2802	NM_002045

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Motifs and transcription factors (TFs) regulating GAP43

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GAP43	hocomoco__OTX1_HUMAN.H11MO.0.D	OTX1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."