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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: GABPB1

Summary for GABPB1

Gene information	Gene symbol	GABPB1
	Ensembl ID	ENSG00000104064
	Entrez ID	2553
	Gene name	GA binding protein transcription factor subunit beta 1
	Synonyms	E4TF1-47\|GABPB\|GABPB2
	Gene type	protein_coding
	UniProtAcc	Q06547

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Dataset with differentially expressed gene: GABPB1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	pre	Malignant cells	-0.265741	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.367914	0.00e+00

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Expression of GABPB1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GABPB1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GABPB1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GABPB1	hsa-miR-4328	99.3822	NM_005254
GABPB1	hsa-miR-582-5p	99.1992	NM_005254
GABPB1	hsa-miR-4718	98.5526	NM_005254
GABPB1	hsa-miR-551b-5p	98.1715	NM_005254
GABPB1	hsa-miR-3613-3p	97.5825	NM_005254
GABPB1	hsa-let-7c-3p	96.4939	NM_005254
GABPB1	hsa-miR-6783-3p	96.4928	NM_005254
GABPB1	hsa-miR-144-3p	96.3707	NM_005254
GABPB1	hsa-miR-1343-3p	94.9725	NM_005254
GABPB1	hsa-miR-451b	94.5389	NM_005254
GABPB1	hsa-miR-513b-5p	93.9074	NM_005254
GABPB1	hsa-miR-7-1-3p	93.068	NM_005254
GABPB1	hsa-miR-7-2-3p	93.068	NM_005254
GABPB1	hsa-miR-3163	92.9089	NM_005254
GABPB1	hsa-miR-6878-5p	92.6162	NM_005254
GABPB1	hsa-miR-302f	92.1931	NM_005254
GABPB1	hsa-miR-539-5p	91.5144	NM_005254
GABPB1	hsa-miR-4251	91.4134	NM_005254
GABPB1	hsa-miR-3121-3p	91.143	NM_005254
GABPB1	hsa-miR-3160-5p	90.9802	NM_005254
GABPB1	hsa-miR-101-3p	90.9514	NM_005254
GABPB1	hsa-miR-141-3p	90.366	NM_005254
GABPB1	hsa-miR-6835-3p	89.8699	NM_005254
GABPB1	hsa-miR-6515-3p	89.5642	NM_005254
GABPB1	hsa-miR-6852-5p	89.2182	NM_005254
GABPB1	hsa-miR-942-5p	88.7939	NM_005254
GABPB1	hsa-let-7f-2-3p	88.2558	NM_005254
GABPB1	hsa-miR-1185-1-3p	88.2558	NM_005254
GABPB1	hsa-miR-1185-2-3p	88.2558	NM_005254
GABPB1	hsa-miR-548aj-3p	88.0357	NM_005254
GABPB1	hsa-miR-548x-3p	88.0357	NM_005254
GABPB1	hsa-miR-200a-3p	87.4356	NM_005254
GABPB1	hsa-miR-944	87.4191	NM_005254
GABPB1	hsa-miR-559	87.3345	NM_005254
GABPB1	hsa-miR-548j-3p	87.1756	NM_005254
GABPB1	hsa-miR-548aq-3p	87.1756	NM_005254
GABPB1	hsa-miR-548am-3p	87.1756	NM_005254
GABPB1	hsa-miR-548ae-3p	87.1756	NM_005254
GABPB1	hsa-miR-548ah-3p	87.1756	NM_005254
GABPB1	hsa-miR-7112-3p	86.6589	NM_005254
GABPB1	hsa-miR-548ar-3p	86.0128	NM_005254
GABPB1	hsa-miR-4422	84.6796	NM_005254
GABPB1	hsa-miR-134-3p	84.6624	NM_005254
GABPB1	hsa-miR-3175	84.6603	NM_005254
GABPB1	hsa-miR-4797-5p	84.6386	NM_005254
GABPB1	hsa-miR-1226-5p	84.542	NM_002041
GABPB1	hsa-miR-20a-5p	84.0419	NM_005254
GABPB1	hsa-miR-106b-5p	84.0419	NM_005254
GABPB1	hsa-miR-548e-3p	83.5998	NM_005254
GABPB1	hsa-miR-548a-3p	83.5998	NM_005254

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Motifs and transcription factors (TFs) regulating GABPB1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GABPB1	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
GABPB1	hdpi__TP73	TP73 (directAnnotation).
GABPB1	transfac_pro__M06259	ZNF91 (directAnnotation).
GABPB1	metacluster_141.2	E2F2; E2F3 (directAnnotation).
GABPB1	transfac_pro__M05617	ZNF500 (directAnnotation).
GABPB1	hdpi__HTATIP2	HTATIP2 (directAnnotation).
GABPB1	jaspar__MA1460.1	YY1 (inferredBy_Orthology).
GABPB1	hdpi__NRL	NRL (directAnnotation).
GABPB1	transfac_pro__M04916	TAF1 (directAnnotation).
GABPB1	taipale_tf_pairs__E2F1_NHLH1_SGCGCCNNNNNNNNNNNNCAGCTGNN_CAP_repr	E2F1; NHLH1 (directAnnotation).
GABPB1	transfac_pro__M01269	NR4A2 (directAnnotation).
GABPB1	transfac_pro__M01199	TRIM28 (directAnnotation).
GABPB1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
GABPB1	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
GABPB1	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
GABPB1	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
GABPB1	jaspar__MA1483.2	ELF2 (directAnnotation).
GABPB1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
GABPB1	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
GABPB1	swissregulon__hs__ETV6	ETV6 (directAnnotation).
GABPB1	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
GABPB1	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
GABPB1	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
GABPB1	swissregulon__hs__ELF2	ELF2 (directAnnotation).
GABPB1	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
GABPB1	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
GABPB1	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
GABPB1	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
GABPB1	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
GABPB1	hdpi__ETV4	ETV4 (directAnnotation).
GABPB1	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
GABPB1	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
GABPB1	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
GABPB1	taipale_tf_pairs__ERF_TBX21_TMACACCGGAAG_CAP	ERF; TBX21 (directAnnotation).
GABPB1	kznf__ZNF441_Imbeault2017_OM_RCADE	ZNF441 (directAnnotation).
GABPB1	cisbp__M02645	ETS1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
GABPB1	metacluster_166.4	down	Malignant cells	GSE164897_VemCob	NA
GABPB1	metacluster_166.4	down	Malignant cells	GSE164897_VemCob	NA

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."