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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: G0S2

Summary for G0S2

Gene information	Gene symbol	G0S2
	Ensembl ID	ENSG00000123689
	Entrez ID	50486
	Gene name	G0/G1 switch 2
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P27469

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Dataset with differentially expressed gene: G0S2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mono/Macro	0.714833	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	-0.524829	3.90e-19
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	1.95496	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.859013	4.91e-02
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.441497	4.62e-16
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	1.30756	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.808093	7.66e-05
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Mono/Macro	-0.966654	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Mono/Macro	0.506842	4.12e-16
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Mono/Macro	0.672046	2.85e-29
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-1.87057	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Mono/Macro	-0.672418	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	2.79561	0.00e+00

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Expression of G0S2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to G0S2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating G0S2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
G0S2	hsa-miR-4698	97.9399	NM_015714
G0S2	hsa-miR-12136	97.0748	NM_015714
G0S2	hsa-miR-548aw	96.9583	NM_015714
G0S2	hsa-miR-2054	95.5931	NM_015714
G0S2	hsa-miR-4277	94.8245	NM_015714
G0S2	hsa-miR-1468-3p	94.5493	NM_015714
G0S2	hsa-miR-323a-5p	93.8471	NM_015714
G0S2	hsa-miR-3666	90.1071	NM_015714
G0S2	hsa-miR-454-3p	88.7164	NM_015714
G0S2	hsa-miR-301a-3p	87.6258	NM_015714
G0S2	hsa-miR-130a-3p	87.6258	NM_015714
G0S2	hsa-miR-4295	87.6258	NM_015714
G0S2	hsa-miR-130b-3p	87.6258	NM_015714
G0S2	hsa-miR-301b-3p	87.6258	NM_015714
G0S2	hsa-miR-205-3p	86.3166	NM_015714
G0S2	hsa-miR-548e-5p	82.1696	NM_015714
G0S2	hsa-miR-15b-5p	80.7394	NM_015714
G0S2	hsa-miR-6838-5p	80.7394	NM_015714
G0S2	hsa-miR-195-5p	80.7394	NM_015714
G0S2	hsa-miR-16-5p	80.7394	NM_015714
G0S2	hsa-miR-15a-5p	80.7394	NM_015714

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Motifs and transcription factors (TFs) regulating G0S2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
G0S2	transfac_pro__M05667	ZNF35 (directAnnotation).
G0S2	metacluster_53.2	ZNF8 (directAnnotation).
G0S2	taipale_tf_pairs__ETV2_TEF_TTACGTNNNNNNNNNCCGGAANN_CAP_repr	ETV2; TEF (directAnnotation).
G0S2	tfdimers__MD00381	SOX10 (directAnnotation).
G0S2	metacluster_103.2	ZNF136; ZNF680 (directAnnotation).
G0S2	transfac_pro__M05475	ZBTB41 (directAnnotation).
G0S2	transfac_pro__M05916	ZNF407 (directAnnotation).
G0S2	metacluster_2.7	IRF1; IRF1; IRF2; IRF2; IRF3; IRF4; IRF5; IRF6; IRF7; IRF7; IRF8; IRF8; IRF9; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; STAT1; STAT1; STAT2 (directAnnotation). PRDM1; PRDM1; PRDM1 (inferredBy_Orthology).
G0S2	transfac_pro__M05935	ZNF382 (directAnnotation).
G0S2	taipale_tf_pairs__FOXJ2_HOXB13_TTTWATNRNMAACA_CAP_repr	FOXJ2; HOXB13 (directAnnotation).
G0S2	tfdimers__MD00466	MYB; SPI1 (directAnnotation).
G0S2	tfdimers__MD00351	IRF8; RFX1; RFX2; RFX3; RFX4; RFX5; RFXANK; RFXAP (directAnnotation).
G0S2	taipale_tf_pairs__TEAD4_PITX1_RCATWCYNNNNTAATCC_CAP_repr	PITX1; TEAD4 (directAnnotation).
G0S2	metacluster_76.1	ZNF345; ZNF345 (directAnnotation). MYB; MYBL1 (inferredBy_Orthology).
G0S2	hdpi__ETS1	ETS1 (directAnnotation).
G0S2	swissregulon__hs__CEBPB	CEBPB (directAnnotation).
G0S2	tfdimers__MD00449	REL; YY1 (directAnnotation).
G0S2	jaspar__MA1721.1	ZNF93 (directAnnotation).
G0S2	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
G0S2	jaspar__MA0748.2	YY2 (directAnnotation).
G0S2	hdpi__ZNF131	ZNF131 (directAnnotation).
G0S2	jaspar__MA1154.1	ZNF282 (directAnnotation).
G0S2	metacluster_167.7	IRF8 (inferredBy_Orthology).
G0S2	metacluster_168.4	ZNF652 (directAnnotation).
G0S2	transfac_pro__M06141	ZNF708 (directAnnotation).
G0S2	tfdimers__MD00221	FOXG1; FOXO1; GABPA (directAnnotation).
G0S2	jaspar__MA1939.1	SREBF2 (directAnnotation).
G0S2	tfdimers__MD00051	GABPA; STAT6 (directAnnotation).
G0S2	tfdimers__MD00143	IKZF1; MZF1 (directAnnotation).
G0S2	kznf__ZNF77_Imbeault2017_OM_MEME	ZNF77 (directAnnotation).
G0S2	hocomoco__ZN713_HUMAN.H11MO.0.D	ZNF713 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."