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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FZD7

Summary for FZD7

Gene information	Gene symbol	FZD7
	Ensembl ID	ENSG00000155760
	Entrez ID	8324
	Gene name	frizzled class receptor 7
	Synonyms	FzE3
	Gene type	protein_coding
	UniProtAcc	O75084

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Dataset with differentially expressed gene: FZD7

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.359393	1.75e-27

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Expression of FZD7 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FZD7

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
FZD7	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating FZD7

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FZD7	hsa-miR-4325	95.4863	NM_003507
FZD7	hsa-miR-559	95.4547	NM_003507
FZD7	hsa-miR-548j-5p	95.2093	NM_003507
FZD7	hsa-miR-548y	95.2093	NM_003507
FZD7	hsa-miR-548d-5p	95.2093	NM_003507
FZD7	hsa-miR-548h-5p	95.2093	NM_003507
FZD7	hsa-miR-548o-5p	95.2093	NM_003507
FZD7	hsa-miR-548au-5p	95.2093	NM_003507
FZD7	hsa-miR-548ay-5p	95.2093	NM_003507
FZD7	hsa-miR-548ae-5p	95.2093	NM_003507
FZD7	hsa-miR-548am-5p	95.2093	NM_003507
FZD7	hsa-miR-548a-5p	95.2093	NM_003507
FZD7	hsa-miR-548b-5p	95.2093	NM_003507
FZD7	hsa-miR-548bb-5p	95.2093	NM_003507
FZD7	hsa-miR-548ad-5p	95.2093	NM_003507
FZD7	hsa-miR-548ab	95.2093	NM_003507
FZD7	hsa-miR-548ak	95.2093	NM_003507
FZD7	hsa-miR-548ar-5p	95.2093	NM_003507
FZD7	hsa-miR-548aq-5p	95.2093	NM_003507
FZD7	hsa-miR-548ap-5p	95.2093	NM_003507
FZD7	hsa-miR-548as-5p	95.2093	NM_003507
FZD7	hsa-miR-548i	95.2093	NM_003507
FZD7	hsa-miR-548c-5p	95.2093	NM_003507
FZD7	hsa-miR-548w	95.2093	NM_003507
FZD7	hsa-miR-6878-5p	94.7683	NM_003507
FZD7	hsa-miR-6871-5p	92.9238	NM_003507
FZD7	hsa-miR-3660	91.3992	NM_003507
FZD7	hsa-miR-4526	91.3992	NM_003507
FZD7	hsa-miR-2355-5p	91.0938	NM_003507
FZD7	hsa-miR-2052	89.211	NM_003507
FZD7	hsa-miR-338-5p	87.5546	NM_003507
FZD7	hsa-miR-4668-3p	87.4414	NM_003507
FZD7	hsa-miR-6728-3p	86.7241	NM_003507
FZD7	hsa-miR-451b	86.4961	NM_003507
FZD7	hsa-miR-6881-3p	85.8374	NM_003507
FZD7	hsa-miR-4308	85.718	NM_003507
FZD7	hsa-miR-6818-3p	85.2894	NM_003507
FZD7	hsa-miR-627-3p	84.2286	NM_003507
FZD7	hsa-miR-3675-3p	83.8949	NM_003507
FZD7	hsa-miR-4796-3p	83.3915	NM_003507
FZD7	hsa-miR-3973	82.9189	NM_003507
FZD7	hsa-miR-4725-5p	82.8945	NM_003507
FZD7	hsa-miR-504-5p	82.8945	NM_003507
FZD7	hsa-miR-4297	82.5284	NM_003507
FZD7	hsa-miR-6756-5p	82.2683	NM_003507
FZD7	hsa-miR-3059-5p	82.2197	NM_003507
FZD7	hsa-miR-5581-5p	81.2477	NM_003507

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Motifs and transcription factors (TFs) regulating FZD7

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FZD7	transfac_pro__M05976	ZNF223 (directAnnotation).
FZD7	hdpi__MYEF2	MYEF2 (directAnnotation).
FZD7	metacluster_141.4	GLIS2 (directAnnotation).
FZD7	transfac_pro__M04950	EGR1 (directAnnotation).
FZD7	transfac_pro__M06135	ZNF28 (directAnnotation).
FZD7	transfac_pro__M04913	ZBTB7A (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."