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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FZD2

Summary for FZD2

Gene information	Gene symbol	FZD2
	Ensembl ID	ENSG00000180340
	Entrez ID	2535
	Gene name	frizzled class receptor 2
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q14332

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Dataset with differentially expressed gene: FZD2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.528178	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.300667	0.00e+00

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Expression of FZD2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FZD2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FZD2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FZD2	hsa-miR-3121-3p	94.9006	NM_001466
FZD2	hsa-miR-5011-5p	94.778	NM_001466
FZD2	hsa-miR-3119	93.4497	NM_001466
FZD2	hsa-miR-6780b-5p	92.9663	NM_001466
FZD2	hsa-miR-4725-3p	92.9663	NM_001466
FZD2	hsa-miR-4271	92.5783	NM_001466
FZD2	hsa-miR-548t-5p	92.1028	NM_001466
FZD2	hsa-miR-548az-5p	92.1028	NM_001466
FZD2	hsa-miR-373-5p	91.5429	NM_001466
FZD2	hsa-miR-616-5p	91.5429	NM_001466
FZD2	hsa-miR-371b-5p	91.5429	NM_001466
FZD2	hsa-miR-4795-3p	89.6462	NM_001466
FZD2	hsa-miR-4753-3p	88.143	NM_001466
FZD2	hsa-miR-3689a-5p	88.0435	NM_001466
FZD2	hsa-miR-3689f	88.0435	NM_001466
FZD2	hsa-miR-3689e	88.0435	NM_001466
FZD2	hsa-miR-3689b-5p	88.0435	NM_001466
FZD2	hsa-miR-934	87.1957	NM_001466
FZD2	hsa-miR-520d-5p	85.2729	NM_001466
FZD2	hsa-miR-524-5p	85.2729	NM_001466
FZD2	hsa-miR-130a-5p	84.0737	NM_001466
FZD2	hsa-miR-3163	84.0645	NM_001466
FZD2	hsa-miR-6834-5p	82.8606	NM_001466
FZD2	hsa-miR-4638-3p	82.5117	NM_001466
FZD2	hsa-miR-6722-3p	82.3968	NM_001466
FZD2	hsa-miR-1266-3p	81.6091	NM_001466
FZD2	hsa-miR-6842-5p	80.9092	NM_001466
FZD2	hsa-miR-7110-5p	80.9092	NM_001466
FZD2	hsa-miR-3927-5p	80.7919	NM_001466
FZD2	hsa-miR-4284	80.1215	NM_001466

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Motifs and transcription factors (TFs) regulating FZD2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FZD2	metacluster_3.14	WT1; WT1 (directAnnotation).
FZD2	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."