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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FYTTD1

Summary for FYTTD1

Gene information	Gene symbol	FYTTD1
	Ensembl ID	ENSG00000122068
	Entrez ID	84248
	Gene name	forty-two-three domain containing 1
	Synonyms	DKFZp761B1514\|UIF
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: FYTTD1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.320197	2.55e-09
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.266699	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.296372	1.29e-11
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.462545	0.00e+00

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Expression of FYTTD1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FYTTD1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FYTTD1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FYTTD1	hsa-miR-4666a-3p	99.4285	NM_001011537
FYTTD1	hsa-miR-300	97.1358	NM_001011537
FYTTD1	hsa-miR-381-3p	97.1358	NM_001011537
FYTTD1	hsa-miR-19b-2-5p	96.3963	NM_001011537
FYTTD1	hsa-miR-19a-5p	96.3963	NM_001011537
FYTTD1	hsa-miR-19b-1-5p	96.3963	NM_001011537
FYTTD1	hsa-miR-518a-5p	94.978	NM_001011537
FYTTD1	hsa-miR-527	94.978	NM_001011537
FYTTD1	hsa-miR-5683	94.2351	NM_001011537
FYTTD1	hsa-miR-21-3p	94.2111	NM_001011537
FYTTD1	hsa-miR-122b-3p	94.2111	NM_001011537
FYTTD1	hsa-miR-2052	93.8727	NM_001011537
FYTTD1	hsa-miR-561-3p	93.0711	NM_001011537
FYTTD1	hsa-miR-548bb-3p	92.7343	NM_001011537
FYTTD1	hsa-miR-548z	92.7343	NM_001011537
FYTTD1	hsa-miR-548h-3p	92.7343	NM_001011537
FYTTD1	hsa-miR-548ac	92.7343	NM_001011537
FYTTD1	hsa-miR-548d-3p	92.7343	NM_001011537
FYTTD1	hsa-miR-5003-3p	92.6816	NM_001011537
FYTTD1	hsa-miR-502-5p	92.2748	NM_001011537
FYTTD1	hsa-miR-3127-5p	91.9926	NM_001011537
FYTTD1	hsa-miR-3613-3p	91.9314	NM_001011537
FYTTD1	hsa-miR-98-3p	91.6196	NM_001011537
FYTTD1	hsa-let-7f-1-3p	91.6196	NM_001011537
FYTTD1	hsa-let-7b-3p	91.6196	NM_001011537
FYTTD1	hsa-let-7a-3p	91.6196	NM_001011537
FYTTD1	hsa-miR-449c-3p	91.0947	NM_001011537
FYTTD1	hsa-miR-9-5p	90.7006	NM_001011537
FYTTD1	hsa-miR-4773	88.0031	NM_001011537
FYTTD1	hsa-miR-10522-5p	87.9434	NM_001011537
FYTTD1	hsa-miR-4680-5p	87.6042	NM_001011537
FYTTD1	hsa-miR-3671	87.3445	NM_001011537
FYTTD1	hsa-miR-4724-5p	86.2068	NM_001011537
FYTTD1	hsa-miR-3611	86.0707	NM_001011537
FYTTD1	hsa-miR-4422	84.5322	NM_001011537
FYTTD1	hsa-miR-548x-3p	84.0183	NM_001011537
FYTTD1	hsa-miR-548aj-3p	84.0183	NM_001011537
FYTTD1	hsa-miR-607	83.6736	NM_001011537
FYTTD1	hsa-miR-6841-3p	83.1919	NM_001011537
FYTTD1	hsa-miR-6874-5p	82.7915	NM_001011537
FYTTD1	hsa-miR-676-5p	82.4826	NM_001011537
FYTTD1	hsa-miR-1284	82.0499	NM_001011537
FYTTD1	hsa-miR-548aq-3p	81.9218	NM_001011537
FYTTD1	hsa-miR-548ah-3p	81.9218	NM_001011537
FYTTD1	hsa-miR-548ae-3p	81.9218	NM_001011537
FYTTD1	hsa-miR-548j-3p	81.9218	NM_001011537
FYTTD1	hsa-miR-548am-3p	81.9218	NM_001011537
FYTTD1	hsa-miR-6868-3p	81.5624	NM_001011537
FYTTD1	hsa-miR-6844	81.4114	NM_001011537

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Motifs and transcription factors (TFs) regulating FYTTD1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FYTTD1	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
FYTTD1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
FYTTD1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
FYTTD1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
FYTTD1	transfac_pro__M04950	EGR1 (directAnnotation).
FYTTD1	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
FYTTD1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
FYTTD1	transfac_pro__M00652	NRF1 (directAnnotation).
FYTTD1	hdpi__ETV4	ETV4 (directAnnotation).
FYTTD1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
FYTTD1	transfac_pro__M04866	HDAC2 (directAnnotation).
FYTTD1	jaspar__MA1122.1	TFDP1 (directAnnotation).
FYTTD1	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
FYTTD1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
FYTTD1	metacluster_135.11	NR2C2 (directAnnotation).
FYTTD1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
FYTTD1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
FYTTD1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
FYTTD1	cisbp__M00968	MTF2 (directAnnotation).
FYTTD1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
FYTTD1	cisbp__M00341	PAX6 (directAnnotation).
FYTTD1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
FYTTD1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
FYTTD1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
FYTTD1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
FYTTD1	metacluster_175.1	ZNF283 (directAnnotation).
FYTTD1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
FYTTD1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
FYTTD1	metacluster_151.2	ZNF23 (directAnnotation).
FYTTD1	transfac_pro__M03806	ZBTB7C (directAnnotation).
FYTTD1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
FYTTD1	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
FYTTD1	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
FYTTD1	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
FYTTD1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
FYTTD1	taipale_cyt_meth__ZNF460_NAACGCCCCCCGN_eDBD_repr	ZNF460 (directAnnotation).
FYTTD1	transfac_pro__M01253	CNOT3 (directAnnotation).
FYTTD1	transfac_pro__M04817	ZBTB33 (directAnnotation).
FYTTD1	cisbp__M07938	E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."