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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FYCO1

Summary for FYCO1

Gene information	Gene symbol	FYCO1
	Ensembl ID	ENSG00000163820
	Entrez ID	79443
	Gene name	FYVE and coiled-coil domain autophagy adaptor 1
	Synonyms	FLJ13335\|ZFYVE7
	Gene type	protein_coding
	UniProtAcc	Q9BQS8

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Dataset with differentially expressed gene: FYCO1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.252794	1.83e-35

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Expression of FYCO1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FYCO1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FYCO1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FYCO1	hsa-miR-20a-5p	99.7302	NM_024513
FYCO1	hsa-miR-106b-5p	99.7302	NM_024513
FYCO1	hsa-miR-519d-3p	99.7258	NM_024513
FYCO1	hsa-miR-93-5p	99.7258	NM_024513
FYCO1	hsa-miR-17-5p	99.7258	NM_024513
FYCO1	hsa-miR-20b-5p	99.7258	NM_024513
FYCO1	hsa-miR-526b-3p	99.7113	NM_024513
FYCO1	hsa-miR-106a-5p	99.7113	NM_024513
FYCO1	hsa-miR-3085-3p	97.2307	NM_024513
FYCO1	hsa-miR-6504-5p	97.2307	NM_024513
FYCO1	hsa-miR-3064-5p	97.2307	NM_024513
FYCO1	hsa-miR-544b	96.7838	NM_024513
FYCO1	hsa-miR-655-5p	96.3209	NM_024513
FYCO1	hsa-miR-9-5p	95.5007	NM_024513
FYCO1	hsa-miR-6728-3p	92.6516	NM_024513
FYCO1	hsa-miR-4297	92.6322	NM_024513
FYCO1	hsa-miR-7150	92.5084	NM_024513
FYCO1	hsa-miR-302e	92.0497	NM_024513
FYCO1	hsa-miR-5571-5p	91.9979	NM_024513
FYCO1	hsa-miR-182-3p	91.8243	NM_024513
FYCO1	hsa-miR-3920	91.4027	NM_024513
FYCO1	hsa-miR-520d-3p	90.9389	NM_024513
FYCO1	hsa-miR-4753-5p	90.9334	NM_024513
FYCO1	hsa-miR-4725-3p	90.7341	NM_024513
FYCO1	hsa-miR-520f-3p	90.4842	NM_024513
FYCO1	hsa-miR-5581-5p	90.0772	NM_024513
FYCO1	hsa-miR-597-3p	89.9139	NM_024513
FYCO1	hsa-miR-1271-5p	89.88	NM_024513
FYCO1	hsa-miR-12133	89.88	NM_024513
FYCO1	hsa-miR-96-5p	89.3167	NM_024513
FYCO1	hsa-miR-182-5p	89.3167	NM_024513
FYCO1	hsa-miR-6780b-5p	89.2753	NM_024513
FYCO1	hsa-miR-373-3p	88.1558	NM_024513
FYCO1	hsa-miR-520b-3p	88.128	NM_024513
FYCO1	hsa-miR-302d-3p	88.128	NM_024513
FYCO1	hsa-miR-302c-3p	88.128	NM_024513
FYCO1	hsa-miR-520e-3p	88.128	NM_024513
FYCO1	hsa-miR-520a-3p	88.128	NM_024513
FYCO1	hsa-miR-372-3p	88.128	NM_024513
FYCO1	hsa-miR-302a-3p	88.128	NM_024513
FYCO1	hsa-miR-302b-3p	88.128	NM_024513
FYCO1	hsa-miR-520c-3p	88.128	NM_024513
FYCO1	hsa-miR-4640-5p	88.003	NM_024513
FYCO1	hsa-miR-874-5p	87.9507	NM_024513
FYCO1	hsa-miR-4726-5p	87.9358	NM_024513
FYCO1	hsa-miR-4796-3p	87.0412	NM_024513
FYCO1	hsa-miR-4282	86.8611	NM_024513
FYCO1	hsa-miR-152-5p	86.4915	NM_024513
FYCO1	hsa-miR-4271	86.454	NM_024513
FYCO1	hsa-miR-4717-5p	85.4938	NM_024513

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Motifs and transcription factors (TFs) regulating FYCO1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FYCO1	metacluster_7.13	ZFX (directAnnotation).
FYCO1	transfac_pro__M05479	ZNF580 (directAnnotation).
FYCO1	hdpi__ETV4	ETV4 (directAnnotation).
FYCO1	transfac_pro__M05628	ZNF735 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."