Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: FURIN

Summary for FURIN

Gene information	Gene symbol	FURIN
	Ensembl ID	ENSG00000140564
	Entrez ID	5045
	Gene name	furin, paired basic amino acid cleaving enzyme
	Synonyms	FUR\|PACE\|PCSK3\|SPC1
	Gene type	protein_coding
	UniProtAcc	P09958

Top

Dataset with differentially expressed gene: FURIN

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.321708	1.69e-29
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD4+ T cells	0.559428	2.11e-23
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.292116	4.75e-03
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD4+ T cells	-0.605595	8.66e-21
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.368364	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	0.250308	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-1.18375	0.00e+00

Top

Expression of FURIN in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to FURIN

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating FURIN

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FURIN	hsa-miR-34b-3p	97.8264	NM_001289823
FURIN	hsa-miR-4728-5p	97.8236	NM_001289823
FURIN	hsa-miR-6785-5p	97.1322	NM_001289823
FURIN	hsa-miR-6883-5p	95.5483	NM_001289823
FURIN	hsa-miR-149-3p	95.5483	NM_001289823
FURIN	hsa-miR-9-5p	93.4878	NM_001289823
FURIN	hsa-miR-137-3p	93.4395	NM_001289823
FURIN	hsa-miR-520g-3p	92.1452	NM_001289823
FURIN	hsa-miR-520h	92.1452	NM_001289823
FURIN	hsa-miR-7855-5p	91.8716	NM_001289823
FURIN	hsa-miR-4283	91.2219	NM_001289823
FURIN	hsa-miR-885-5p	90.405	NM_001289823
FURIN	hsa-miR-515-5p	90.0389	NM_001289823
FURIN	hsa-miR-519e-5p	90.0389	NM_001289823
FURIN	hsa-miR-548ah-5p	89.3398	NM_001289823
FURIN	hsa-miR-676-3p	88.6528	NM_001289823
FURIN	hsa-miR-634	88.3997	NM_001289823
FURIN	hsa-miR-3609	88.344	NM_001289823
FURIN	hsa-miR-6755-5p	88.0217	NM_001289823
FURIN	hsa-miR-3912-5p	87.9501	NM_001289823
FURIN	hsa-miR-153-3p	87.2099	NM_001289823
FURIN	hsa-miR-5088-3p	85.9729	NM_001289823
FURIN	hsa-miR-6778-3p	85.838	NM_001289823
FURIN	hsa-miR-4286	85.103	NM_001289823
FURIN	hsa-miR-24-3p	83.4288	NM_001289823
FURIN	hsa-miR-3132	83.3226	NM_001289823
FURIN	hsa-miR-197-5p	83.1575	NM_001289823
FURIN	hsa-miR-6766-3p	82.892	NM_001289823
FURIN	hsa-miR-219a-5p	82.892	NM_001289823
FURIN	hsa-miR-4782-3p	82.892	NM_001289823
FURIN	hsa-miR-1226-3p	82.2699	NM_001289823
FURIN	hsa-miR-6798-3p	82.0976	NM_001289823
FURIN	hsa-miR-6766-5p	81.7716	NM_001289823
FURIN	hsa-miR-6756-5p	81.7614	NM_001289823
FURIN	hsa-miR-4749-3p	81.6013	NM_001289823
FURIN	hsa-miR-3121-3p	81.1506	NM_001289823
FURIN	hsa-miR-7106-5p	80.7652	NM_001289823
FURIN	hsa-miR-506-3p	80.3642	NM_001289823
FURIN	hsa-miR-124-3p	80.3642	NM_001289823

Page: 1

Top

Motifs and transcription factors (TFs) regulating FURIN

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FURIN	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
FURIN	metacluster_7.13	ZFX (directAnnotation).
FURIN	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
FURIN	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
FURIN	cisbp__M00341	PAX6 (directAnnotation).
FURIN	metacluster_198.3	ZFP64 (directAnnotation).
FURIN	cisbp__M00788	ZFY (inferredBy_Orthology).
FURIN	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
FURIN	transfac_pro__M01199	TRIM28 (directAnnotation).
FURIN	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
FURIN	transfac_pro__M03806	ZBTB7C (directAnnotation).
FURIN	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
FURIN	cisbp__M01863	ZNF711 (inferredBy_Orthology).
FURIN	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
FURIN	transfac_pro__M01253	CNOT3 (directAnnotation).
FURIN	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
FURIN	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
FURIN	transfac_pro__M04817	ZBTB33 (directAnnotation).
FURIN	transfac_pro__M12697	ZNF142 (directAnnotation).
FURIN	transfac_pro__M04916	TAF1 (directAnnotation).
FURIN	transfac_pro__M06104	ZNF16 (directAnnotation).
FURIN	swissregulon__hs__HBP1	HBP1 (directAnnotation).
FURIN	metacluster_50.1	BATF; BATF; BATF; BATF; BNC2; FOS; FOSB; FOSL1; FOSL1; IRF4; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMAD2; SMAD3 (directAnnotation). BATF; BATF; BATF; FOS; FOSL1; FOSL2; JDP2; JUN; JUN; JUND (inferredBy_Orthology).
FURIN	transfac_pro__M06071	ZNF814 (directAnnotation).
FURIN	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
FURIN	transfac_pro__M06881	ZNF549 (directAnnotation).
FURIN	metacluster_117.2	GATA3; GATA3; GATA3; GATA5; GATA5; GATA5; GATA5; GATA6; GATA6 (directAnnotation).
FURIN	tfdimers__MD00147	ELF5; TFAP2C (directAnnotation).
FURIN	metacluster_29.2	BCL6; IRF3; IRF3; STAT1; STAT1; STAT1; STAT2; STAT3; STAT3; STAT3; STAT4; STAT4; STAT5A; STAT5A; STAT5A; STAT5A; STAT5B; STAT5B; STAT5B; STAT6 (directAnnotation). STAT3; STAT5A; STAT5A; STAT5A; STAT5A; STAT5A; STAT5B; STAT5B; STAT6; STAT6 (inferredBy_Orthology).
FURIN	transfac_pro__M05605	GATA6 (inferredBy_Orthology).
FURIN	metacluster_172.22	E4F1 (inferredBy_Orthology).
FURIN	transfac_public__M00040	ATF2 (directAnnotation).
FURIN	transfac_pro__M06794	ZNF107 (directAnnotation).
FURIN	cisbp__M01813	CREBZF (inferredBy_Orthology).
FURIN	transfac_pro__M06032	ZNF727 (directAnnotation).
FURIN	tfdimers__MD00423	ARID3A; PAX4 (directAnnotation).
FURIN	transfac_pro__M06834	PEG3 (directAnnotation).
FURIN	kznf__ZNF3_Imbeault2017_RP_RCADE	ZNF3 (directAnnotation).
FURIN	tfdimers__MD00438	E2F1; NKX3-2 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
FURIN	"Capric acid"	DB03600	small molecule

Page: 1

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."