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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FUNDC1

Summary for FUNDC1

Gene information	Gene symbol	FUNDC1
	Ensembl ID	ENSG00000069509
	Entrez ID	139341
	Gene name	FUN14 domain containing 1
	Synonyms	MGC51029
	Gene type	protein_coding
	UniProtAcc	Q8IVP5

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Dataset with differentially expressed gene: FUNDC1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.550331	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.620611	3.62e-40
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.602633	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.331731	2.38e-09
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.811803	0.00e+00

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Expression of FUNDC1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FUNDC1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FUNDC1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FUNDC1	hsa-miR-922	94.4986	NM_173794
FUNDC1	hsa-miR-3692-3p	93.289	NM_173794
FUNDC1	hsa-miR-889-3p	92.5506	NM_173794
FUNDC1	hsa-miR-302b-5p	91.7747	NM_173794
FUNDC1	hsa-miR-302d-5p	91.7747	NM_173794
FUNDC1	hsa-miR-527	89.4917	NM_173794
FUNDC1	hsa-miR-548aw	89.4917	NM_173794
FUNDC1	hsa-miR-518a-5p	89.4917	NM_173794
FUNDC1	hsa-miR-582-5p	87.5257	NM_173794
FUNDC1	hsa-miR-6871-5p	86.1767	NM_173794
FUNDC1	hsa-miR-4799-5p	85.6635	NM_173794
FUNDC1	hsa-miR-6504-3p	81.4625	NM_173794
FUNDC1	hsa-miR-10399-5p	81.4625	NM_173794
FUNDC1	hsa-miR-382-5p	80.8937	NM_173794

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Motifs and transcription factors (TFs) regulating FUNDC1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FUNDC1	hdpi__ETV4	ETV4 (directAnnotation).
FUNDC1	cisbp__M02645	ETS1 (directAnnotation).
FUNDC1	cisbp__M00808	MYPOP (inferredBy_Orthology).
FUNDC1	hdpi__TP73	TP73 (directAnnotation).
FUNDC1	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
FUNDC1	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
FUNDC1	swissregulon__hs__ELK1	ELK1 (directAnnotation).
FUNDC1	metacluster_183.4	ETS1 (inferredBy_Orthology).
FUNDC1	transfac_pro__M04862	NRF1 (directAnnotation).
FUNDC1	hdpi__ELF2	ELF2 (directAnnotation).
FUNDC1	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
FUNDC1	transfac_pro__M04848	TAF1 (directAnnotation).
FUNDC1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
FUNDC1	jaspar__MA0502.2	NFYB (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."